Virchow's triad

Virchow triad


Contributions from cells, plasma, and blood flow (Virchow's Triad) regulate fibrin
formation and therefore, fibrin network structure and stability.
Laser scanning confocal
micrographs show re-calcified, platelet-poor plasma (hemophilia A, normal, and 200%
fibrinogen from left to right, respectively) spikedwith AlexaFluor-488–labeled fibrinogen
(10 μg/120 μL sample) and clotted by TF-bearing monocytes. Abnormally-coarse networks
of thick fibers are associated with an increased risk of bleeding, whereas overly-dense
networks of thin fibers are associated with an increased risk of thrombosis. Characterizing
the specific mechanisms by which cells, plasma and blood flow regulate fibrin structure
and stability is critical for understanding hemostasis and identifying effective targets for
hemostatic and antithrombotic therapies.

Wolberg AS, Aleman MM, Thrombosis Research 2010 Apr;125 Suppl 1:S35-7