The focus of my research lab is on biochemical and cellular mechanisms governing hemostasis and thrombosis, and approved / novel therapeutics for clinical use. Coagulation occurs after cellular proteins are exposed to flowing blood. Exposure of these proteins triggers a series of enzymatic reactions that culminate in the production of thrombin. Thrombin then activates platelets and cleaves the plasma protein, fibrinogen, to fibrin, which polymerizes into a web-like mesh that forms a blood clot. Clot formation is dictated by proteins and cells found in the blood, cells lining the blood vessels, and the flow of blood through the vessels.