May 22-24, 2008
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About
Sponsors
Registration
Abstract Submission
Accommodations
Exhibitor Registration
Browse Exhibitors
Schedule of Events
Directions
Contact Information
Abstracts
38th Mid-Atlantic Macromolecular
Crystallography Meeting
May 22-24, 2008
Sonja Haynes Stone Center
University of North Carolina, Chapel Hill, NC 27599
| Thursday, May 22 | |
| 1:30--3:45 PM | REGISTRATION & CHECK-IN Lobby, Sonja Haynes Stone Center
Posters Setup Exhibitors Setup |
| 3:45--4:00 PM | WELCOME AND OPENING REMARKS
Dr. William Marzluff, Executive Associate Dean for Research UNC School of Medicine Introduction of Keynote SpeakerAuditorium Dr. Edward Collins, UNC-CH |
| 4:00--5:00 PM | KEYNOTE LECTURESonja Haynes Stone Center Auditorium Ian Wilson, D.Phil., D.Sc., FRS. Department of Molecular Biology and Skaggs Institute for Chemical Biology The Scripps Research Institute "High Throughput Structural Biology" |
| 5:15--6:00 PM | RECEPTIONLobby |
| 6:30-- | DINNERCarolina Club |
| Friday, May 23 | |
| 7:30--8:30 AM | CONTINENTAL BREAKFASTHitchcock Multipurpose Room |
| 8:00--8:30 AM | RegistrationLobby, Sonya Haynes Stone Center |
| 8:30--10:30 AM | Auditorium
SESSION I Signal Transduction Chair: John Sondek (UNC Chapel Hill) |
| 8:30--9:00 |
Kevin Slep (UNC Chapel Hill)
Title: Macromolecular mechanisms of microtubule plus end tracking proteins |
| 9:00--9:15 | Chuan-Hsiang Huang (Johns Hopkins University) Title: Effects of Oncogenic PIK3CA Mutations: Insights from the Crystal Structure of a Human PI3Ka complex |
| 9:15--9:45 | Kathryn Ferguson (U. of Pennsylvania) Title: Molecular basis of yeast Vps74 tetramer formation, a requirement for retention of a subset of Golgi enzymes |
| 9:45--10:00 | Young Jun Im (NIH) Title: Integrated structural and functional model of the human ESCRT-II complex |
| 10:00--10:30 | Michael Wiener (University of Virginia) Title: TonB-Dependent Outer Membrane Transport: Novel Results with a Minimal Substrate |
| 10:30--11:00 AM | COFFEE BREAKHitchcock Multipurpose Room |
| 11:00 AM--1:00 PM | Auditorium
SESSION II DNA/RNA biology Chair: Matthew Redinbo (UNC Chapel Hill) |
| 11:00--11:30 | Lorena Beese (Duke University) Title: DNA lesion complexes in replication and repair |
| 11:30-- 11:45 | Christine Dunham (Emory University) Title: Structural Studies of a Large Macromolecular Machine |
| 11:45-- 12:15 |
Traci Hall (NIEHS)
Title: Probing RNA sequence specificity of PUF proteins |
| 12:15--12:30 | Orsolya Barabas (NIH) Title: The Mechanism of Asymmetric DNA Transposition |
| 12:30--1:00 |
Wei Yang (NIH)
Title: Ratchet-and-pull: UvrD helicase unravels the double helix |
| 1:00--2:00 PM | LUNCH BREAKTerrace, Sonja Haynes Stone Center |
| 2:00--4:00 PM | Auditorium
SESSION III Methods Chair: Charlie Carter (UNC Chapel Hill) |
| 2:00--2:25 |
Lawrence DeLucas (Univ. of Alabama - Birmingham)
Title: Novel Protein Expression, Solubilization and Crystallization Technologies |
| 2:25--2:45 | Jane Richardson (Duke University) Title: New PDB Guidelines for Structure Validation |
| 2:45--3:10 |
Maks Chruszcz (Univ. of Virginia)
Title: How Structure Refinement May Affect Interpretation of Biological Function |
| 3:10--3:35 | Charlie Carter (UNC Chapel Hill) Title: Applications of Bayes’s Theorem in Structural Biology |
| 3:35--4:00 |
Marc Allaire (NSLS)
Title: Development of Generic Assays |
| 4:00--4:15 PM | BUSINESS MEETINGAuditorium |
| 4:30--6:30 PM | POSTER SESSION VENDOR SESSION Student Poster Competition Judging Hallway, Hitchcock Multipurpose Room |
| 6:30 PM | Release for dinner on your own |
| Saturday, May 24 | |
| 7:30--8:30 AM | CONTINENTAL BREAKFASTHitchcock Multipurpose Room |
| 8:30--12:00 PM | Auditorium
SESSION IV Therapeutics Chair: Shawn Williams (GlaxoSmithKline) |
| 8:30--9:00 |
Carla Mattos (NC State University)
Title: Probing protein binding sites with multiple solvent crystal structures |
| 9:00--9:30 |
Charles Pemble (Wake Forest University)
Title: Trimming human fatty acid synthase activity |
| 9:30--10:00 |
Kevin Madauss (GlaxoSmithKline)
Title: Identification of a novel ligand- induced binding channel in Glucocorticoid Receptor |
| 10:00--10:30 AM | COFFEE BREAKHitchcock Multipurpose Room |
| 10:30--11:00 |
Priyamvada Acharya (NIH)
Title: Structural characterization of HIV-1 gp120 interaction with CCR5 |
| 11:00--11:30 |
Lisa Shewchuk (GSK)
Title: Tykerb: A Dual EGFR/ErbB2 Inhibitor |
| 11:30--12:00 |
Stephen Soisson (Merck) Title: Identification of a Potent, Synthetic FXR Agonist with an Unexpected Mode of Binding and Activation |
| 12:00 PM | CLOSING REMARKS
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