Luis A. Diaz, M.D., Professor and Chair
Education/Degrees
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Universidad Nacional de Trujillo (Trujillo, Peru), Pre-Medicine
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School of Medicine of the Universidad Nacional de Trujillo (Trujillo,
Peru)
M.D.
Postgraduate
Training
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Internship:Department of Medicine, Ellis Hospital, Schenectady, N.Y.
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Dermatology Residency: SUNY of Buffalo Affiliated Hospitals,
Buffalo,
N.Y.
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Fellowship: Post doctoral fellow in Immunology, Mayo
Graduate
School of Medicine, Rochester, MN
Academic Career
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University of Michigan (Assist and Assoc Prof, 1976-1982)
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Johns Hopkins University (Assoc Prof and Prof 1982-1988)
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Medical College of Wisconsin (Prof & Chairman, Dermatology Dept
1989-1999)
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University of North Carolina at Chapel Hill (Prof & Chairman,
2000-to
date)
Research Interests
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Human autoimmunity, autoimmune blistering diseases.Studies focus on
defining
the immunopathological mechanisms involved in three human autoimmune
diseases:
Pemphigus Vulgaris, Pemphigus Foliaceus and Bullous Pemphigoid.
Publications
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The following major scientific contributions are credited to Dr. Diaz’s
research team:
1. Development of the first animal model of
Pemphigus
Vulgaris by passive transfer of human anti-epidermal
autoantibodies.
N. Engl. J. Med. 306:1189?1196, 1982.
2. Development of the first animal model of
Pemphigus Foliaceus by passive transfer of human anti-epidermal
autoantibodies.
J. Invest. Dermatol. 85:538?541, 1985.
3. Development of the first animal model of
Bullous Pemphigoid by passive transfer of human anti-epidermal
autoantibodies in
the rabbit cornea. J. Clin. Invest. 68:1097?1101, 1981.
4. Demonstration that Bullous Pemphigoid
autoantibodies
recognize epidermal basal cell hemidesmosomes. J. Invest.
Dermatol. 84:47?53,
1985.
5. Immunochemical characterization and
molecular
cloning of the human hemidesmosome BP180 antigen. J. Immunol.
36:1231?1235, 1986
and J. Clin. Invest. 86:1088?1094, 1990.
6. Development of the first animal model of
Bullous Pemphigoid in the neonatal mouse by transfer of
anti-hemidesmosomal
BP180 antigen antibodies. J. Clin. Invest, 92:2480-2488, 1993.
7. Cloning of desmoglein 3-specific T cells
from Pemphigus Vulgaris peripheral blood lymphocytes. Clin.
Invest,
99:31-40, 1997.
8. Cloning of desmoglein 1-specific T cells
from peripheral blood lymphocytes of endemic pemphigus foliaceus (Fogo
Selvagem). Clin.
Invest. 105:207-213, 2000.
9. The prevalence of antibodies against
desmoglein
1 in endemic pemphigus foliaceus in Brazil. N. Engl J Med
343:23-30, 2000
Academic
Highlights
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William Montagna Lecturer, Society for Investigative Dermatology, 1991.
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Marion Sulzberger Award: Teacher of the Year, American Academy of
Dermatology,
1994.
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Simon Bolivar Academic Achievement Award from the Universidad Nacional
de Trujillo, 1999.
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President, Society for Investigative Dermatology, 2000-2001.
Memberships
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American Academy of Dermatology
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Society for Investigative Dermatology
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American Dermatological Association
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American Society of Clinical Investigation
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Association of American Physicians
- Institute of Medicine