Education/Degrees:
1959
1963
2002 University of Rochester School of Medicine and Dentistry, MPH, (clinical investigation)
Professional
Training and Experience:
1963-64 Medical Intern,
1964-65
Assistant Resident in medicine,
1965-67 Research Associate, National Institutes of Health, National Institute of Child Health and Human Development, Laboratory of Biomedical Sciences, Bethesda, Maryland
1967-69 Research
Fellow in Dermatology,
1969-70
Postdoctoral Fellow, Graduate Department of
Biochemistry,
Faculty
Appointments:
2002- Professor of Dermatology, University of North Carolina School of Medicine, Chapel Hill, North Carolina
2000- Dean
Emeritus,
1996-2000 Dean,
1987-1996 James H. Sterner Professor of Dermatology and Professor and Chairman, Department of Dermatology, University of Rochester School of Medicine and Dentistry
1981-87
James H. Sterner Professor of
Dermatology and Chief, Dermatology Unit (Medicine),
1985-87 Acting Chairman, Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY
1978-81 Professor
of Medicine,
1973-78
Associate Professor of Medicine,
1971-73
Assistant Dermatologist,
1970-73
Assistant Professor of Dermatology,
1970-71 Assistant in Dermatology,
1978-79 Fellow, Macy Foundation,
1994
Sabbatical, Imperial Cancer Research
Fund,
Honors:
Editor, Journal of Investigative Dermatology,
2002-2007
Associate Editor, Fitzpatrick Dermatology and
General Medicine, 5th Edition and 6th Edition, 2003
Rothman Gold Medal Society, Investigative
Dermatology.
Past-President Association of Professors of
Dermatology, Society for Investigative Dermatology, American Dermatology
Association
Research
Interests:
Genetic defects of epidermis
Development of a dermatology lexicon
Selected
Publications:
1. Goldsmith
LA,
2. Goldsmith LA, Thorpe J, Roe CR. Hepatic enzymes of tyrosine metabolism in tyrosinemia II. J Invest Dermatol. 73:530-532, 1979
3. Goldsmith LA, Thorpe JM, Marsh RF: Tyrosine aminotransferase deficiency in mink (Mustela vision[sic]): a model for human tyrosinemia II. Biochem Genet. 19:687, 1981
4. Levy SB, Goldsmith LA: The peeling skin syndrome. J Am Acad Dermatol. 7:606, 1982
5. Lesiewicz J, Goldsmith LA: Antizyme release is an early event in ornithine decarboxylase induction by hair plucking. J Invest Dermatol. 80:97, 1983
6. Lane AT, Helm KF, Goldsmith LA: Identification of bullous pemphigoid, pemphigus, laminin, and anchoring fibril antigens in human fetal skin. J Invest Dermatol. 84:27, 1985
7. Lane AT, Negi M, Goldsmith LA: Human periderm: a monoclonal antibody marker. Curr Probl Dermatol. 16:83, 1987
8. Goldsmith LA: Sulfhydryl oxidase from rat skin. Methods Enzymol. 143:510, 1987
9. Goldsmith LA: My organ is bigger than your organ. Arch Dermatol. 126:301, 1990
10. Zheng ZS, Goldsmith LA: Modulation of epidermal growth factor receptors by retinoic acid in ME180 cells. Cancer Res. 50:1201, 1990
11. Goldsmith LA: Physiology,
Biochemistry, and Molecular Biology of the Skin. 2nd ed,
12. Goldsmith LA, DeYoung LM, Falciano V et.al: Inhibition of human epidermal transglutaminases in vitro and in vivo by tyrosinamidomethyl dihydrohaloisoxazoles. J Invest Dermatol. 97:156, 1991
13. Fairley JA, Scott GA, Jensen KD et.al: Characterization of keratocalmin, a calmodulin-binding protein from human epidermis. J Clin Invest. 88:315, 1991
14. Foresman PL, Goldsmith LA, Ginn L et.al: Hemorrhagic Darier's disease. ArchDermatol. 129:511, 1993
15. Ikeda S: Localization of the gene for Darier's disease to a 5cM interval on chromosome 12q. J Invest Dermatol. 103:478, 1994
16. Schroeder WT, Stewart-Galetka S, Mandavilli S et.al: Cloning and characterization of a novel epidermal cell surface antigen (ESA). J Biol Chem. 269:19983, 1994
17. Zalka AD, Byarlay JA, Goldsmith LA: Alopecia a deux: simultaneous occurrence of alopecia in a husband and wife. Arch Dermatol. 130:390, 1994
18. Zareba G, Cernichiari E, Goldsmith LA et.al: Biological monitoring of iodine, a water disinfectant for long-term space missions. Environ Health Perspect. 103:1032, 1995
19. Worobec S, Byarlay JA, Goldsmith LA: Darier's Disease Association with Coproporphyrinuria. J Invest Dermatol. 104:637, 1995
20. Lu B, Scott G, Goldsmith LA: A model for keratinocyte gene therapy: preclinical and therapeutic considerations. Proc Assoc Am Physicians. 108:165, 1996
21. Ryan AS, Goldsmith LA: Nutrition and the skin. Clin Dermatol. 14:389, 1996
22. Goldsmith LA: Skin effects of air pollution. Otolaryngology - Head & Neck Surgery. 114:217, 1996
23. Goldsmith LA: Genetic skin diseases with altered aging. Arch Dermatol. 133:1293, 1997
24. Lu B, Federoff HJ, Wang Y et.al: Topical application of viral vectors for epidermal gene transfer. J Invest Dermatol. 108:803, 1997
25. O'Malley MP, Haake A, Goldsmith L et.al: Localized Darier disease. Implications for genetic studies. Arch Dermatol. 133:1134, 1997
26. Pan HJ, Wilding G, Uno H et.al: Evaluation of RU58841 as an anti-androgen in prostate PC3 cells and a topical anti-alopecia agent in the bald scalp of stumptailed macaques. Endocrine. 9:39, 1998
27. Inui,S,
Lee,YF,
28. Gogstetter DS Goldsmith LA: Treatment of cutaneous sarcoidosis using phonophoresis. J Am Acad Dermatol. 40:767, 1999
29. Goldsmith LA:
30. Nieves DS, Phipps RP, Pollock SJ, Ochs et al: Dermatologic and immunologic findings in the immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome. Arch Dermatol. 140(4): 466-72, 2004
31. Papier, A, Chalmers, RJ, Byrnes, JA, Goldsmith, LA; Dermatology Lexicon Project: Framework for improved communication: the Dermatology Lexicon Project. J Am Acad Dermatol. 50(4):630-4, 2004
32. DeVries, DT, Papier, A, Byrnes, J, Goldsmith, LA. Medical and dermatology dictionaries: an examination of unstructured definitions and a proposal for the future. J Am Acad Dermatol. 50(1):144-7, 2004