The Patterson laboratory uses molecular, genetic, and physiologic approaches to ask
questions regarding events that underlie the processes of angiogenesis, vascular
development, cardiac failure, and atherosclerosis. Our laboratory employs a wide range
of methods, including standard molecular techniques, gene discovery applications,
genetically modified animals, and microphysiologic techniques. We have a particular
interest in understanding the genes that regulate angiogenesis, identifying stress-responsive
genes that modify cardiac function, and characterizing oxidative pathways in atherogenesis.
Recent Publications:
Qian, S-B., McDonough, H., Boellman, F., Cyr, D.M., and Patterson, C. (2006) CHIP-mediated stress recovery by hierarchical substrate-dependent autoregulation of Hsp70. Nature [in press].
Dai, Q., Qian, S-B., Li, H-H., McDonough, H., Borchers, C., Huang, D., Takayama, S., Younger, J.M., Ren, H.Y., Cyr, D.M., and Patterson, C. (2005) Regulation of the cytoplasmic quality control protein degradation pathway by BAG2. J Biol Chem 280: 38673-38681. Abstract
Kedar, V., McDonough, H., Arya, R., Li, H-H., Willis, M., Rockman, H.A., and Patterson, C. (2004) Muscle-specific Ring Finger 1 is a bona fide ubiquitin ligase that degrades cardiac troponin I. Proc Natl Acad Sci USA 101(52): 18135-40. Abstract
Li, H-H., Kedar, V., Zhang, C., McDonough, H., Arya, R., Wang, D-Z., and Patterson, C. (2004) Atrogin-1 inhibits calcineurin-dependent cardiac hypertrophy by participating in an SCF ubiquitin ligase complex. J Clin Invest 114(8): 1058-1071. Abstract
Arya, R., Kedar, V., Hwang, J.R., McDonough, H., Li, H-H., Taylor, J., and Patterson, C. (2004) Muscle ring finger protein-1 inhibits PKCε activation and prevents
cardiomyocyte hypertrophy.
J Cell Biol167(6): 1147-59. Abstract
