BIOGRAPHICAL SKETCH

4/05

 

NAME

James E. Faber

 

POSITION TITLE

Professor

 

 

EDUCATION/TRAINING  (Begin with baccalaureate or other initial professional education, such as nursing, and include postdoctoral training.)

INSTITUTION AND LOCATION

DEGREE

(if applicable)

YEAR(s)

FIELD OF STUDY

University of Missouri-Columbia

B.S.

1970-1974

Biology

University of Missouri-Columbia

Ph.D.

1976-1981

Physiology

University of Iowa

Postdoctoral

1981-1983

Pharmacology

 

 

 

 

 

 

 

 

A.  Positions and Honors:

1983-1989:              Assistant Professor, Dept. Physiology, University of North Carolina at Chapel Hill

1989-1994:              Associate Professor, Dept. Physiology, University of North Carolina at Chapel Hill

1994-present:          Professor, Dept. Physiology, University of North Carolina at Chapel Hill

Selected Honors and Awards:

NIH-Research Career Development Award, 1989-94

Hyman Battle Distinguished Excellence in Medical Teaching Award, 1998, 2002

Teacher of the Year, 1996, 2000

Medical School Best First-Year Course Award, 1997, 2000 (course director)

North Carolina Governor’s Teaching Excellence Award, 1999, 2001

Kaiser-Permanente Excellence Professor, 2000

UNC Distinguished Teaching Award for Post-Baccalaureate Education, 2004

Faculty of the Year Award, UNC Student National Medical Association, 2004 

 

Study Section, Editorial, and Advisory Service:

NIH-NHLBI Program Project Site Visit Team 1985; NHLBI study sections:  Experimental CV Sciences 1989-91 (ad hoc) 1993-96 (regular member);

Cardiovascular B 2001 (ad hoc); Vascular Cell and Molecular Biology 2004 (ad hoc)

Associate Editor,           American Journal of Physiology-Heart Circ. Physiol., 1993-1999

Editorial Boards:            American Journal of Physiology-HCP, 1991-93

                                    Journal of Vascular Research, 1991-1999

                                    Journal of Pharmacology and Experimental Therapeutics, 1999,2000

American Heart Association abstract reviewer for fall meeting, 2002-present; oral session moderator, 2004

Am Microcirculation Soc Committees:  Awards 87-89; Executive 90-93, 98; Program 93-95; Liaison 95-98; Council 98-01

American Physiological Society Committees:  CV Section Nominating 92-96; CV Section Steering 93-96; Daggs Award Committee 99-2001 (Chair 2001); CV Section Awards Committee 00-present

 

B.  Peer-Reviewed Publications (last 3 years plus selected, in chronological order):

Ohyanagi M, Nishigaki K, Faber JE (1991) Differential activation of alpha1 and alpha2 adrenoceptors on microvascular smooth muscle during sympathetic nerve stimulation.  Circulation Res 68:232-244

McGillivray-Anderson KM, Faber JE (1991) Effect of reduced flow on alpha1 and alpha2 adrenoceptor constriction of skeletal muscle microvessels.  Circulation Res 69:165-173

Anderson KM, Faber JE (1991) Differential sensitivity of arteriolar a1- and a2-adrenoceptor constriction to metabolic inhibition during skeletal muscle contraction.  Circulation Res 69:174-184

Meininger GA, Faber JE (1991) Adrenergic tone selectively augments myogenic contraction in skeletal muscle microcirculation.  Am J Physiol-Heart Circ Physiol 260:H1424-1432

Muldowney SM, Faber JE (1991) Venular but not arteriolar smooth muscle reactivity is preserved during reduced tissue perfusion.  Circulation Res 69:1215-1225

Ohyanagi M, Nishigaki K, Faber JE (1992) Interaction between microvascular alpha1-and alpha2-adrenoceptors and endothelial-derived relaxant factor.  Circulation Res 71:188-199

Ping P and Faber JE (1993) Characterization of alpha-adrenergic gene expression in arterial and venous smooth muscle.  Am J Physiol-Heart Circ Physiol 265 H:1501-1509

Tateishi J, Faber JE. (1995) ATP-sensitive potassium channels mediate a2D-adrenoceptor contraction of arteriolar smooth muscle and reversal of contraction by hypoxia.  Circulation Res 76: 53-63

Chen L-Q, Xin X, Eckhart AE, Yang N, Faber JE.  (1995) Regulation of vascular smooth muscle growth by a1-adreno-ceptor subtypes in vitro and in vivo.  J Biol Chem 270 (52):30980-30988

Bylund DB, Regan JW, Faber JE, Heible JP, Triggle CR, Ruffolo RRJr (1995) Vascular alpha-adrenoceptors: From the gene to the human.  Can J Physiol Pharmacol 73 (5):533-543

Leech CJ, Faber JE (1996) Different alpha-adrenoceptor subtypes mediate constriction of arterioles and venules.  Am J Physiol-Heart Circ Physiol 279:H710-H722

Leech  CJ, Faber JE  (1996) Differential sensitivity of venule and arteriole a-adrenergic receptor constriction to inhibition by hypoxia:  Role of receptor subtype and coupling heterogeneity.  Circulation Res 78:1064-1074

Eckhart AE, Zhu Z, Arendshorst WJ,  Faber JE.  (1996) Oxygen modulates alpha1B-adrenoceptor gene expression by arterial but not venous vascular smooth muscle. Am J Physiol-Heart Circ Physiol 271:H1599-H1608

Clements ML, Banes AJ, Faber JE (1997) Effect of mechanical loading on vascular a1D- and a1B-adrenergic receptor expression.  Hypertension, 29:1156-1164

Yang N, Eckhart AE, Xin X, Faber JE (1997) CRE-like response element regulates expression of rat a2D-adrenergic receptor gene in vascular smooth muscle. Am J Physiol-Heart Circ Physiol, 273:H85-H95

Xin X, Yang N, Eckhart AD, Faber JE. (1997) a1D-Adrenergic receptors and mitogen-activated protein kinase increase protein synthesis by arterial smooth muscle.  Mol Pharm, 51:764-775

Eckhart AD, Yang N, Xin X, Faber JE (1997) Characterization of the a1B-adrenergic receptor gene promoter region and hypoxia regulatory elements in vascular smooth muscle.  Proc Nat Acad Sci USA, 94:9487-9492

Yang N, Wang S, Faber JE (1999) RNase protection assays for quantitation of gene expression in vascular tissue.  In: Methods in Molecular Medicine, Vascular Disease: Molecular Biology and Gene Therapy Protocols.  Edited by AH Baker, Humana Press Inc, Totowa, NJ, Chapter 18

Xin X, Yang N, Faber JE (1999) Platelet-derived growth factor inhibits a1D-adrenergic receptor expression in vascular smooth muscle cells in vitro and in vivo.  Mol Pharm 56:1143-1151

Xin X, Yang N, Faber JE (1999) Platelet-derived growth factor inhibits rat a1D-adrenergic receptor gene expression in vascular smooth muscle cells by inducing AP2-like protein binding to the a1D proximal promotor region.  Mol Pharm 56:1152-1161

Salmonsson M, Oker M, Kim S, Zhang H, Faber JE, Arendshorst WJ. (2001) a1-Adrenoceptor subtypes on rat afferent arterioles assessed by radioligand binding and RT-PCR.  Am J Physiol-Renal Electrolyte Physiol 281:F172-178

Faber JE, Yang N, Xin X (2001) Expression of a-adrenergic receptor subtypes by smooth muscle cells and adventitial fibroblasts in intact rat aorta and in cell culture.  J Pharmacol Exp Ther 298:441-452

Zhang H, Faber JE (2001) Norepinephrine augments injury-induced growth of the arterial intima-media and adventitia: 

Mediation by different a1-adrenoceptor subtypes.  Circulation Res  89:815-822

Zhang H, Facemire C, Banes AJ, Faber JE. (2002) Different a-adrenoceptors mediate migration of vascular muscle cells and adventitial fibroblasts in vitro.  Am J Physiol-Heart Circ Physiol 282:H2364-H2370

Erami C, Zhang H, French DM, Ho JG, Faber JE. (2002)  a1-Adrenoceptor stimulation directly induces growth of the vascular wall in vivo.  Am J Physiol-Heart Circ Physiol 283:H1577-H1587.

Teeters JC, Erami C, Zhang H, Faber JE (2003) Systemic a1A-adrenoceptor antagonist inhibits neointimal growth after balloon injury of rat carotid artery.  Am J Physiol-Heart Circ Physiol 284:H385-392

Tsuzaki M, Bynum D, Almekinders L, Yang X, Faber JE, Banes AJ.  (2003) ATP modulates load-inducible IL-1b, COX 2 and MMP-3 gene expression in human tendon cells.  J Cell Biochem  9999:1-8

Bleeke T, Zhang H, Madamanchi H, Patterson C, Faber JE. (2004) Catecholamine-induced vascular wall growth is dependent on generation of reactive oxygen species.  Circulation Res 94:37-45

Wall ME, Faber JE, Yang X, Tsuzaki, Banes AJ (2004) Norepinephrine-induced calcium signaling and expression of adrenoceptors in avian tendon cells. Am J Physiol Cell Physiol 287(4):C912-928.

Zhang H, Thomas SA, Cotecchia S, Tanoue A, Tsujimoto G and Faber JE (2004) Gene deletion of dopamine b-hydroxylase and a1-adrenoceptors demonstrates involvement of catecholamines in vascular remodeling.  Am J Physiol Heart Circ Physiol 287:H2106-H2114

Zhang H, Chalothorn D, Jackson L, Lee DC, Faber JE (2004) Transactivation of epidermal growth factor receptor mediates catecholamine-induced growth of vascular smooth muscle. Circulation Res 95:989-997

Tsuzaki M, Bynum D, Almekinders L, Faber JE, Banes AJ.  (2005) Mechanical loading stimulates ecto-ATPase activity in human tendon cells.  J Cell Biochem (in press – see journal website for e-version).

Erami C, Zhang H, Tanoue A, Tsujimoto G, Thomas SA, Faber JE.  (2005) Adrenergic catecholamine trophic activity contributes to flow-mediated arterial remodeling.  Am J Physiol Heart Circ Physiol (in press - see journal website for e-version)

Chalothorn D, Zhang H, Thomas SA, Faber JE.  (2005) Catecholamines augment collateral vessel growth and angiogenesis in   hind limb ischemia.  Am J Physiol Heart Circ Physiol (in press - see journal website for e-version)

Chalothorn D, Moore SM, Zhang H, Clayton JA, Sunnarborg SW, Lee DC, Faber JE.  Heparin-binding epidermal growth factor-like growth factor, collateral vessel development and angiogenesis in skeletal muscle ischemia.  Arterioscler Thromb Vasc Biol (in review)

Qi J, Otey C, Faber JE, Banes AJ. ATP modulation of osteoblast-populated collagen gel contraction. (in review).

Wall ME, Yang X, Faber JE, Boitano S, Banes AJ.  Cyclic strain and norepinephrine modulate intercellular communication in tenocytes. Am J Physiol Cell Physiol (in review).   

 

C.  Selected Abstracts Not Yet Published in Full:

Faber JE and Yang N (1999) Angioplasty injury reduces a-adrenoceptor subtype expression in neointima, media and adventitia.  FASEB J 13:A515 

Faber JE, Zhang H, Thomas SA, Cotecchia S, Tsujimoto G and Szymeczek-Seay  CL (2002) a1-Adrenoceptor-mediated trophic action in hypoxic pulmonary hypertension:  Evidence from gene knockouts for dopamine beta-hydroxylase, a1B- and a1D-AR.  Am J Resp Crit Care Med, 165(8):A749 

Faber JE, Zhang H, Szymeczek-Seay C, and Salvi S (2001) Trophic effect of norepinephrine on pulmonary arteries is augmented by hypoxic pulmonary hypertension. Am J Resp Crit Care Med 163(5):A398 

 

 

D.  Patents:  JE Faber and The University of North Carolina.  U.S. Provisional 60/303,134:  Blockade of Specific Alpha 1-Adrenergic Receptors as a Therapy to Lessen Excessive Vascular Wall Growth.  July, 2001.  

 

 

E.  Genbank Submissions:  Xin X, Yang N, Faber JE (1998) Rattus norvegicus alpha-1D adrenergic receptor gene, genomic sequence, 5' region. Genbank BankIt201954  AF071014

 

 

F.  Grants, Trainee Fellowships, Other support: 

Current Support:

1-0   “-Adrenoceptors in vascular wall growth and remodeling", NIH-NHLBI, R01; PI.

2003-2007    “Tendon cell interactions & responses to stress in vitro", NIH, R01, Co-I (A Banes PI, BME, UNC).

1-0                               “Signaling pathways activating adhesion in sickle cells”, NIH, R01, Co-I (L Parise PI, Pharm, UNC).

1-0                               “Mechanisms of vascular wall aging and disease”, NIH, P01, Co-I (D Clemmons, PI, Med, UNC).

2005-2008    “Mechanisms of collateral arteriogenesis in ischemia”, NIH-NHLBI, 1 F32 HL080847 (Dan Chalothorn).  

1-0                                 Predoctoral MD-PhD fellowship to Jason Clayton (NIH Vascular Biology Training Grant).

 

Pending:

 

1-0                               “Tendon cells: Interactions and responses to stress in vitro" NIH, RO1, Co-I (A Banes, PI, BME, UNC). 

           

Training Grant Membership (no support):

2002-2006     Vascular Biology Training Grant, NIH-NHLBI (N Maeda, PI, Pathology, UNC). 

1-0                                 Cell & Molecular Biology Training Grant, NIH (W Marzluff, PI, Biochemistry, UNC).

2003-2008     MD-PhD Training Grant, NIH (WC Patterson, PI, Medicine, UNC).

2003-2008     NHLBI Short-term training for Minority Student Program (WC Patterson, Medicine, UNC).