Eva Anton, PhD
Associate Professor

Education:

BS, St. Olaf College 1986
PhD, Duke University 1994

Molecular Analysis of Neuronal Migration and Layer Formation in Cerebral Cortex

Laminar organization of neurons in cerebral cortex is critical for normal brain function. Two distinct cellular events guarantee the emergence of laminar organization-- coordinated sequence of neuronal migration, and generation of radial glial cells that supports neurogenesis and neuronal migration. Our goal is to understand the cellular and molecular mechanisms underlying neuronal migration and layer formation in the mammalian cerebral cortex. Towards this goal, we are studying the following three related questions:

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1. What are the signals that regulate the establishment, development and differentiation of radial glial cells, a key substrate for neuronal migration in cerebral cortex?

2. What are the signals for neuronal migration that determine how neurons reach their appropriate positions in the developing cerebral cortex?

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3. What are the specific cell-cell adhesion related mechanisms that determine how neurons migrate and coalesce into distinct layers in the developing cerebral cortex?

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Selected Publications

Anton ES , Ghashghaei HT, Weber JL, McCann C, Fischer TM, Cheung ID, Gassmann M, Messing A, Klein R, Schwab MH, Lloyd KCK, Lai C. (2004) Receptor tyrosine kinase ErbB4 modulates neuroblast migration and placement in the adult forebrain. Nat Neurosci. 7:1319 - 1328.

Schmid RS, Shelton S, Stanco A, Yokota Y, Kreidberg JA, Anton ES. (2004) a3ß1 integrin modulates neuronal migration and placement during early stages of cerebral cortical development. Development 31(24):6023-6031.

Yokota Y, Anton ES. (2004) Calcium waves rule and divide radial glia. Neuron 43(5):599-601.

Demyanenko GP, Schachner M, Anton E, Schmid R, Feng G, Sanes J, Maness PF. (2004) Close homolog of L1 (CHL1) modulates area-specific neuronal migration and dendrite orientation in the cerebral cortex. Neuron 44(3):423-37.

Gongidi V, Ring C, Moody M, Brekken R, Sage EH, Rakic P, Anton ES. (2004) Sparc-like 1 is a radial glia-associated terminator of neuronal migration in cerebral cortex. Neuron. 41: 57-69.

Polleux F, and Anton ES. (2004) Neuronal migration in the developing brain. In Developmental Neurobiology. (Eds. Rao, M. and Jacobsen, M.), Plenum Press, NY.

Schmid RS, McGrath B, Berechid BE, Boyles B, Marchionni M, Sestan N, Anton ES. (2003) Neuregulin 1-erbB2 signaling is required for the establishment of radial glia and their transformation into astrocytes in cerebral cortex. Proc Natl Acad Sci U S A. 100(7):4251-6

Schmid RS, Anton ES. (2003) Role of integrins in the development of the cerebral cortex. Cereb Cortex. 13(3):219-24.

McGrath B, McCann C, Eisenhuth S, Anton ES. (2001) Molecular mechanisms of interactions between radial glia and neurons. Prog Brain Res 132:197-202.

Dulabon L, Olson EC, Taglienti MG, Eisenhuth S, McGrath B, Walsh CA, Kreidberg JA, Anton ES. (2000) Reelin binds alpha3beta1 integrin and inhibits neuronal migration. Neuron 27(1):33-44.

Anton ES, Kreidberg JA, Rakic P. (1999) Distinct functions of alpha3 and alpha(v) integrin receptors in neuronal migration and laminar organization of the cerebral cortex. Neuron 22(2):277-89.

Anton ES, Marchionni MA, Lee KF, Rakic P. (1997) Role of GGF/neuregulin signaling in interactions between migrating neurons and radial glia in the developing cerebral cortex. Development 124(18):3501-10.

Mahanthappa NK, Anton ES, Matthew WD. (1996) Glial growth factor 2, a soluble neuregulin, directly increases Schwann cell motility and indirectly promotes neurite outgrowth. J Neurosci. 16(15):4673-83.

Anton ES, Cameron RS, Rakic P. (1996) Role of neuron-glial junctional domain proteins in the maintenance and termination of neuronal migration across the embryonic cerebral wall. J Neurosci. 16(7):2283-93.

Marchionni MA, Kirk CJ, Isaacs IJ, Hoban CJ, Mahanthappa NK, Anton, ES, Chen C, Wason F, Lawson D, Hamers FP, Canoll PD, Reynolds R, Cannella B, Meun D, Holt WF, Matthew WD, Chen LE, Gispen WH, Raine CS, Salzer JL, Gwynne DI. (1996) Neuregulins as potential drugs for neurological disorders. Cold Spring Harb Symp Quant Biol. 61:459-72. Review.