BIOGRAPHICAL SKETCH

BIOGRAPHICAL SKETCH Provide the following information for the key personnel in the order listed for Form Page 2. Follow the sample format on preceding page for each person. DO NOT EXCEED FOUR PAGES.

NAME Kathleen MI Caron, Ph.D.		POSITION TITLE Assistant Professor
EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, and include postdoctoral training.)
INSTITUTION AND LOCATION	DEGREE (if applicable)		YEAR(s)	FIELD OF STUDY
Emory University, Atlanta, GA	B.S.		1992	Biology
Emory University, Atlanta, GA	B.A.		1992	Philosophy
Duke University, Durham, NC	Ph.D.		1997	Cell Biology
Univ. of North Carolina-CH, Chapel Hill, NC	Postdoctoral		1997-2003	Genetics of Hypertension

A. Positions and Honors

Professional Experience

Howard Hughes Summer Research Stipend, Duke University (PI Lefkowitz) 1990, 1991

Student, Applied Physiology, Finch Univ. of Health Sciences, Chicago 1992-1993

Graduate Student, Cell Biology, Duke University (Mentor KL Parker) 1993-1997

Postdoctoral Fellow, Pathology, UNC-Chapel Hill (Mentor O Smithies) 1997-2003

Awards & Honors

Lecturer at WHO Symposium on Molecular Approaches to Reproductive Health- Oulu, Finland, 1996

Keynote Speaker at Serono Symposia on Ovarian Cell Growth, Apoptosis and Cancer- Ontario, 1996

Guest Lecturer at Gordon Research Conference on Reproductive Tract Biology, 1998

Elected as Department of Pathology & Laboratory Medicine Faculty/Post-doctoral Liaison, 1998

NIH Individual National Research Service Award, Postdoctoral Training Fellowship, 1999

American Heart Association Postdoctoral Fellowship- Awarded but declined, 2000

Poster Presenter at Gordon Research Conference on Reproductive Tract Biology, 2000

Recipient of Burroughs Wellcome Fund Career Award in the Biomedical Sciences, 2001

Invited Speaker, COE International Symposium, Endogenous Vasodilators- Osaka, Japan 2001

Guest Lecturer at Gordon Research Conference on Reproductive Tract Biology, 2002

Invited Speaker, Triangle Telemetry User Group; "Telemetry in Mouse Models"- Durham, NC, 2002

B. Selected Peer-Reviewed Publications

1. Clark, B.J., Soo, S.-C., Caron, K.M., Ikeda, Y., Parker, K.L., and Stocco, D.M. (1995) Hormonal and developmental regulation of the steroidogenic acute regulatory protein. Molecular Endocrinology 9:1346-1355.

2. Caron, K.M., Ikeda, Y., Soo, S.-C., Stocco, D.M., Parker, K.L., and Clark, B.J. (1997) Characterization of the promoter region of the mouse gene encoding the steroidogenic acute regulatory protein. Molecular Endocrinology 11:138-147.

3. Caron, K.M., Clark, B.J., Ikeda, Y., and Parker, K.L. (1997) Steroidogenic factor 1 acts at all levels of the reproductive axis. Steroids 62:53-56.

4. Caron, K.M., Soo, S.-C., Wetsel, W.C., Stocco, D.M., Clark, B.J., and Parker, K.L. (1997) Targeted disruption of the mouse gene encoding steroidogenic acute regulatory protein provides insights into congenital lipoid adrenal hyperplasia. Proc. Natl. Acad. Sci. USA. 94(21): 11540-5.

5. Wong, M., Ikeda, Y., Luo, X., Caron, K.M., Weber, T.J., Swain, A., Schimmer, B.P., and Parker, K.L. (1997) Steroidogenic factor 1 plays multiple roles in endocrine development and function. Recent Progress in Hormone Research 52:167-84.

6. Caron, K.M., Soo, S.-C., and Parker, K.L. (1998) Targeted disruption of StAR provides novel insights into congenital adrenal hyperplasia. Endocrine Research 24(3-4):827-34.

7. Caron K.M., Ikeda Y., Luo X., and Parker K.L. (1998) Steroidogenic factor 1 plays key roles in adrenal and gonadal development and in endocrine function. In: Contemporary Endocrinology: Neurosteroids: a new regulatory function in the nervous system, edited by E.-E Baulieu, P. Robel, and M. Schumacher, Humana Press, Inc. Totowa NJ.

8. Dellovade T.L., Young M., Ross E.P., Henderson R., Caron K.M., Parker K.L., and Tobet S.A. (2000) Disruption of the gene encoding SF-1 alters the distribution of hypothalamic neuronal phenotypes. J. Comp. Neurol. 423(4):579-589.

9. Hasegawa T., Zhao L., Caron, K.M. and Parker K.L. (2000) Developmental roles of the steroidogenic acute regulatory protein (StAR) knockout mice. Mol. Endocrinol. 14(9):1462-1472.

10. Caron KM and Smithies O. Extreme hydrops fetalis and cardiovascular abnormalities in mice lacking a functional Adrenomedullin gene. 2001 Proc Natl Acad Sci USA 98(2):615-619.

11. Rapacciuolo A, Esposito G, Caron KM, Mao L, Thomas SA and Rockman HA. Important role of endogenous norepinephrine and epinephrine in the development of in vivo pressure-overload cardiac hypertrophy. 2001 J Am College of Cardiology 38(3):876-882.

12. Caron KM, James L, Kim H-S, Morham S, Lopez ML, Gomez A, and Reudelhuber T, and Smithies O. A genetically clamped renin transgene for the induction of hypertension. 2002 Proc Natl Acad Sci USA 99(12):8248-8252.

13. Caron KM and Smithies O. Multiple roles of adrenomedullin revealed by animal models. 2002 Micros Resch Tech 57:55-59.

C. Research Support

Ongoing

Career Award in Biomedical Sciences, Caron (PI) 9/1/01 - 08/31/07

The Burroughs Wellcome Fund

The goal of this career award is to elucidate the reproductive and cardiovascular role of adrenomedullin system by generating and characterizing genetically modified mouse models of adrenomedullin, its receptor and associated signaling proteins.

Role: PI

Completed

1 F32 HL10344-01, Caron (PI); (Oliver Smithies- Mentor) 6/1/00 - 8/31/01

NIH/NIHLB Fellowship

The goal of this post-doctoral fellowship was to generate "gene titration" adrenomedullin mouse models and characterize their cardiovascular phenotype.

Role: PI