BIOGRAPHICAL SKETCH Provide the following information for the key personnel in the order listed for Form Page 2. Follow the sample format on next page for each person. DO NOT EXCEED FOUR PAGES.
NAME Pauline Kay Lund		POSITION TITLE Professor
EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, and include postdoctoral training.)
INSTITUTION AND LOCATION	DEGREE (if applicable)		YEAR(s)	FIELD OF STUDY
University of Newcastle upon Tyne	B. Sc. Hons.		1975	Physiology
University of Newcastle upon Tyne	PhD		1979	G.I. Endocrinology
Massachusetts General Hospital and	Postdoctoral		1979-82	Recomb.DNA Glucagon
Harvard Medical School (joint)	Res. Fellow			Biosynthesis

A. Positions and Honors.

Professional Experience

1982-1988 Assistant Professor in Physiology (tenure track), University of North Carolina

1988-1993 Associate Professor in Physiology (tenured), University of North Carolina

1995-1996 Senior research fellow, Ludwig Institute for Cancer Research

1995-1998 Professor of Distinguished Teaching (Named Chair)

1998-present Professor of Nutrition, University of North Carolina

1993-present Professor of Cell & Molecular Physiology and Pediatrics (tenured), University of North Carolina

Awards

Freshman Medical Class Teaching Award, 1998, 1994, 1993, 1990; University Professor of Distinguished Teaching, 1995; Hyman L. Battle Medical Teaching Award, 1994; Kaiser Permanente Teaching Award, 1994; Ruth and Paul Hettleman Award for Scholarly Research, 1990

Professional Duties

Assoc. Editor Gastroenterology 2001-2005

Member American Gastroenterology Association Research Committee

B. Selected peer-reviewed publications

1. Ulshen MH, Dowling RH, Fuller RC, Zimmermann E, Lund PK. Enhanced growth of small bowel in transgenic mice overexpressing bovine growth hormone. Gastroenterology 1993;104:973-980.

2. Zimmermann E, Sartor B, McCall RD, Pardo M, Bender D, Lund PK. IGF-I and IL-1b messenger RNA in a rat model of granulomatous enterocolitis and hepatitis. Gastroenterology 1993;105:399-409.

3. McCall RD, Haskill S, Zimmermann EM, Lund PK, Sartor RB. IL-1 and IL-1 receptor antagonist are differentially expressed in rat strains variably susceptible to experimental enterocolitis. Gastroenterology 1994;106:960-972

4. Winesett DE, Ulshen MH, Hoyt EC, Mohapatra NK, Fuller CR, Lund PK. Regulation and localization of the insulin-like growth factor system in small bowel during altered nutrient status. Am J Phys. 1995;268 G631-G640.

5. Simmons JG, Hoyt EC, Westwick JK, Brenner DA, Pucilowska JB, Lund PK. Insulin-like growth factor-I (IGF-I) and epidermal growth factor (EGF) interact to regulate growth and gene expression in IEC-6 intestinal epithelial cells. Mol Endocrinol. 1995;9:1157-1165.

6. van Tol EAF, Petrusz P, Lund PK, Yamauchi M, Sartor RB Local production of corticotropin releasing hormone in experimental intestinal inflammation in rats. Gut 1996;39:385-92.

7. Ulshen MH, Hoyt EC, Fuller CF, Ghatei M. Bloom SR, Lund PK. Increased ileal proglucagon expression after jejunectomy is not suppressed by inhibition of bowel growth. Digestive Diseases and Sciences 1996;41(4):677-683.

8. Hoyt EC, Lund PK, Winesett DE, Fuller CF, Ghatei MA, Bloom SR, Ulshen MH. Effects of fasting, refeeding and intraluminal triglyceride on proglucagon expression in jejunum and ileum. Diabetes 1996;45:434-439

9. Lund PK, Zimmermann EM. Insulin-like growth factors and inflammatory disease.

In: Cytokines and Growth Factors in Gastroenterology. Goodlad R and Wright N eds. Bailliere's Clinical Gastroenterology, London. 1996;10,pp:83-96

10. Ohneda K, Ulshen MH, Fuller CF, D'Ercole AJ, Lund PK. Enhanced growth of small bowel in transgenic mice that overexpress human insulin-like growth factor I. Gastroenterology 1997;112:444-454

11. Savendahl L, Underwood LE, Haldeman KM, Lund PK. Fasting prevents experimental murine colitisproducedby dextran sulfate sodium and decreases interleukin-1b and insulin-like growth factor -I messenger RNA. Endocrinology 1997;138:734-740

12. Lund PK. The alpha-smooth muscle actin promoter: A useful tool to analyse autocrine and paracrine roles of mesenchymal cells in normal and diseased bowel. Gut 1998;42:320-322.

13. Simmons JG, Pucilowska JB, Lund PK. Autocrine and paracrine actions of intestinal fibroblast-derived insulin-like growth factors (IGFs). Am J Physiol 1999;(Gastrointest. Liver Physiol. 39) 276:G817-G827.

14. van Tol EAF, Holt L, Li FL, Kong F, Rippe R, Yamauchi M, Pucilowska J, Lund PK, Sartor RB. Bacterial cell wall polymers promote intestinal fibrosis by direct stimulation of myofibroblasts. Am. J. Physiol. 1999;277(Gastrointest. Liver Physiol.40):G245-G255.

15. Pete G, Fuller CR, Oldham JM, Smith DR, D’Ercole AJ, Kahn CR, Lund PK. Post-natal Growth Responses to IGF-I in IRS-1 Deficient Mice. Endocrinology 1999;140:5478-5487.

16. Lund PK. Insulin-like factors: Gene and mRNA structure and regulation. In: Handbook of Physiology; Hormonal Control of Growth. Kosty OJ ed. Oxford University Press, 1999;pp:537-571.

17. Lund PK. IGFs and the digestive tract. In: The insulin-like growth factors system. Roberts CT, Rosenfeld R eds. Humana Press 1999;pp:517-544.

18. Pucilowska JB, Williams KL, Lund PK. Fibrosis and inflammatory bowel disease: Cellular mediators and animal models. Am J. Physiol. 2000. 279, 9653-9659.

19. Pucilowska JB, Mohapatra NK, McNaughton KK, Hoyt EC, Sartor RB, Lund PK. IGF-I and procollagen a1(I) are co-expressed in a subset of mesenchymal cells in active CD. Am J. Physiol. 2000 279 G1307-1322.

20. Williams KL, Fuller CR, Dieleman LA, DaCosta CM, Haldemann KM, Sartor RB, Lund PK. Enhanced survival and mucosal repair following dextran sodium sulfate-induced colitis in transgenic mice that overexpress growth hormone. Gastroenterology, 2001 120 925-937.

21. Lund PK, Zuniga CC. Intestinal fibrosis in human and experimental inflammatory disease. Current Opinion in Gastroenterology 2001, 17:318-323.

22. Smith DR, Hoyt EC, Gallagher M, Scwhabe R. Lund PK Effect of age and cognitive status on basal level AP-1 activity in rat hippocampus. Neurobiology of Aging 2001 22 773-786.

23. Bizon JL, Han JS, Chun HJ, Pucilowska J, Lund PK, Gallagher M. Evaluation of hypothalamic-pituitary-adrenal axis function and hippocampal glucocorticoid receptor expression in behaviorally characterized young and aged rats. Euro J Neuroscience 2001 14 1739-1751.

24. Nicolle M, Gonzalez J, Sugaya K, Bryan D, Lund PK, Gallagher M, McKinney M. Signatures of hippocampal oxidative stress in aged spatial learning-impaired rodents Neurosci 2001 107 415-431.

25. Gillingham MB, Kritsch KR, Huss DJ, Murali SG, Lund PK, Ney D. Resection upregulates the IGF-I system of parenterally fed rats with jejunocolic anastomosis. Am J Physiol 2001 281 G1158-1168.

26. Wilkins HR, Ohneda K, Keku TO, D'Ercole AJ, Fuller CR, Williams KL, Lund PK Reduction of spontaneous and irradiation-induced apoptosis in the small intestinal mucosa of IGF-I transgenic mice. Am J Physiol 2002 283 G457-464.

27. Ye P, Lund P K, D’Ercole AJD Deficient expression of insulin-receptor substrate –1 (IRS-1) fails ro block insulin-like growth factor (IGF-I) stimulation of brain growth and myelination. Brain Research 2002 136 111-121.

28. Williams KL, Fuller CR, Fagin J, Lund PK Mesenchymal IGF-I overexpression: paracrine effects in the intestine, distinct from endocrine actions. Am. J Physiol Gastrointest Liver Physiol 2002 283: G875-G885.

29. Simmons JG, Pucilowska JB, Keku T, Lund PK. Insulin-like growth factor I an transforming growth factor beta have distinct effects on phenotype and proliferation of CCD 18Co intestinal myofibroblasts. Am J Physiol 2002 283 G809-818.

30. Martin C, Connelly A, Keku TO, Thomas S, Galanko J, Woosley JT, Schilebe B, Lund PK, Sandler RS. NSAIDs, apoptosis, and colorectal adenomas. Gastroenterology 2002 123: 1770-1777.

31. Greenhalgh CJ, Miller ME, Hilton DJ, Lund PK, The suppressors of cytokine signaling (SOCS) proteins : negative regulators of cytokine signaling cascades : relevance to gastrointestinal function and disease. Gastroenterology 2002 123, 2064-2081.

32. Connelly AE, Satia-Abouta J, Martin CF, Keku TO, Woosley JT, Lund PK, Sandler RS. Vitamin C intake and apoptosis in normal rectal epithelium. Cancer Epidemiol Biomarkers Prev. 2003 Jun;12(6):559-65.