Degrees
     B.S.:
        Queens College
        Flushing, New York (1949)
     MD:
        Harvard Medical School
        Boston, MA (1953)
     Residency:
        Peter Bent Brigham Hospital
        Boston, MA (1960)
     Fellowship:
        Mt. Sinai Hospital
        New York, NY (1954-55)
        Research Fellow in Medicine,
                  Harvard Medical School
        Assistant in Medicine, Peter Bent Brigham
                  Hospital, Boston, MA (1958-59)

Phone:   919-966-0774
email:   pwspar@med.unc.edu

Recent Publications:

Alexis, N., M. Eldridge, W. Reed, P.A. Bromberg, D. Peden. CD14-Dependent airway PMN response to inhaled LPS: Role of Atopy. J Allergy Clin Immunology 107:31-5, 2001.

Samet J.M., G.E. Hatch, D. Horstman, S.E. Steck, L. Arab, P.A. Bromberg, M. Levine, R.B. Devlin. Effect of antioxidant supplementation on ozone-induced lung injury in human subjects. Am. J. Respir. Crit. Care Med., 164:819-825, 2001.

Johnson T.A., R.B. Devlin., A.J. Ghio, Y-C T. Huang, D.L. Costa, C.L. Engle, P.A. Bromberg, W.E. Cascio. Cardiopulmonary effects of nebulized residual oil fly ash in anesthetized pigs. In INIS Monograph Series-Crucial Issues in Inhalation Research – Mechanistic, Clinical and Epidemiologic. U. Heinrich and U. Mohr, eds, Fraunhofer IRB Verlag, Stuttgart, Germany, 2002, pg 199-212.

Riediker M., R. Williams, R. Devlin, T. Griggs, P.A. Bromberg. Exposure to particulate matter, volatile organic compounds, and other air pollutants inside patrol cars. Environ. Sci. Technol. 37:2084-2093, 2003.

Hazucha M.J., L.J. Folinsbee, P.A. Bromberg. Distribution and reproducibility of spirometric response to ozone by gender and age. J. Appl. Physiol 85:1917-1925, 2003.

Boehlecke B., M. Hazucha, D. Peden, R. Jacobs, N. Alexis, P. Reist, P.A. Bromberg. Low-dose endotoxin enhances bronchial responsiveness to inhaled allergen in atopic asthmatics. J. Allergy Clin. Immunol, 112:1241-3, 2003.

Wu W., J.M. Samet, Silbajoris R., Dailey L., Sheppard D. P.A. Bromberg . Graves L. Heparin-binding EGF cleavage mediates zinc-induced EGF receptor phosphorylation. Am J Respir Cell Molec Biol. 30:540-7, 2004.

Riediker M., Cascio W., Griggs T., Herbst M., P.A. Bromberg, Neas L., Williams R., Devlin R. Particulate matter exposure in cars is associated with cardiovascular effects in healthy young men. Am. J. Resp.Crit. Care Med. 169:934-40, 2004.

Alexis N.E., S. Becker, P.A. Bromberg, R.B. Devlin, D.B. Peden. Circulating CD11b expression correlates with the neutrophil response and airway mCD14 expression is enhanced following ozone exposure in humans. Clin.Immunol 111:126-31, 2004.

Riediker M., R.B. Devlin, T.R. Griggs, M.C. Herbst, P.A. Bromberg, R.W. Williams, W.E. Cascio. Cardiovascular effects in patrol officers are associated with fine particulate matter from brake wear and engine emissions. Particle and Fibre Toxicology 1:2, 2004.

Riediker M, M. Herbst, R. Devlin, T. Griggs, P. Bromberg, W. Cascio. Effect of the September 11, 2001 Terrorist attack on a state highway patrol trooper’s heart rate variability. Ann Noninvasive Electrocardiol. 10 (1): 83-85, 2005.

Alexis, N., J.C. Lay, M. Almond, P.A. Bromberg, D. Patel, D.B. Peden. Acute LPS inhalation in healthy volunteers induces dendritic cell maturation in vivo. Journal of Allergy and Clinical Immunology, 115:345-350, 2005.

Wu W., R. Silbajoris, W. Zhang, Y.E. Whang, L.M. Graves, P.A. Bromberg, J.M. Samet. p38 and EGF receptor Kinase-mediated Activation of the Phosphatidylinositol 3-kinase/Akt Pathway Is Required for Zn2+-induced Cyclooxygenase-2 Expression. Am J Respir Cell Molec Biol. In press, 2005.

Reed William, A. J. Ghio, P. A. Bromberg, A. M. Collier, D. B. Peden. Interleukin-13 acting directly on human bronchial epithelial cells suppresses ciliated cell differentiation. Submitted.

Wu W., R. Silbajoris, M. Madden, Y.M. Kim, I. Jaspers, W. Zhang, L.M. Graves, P.A. Bromberg, J.M. Samet. Transcriptional and post-transcriptional regulation of COX-2 expression in human airway epithelial cells exposed to zinc ions. In preparation, 2005.

Wu W., L.M. Graves, P.A. Bromberg, J.M. Samet. Transactivation of nuclear transcription factors AP-1 and NFkB in zinc-treated cells. In preparation, 2005.

Selgrade MK, R.F. Lemanske, M.Ian Gilmour, L.M. Neas, M. Ward, P.K. Henneberger, D.N. Weissman, J.A. Hoppin, R.R. Dietert, P.D. Sly, A.M. Geller, P.L. Enright, G.S. Backus, P.A. Bromberg, D. Germolec, K.B. Yeatts. “Induction of asthma and the environment: What We Know and Need to Know”. Environmental Health Perspectives. Submitted.

Yeatts KB, M.J. Selgrade, P. Enright, F. Martinez, S. Shore, P. Sly, S. Weiss, D.N. Weissman, A.M. Geller, P.A. Bromberg, H. Koren. “Susceptibility factors influencing Asthma induction and incidence”. Environmental Health Perspectives. Submitted.

Chapters/Reviews

Weil, J., S. Crawford, P.A. Bromberg . “Pulmonary Complications of Hematologic Disease”. Textbook of Respiratory Medicine, 3 rd ed. Eds, Murray JF and Nadel JA. Chapter 86. WB Saunders Co, Philadelphia . pp. 2285-2308, 2000.

Bromberg PA, T. Chinet. “La pollution atmosphérique: Facteur de risque respiratoire et sa prévention (Air pollution: Risk factor for respiratory disease and its prevention). In, Pneumologie pour le praticien (Respiratory medicine for the practitioner) . Ed., GJ Huchon, Paris , pp. 28-32, 2001.

Cascio WE , P.A. Bromberg , M. Hazucha, R.B. Devlin. "Cardiovascular Effects of Air Pollutants". In Netter's Cardiology, 1 st ed . Eds. Runge, M and Ohman, M., Icon Learning Systems, Teterboro , New Jersey . Chapter 65, pp. 627-631, 2004.

Wu W., P.A. Bromberg , J.M. Samet. Signal transduction and zinc inhalation toxicology. In preparation.

Clinical Contact         Phone: (919) 966-2531 Fax: (919) 966-7013 130 Mason Farm Rd. CB #7020 The Univ. of North Carolina Chapel Hill, NC 27599-7020

Research Contact       Phone: (919) 966-1077 Fax: (919) 966-5178 7011 Thurston-Bowles Bldg. CB #7248 The Univ. of North Carolina Chapel Hill, NC 27599-7248