Hirotoshi
Matsui
Research Assistant Professor of Medicine
Degrees
Ph.D. (Doctor of Medical Science)
1999
University of Tokyo
M.D.
1989
University of Tokyo,
School of Medicine, Tokyo,
Japan
Medical
Staff
1997 Geriatric Medicine
University of Tokyo Hospital
Post Doctoral Fellow
1994 CF Center
Univ. of North Carolina at
Chapel Hill
Residency
1989 Internal Medicine
University of Tokyo Hospital
Tokyo, Japan
Office: 6007A Thurston-Bowles
Building
Phone: 919-966-8092
Fax: 919-966-7524
Email: hmatsui@med.unc.edu
Research Interests:
My research interests cover all aspects of pulmonary medicine, from lung sound to molecular pathophysiology of cystic fibrosis pulmonary diseases, to aspiration pneumonia in the elderly. My current research is focused on the lung defense mechanisms, which are impaired in cystic fibrosis patients.
Publications:
Matsuse T. Matsui H. Shu CY. Nagase T. Wakabayashi T. Mori S. Inoue S. Fukuchi Y. Orimo H. Adenovirus pulmonary infections identified by PCR and in situ hybridisation in bone marrow transplant recipients. J Clin Pathol. 47: 973-7, 1994
Matsuse T. Fukuchi Y. Matsui H. Sudo E. Nagase T. Orimo H. Effect of cigarette smoking on pulmonary function in each phenotype M of alpha-1-protease inhibitor. Chest. 107: 395-400, 1995
Matsuse T. Fukuchi Y. Eto Y. Matsui H. Hosoi T. Oka T. Ohga E. Nagase T. Orimo H. Expression of immunoreactive and bioactive activin A protein in adult murine lung after bleomycin treatment. Am J Respir Cell & Mol Biol. 13:17-24, 1995
Nagase T. Fukuchi Y. Matsui H. Aoki T. Matsuse T. Orimo H. In vivo effects of endothelin A- and B-receptor antagonists in guinea pigs. Am J Physiol. 268: L846-50, 1995
Nagase T. Fukuchi Y. Matsuse T. Sudo E. Matsui H. Orimo H. Antagonism of ICAM-1 attenuates airway and tissue responses to antigen in sensitized rats. Am J Respir Crit Care Med 151: 1244-9, 1995
Honda M. Hu PC. Huang CH. Matsui H. Lemon SM. A replication-deficient adenovirus enhances liposome-mediated nucleic acid transfer into a stable cell line expressing T7 RNA polymerase. J Virol Methods. 58: 41-51, 1996
Matsuse T, Fukuchi Y, Hsu CY, Nagase T, Higashimoto N, Teramoto S, Matsui H, Sudo E, Kida K, Morinari H, Fukayama M, Ouchi Y, Orimo H Detection of human T lymphotropic virus type I proviral DNA in patients with diffuse panbronchiolitis. Respirology 1: 139-144, 1996
Nagase T, Matsui H, Aoki T, Ouchi Y, Fukuchi Y Lung tissue behavior in the mouse during constriction induced by methacholine and endothelin1. J Appl Physiol 81: 2373-2378, 1996
Nagase T. Matsui H. Sudo E. Matsuse T. Ludwig MS. Fukuchi Y.Effects of lung volume on airway resistance during induced constriction in papain-treated rabbits. J Appl Physiol 80(6):1872-9, 1996.
Nagase T, Aoki T, Matsui H, Ohga E, Katayama H, Teramoto S, Matsuse T, Fukuchi Y, Ouchi Y Airway and lung tissue behavior during endothelin-1 induced constriction in rats: effects of receptor antagonists. Can J Physiol Pharmacol 75; 1369-1374, 1997
Matsui H. Johnson LG. Randell SH. Boucher RC. Loss of binding and entry of liposome-DNA complexes decreases transfection efficiency in differentiated airway epithelial cells. J Biol Chem. 272: 1117-26, 1997
Matsui H, Grubb BR, Tarran R, Randell SH, Gatzy JT, Davis CW, Boucher RC. Evidence for periciliary liquid layer depletion, not abnormal ion composition, in the pathogenesis of cystic fibrosis airways disease. Cell, 95: 1005-1015, 1998
Matsui H, Randell SH, Peretti SW, Davis CW, Boucher RC. Coordinated clearance of periciliary liquid and mucin from airway surfaces. J Clin Invest 102: 1125-1131, 1998
Hoganson DK, Matsui H, Batra RK, Boucher RC. Toxin gene-mediated growth inhibition of lung adenocarcinoma in an animal model of pleural malignancy. Human Gene Ther 9: 1143-1156, 1998
Pickles RJ, McCarty D, Matsui H, Hart PJ, Randell SH, Boucher RC. Limited entry of adenovirus vectors into well-differentiated airway epithelium is responsible for inefficient gene transfer. J Virol 72: 6014-6023, 1998
Teramoto S, Matsuse T, Matsui H, Ohga E, Ishii T, Ouchi Y. Recombinant E1-deleted adenovirus vector induces apoptosis in two lung cancer cell lines. Eur Respir J 13:1125-32 , 1999
Teramoto S, Matsuse T, Matsui H, Ohga E, Ishii T, Nagase T, Ouchi Y. Recombinant E1-deleted adenoviral vectors induce apoptosis in a rat airway epithelial mucous goblet cell line. Jpn J Pharmacol 81:73-8 , 1999
Teramoto S, Tomita T, Matsui H, Ohga E, Matsuse T, Ouchi Y. Hydrogen peroxide-induced apoptosis and necrosis in human lung fibroblasts: protective roles of glutathione. Jpn J Pharmacol 79:33-40, 1999
Teramoto S, Suzuki M, Matsui H, Ishii T, Matsuse T, Ouchi Y. Influence of age on diurnal variability in measurements of spirometric indices and respiratory pressures. J Asthma 36:487-92 , 1999
Teramoto S, Suzuki M, Ohga E, Ishii T, Matsui H, Matsuse T, Ouchi Y. Effects of ambroxol on spontaneous or stimulated generation of reactive oxygen species by bronchoalveolar lavage cells harvested from patients with or without chronic obstructive pulmonary diseases. Pharmacology 59:135-41 , 1999
Ishii T, Matsuse T, Teramoto S, Matsui H, Miyao M, Hosoi T, Takahashi H, Fukuchi Y, Ouchi Y. Glutathione S-transferase P1 (GSTP1) polymorphism in patients with chronic obstructive pulmonary disease. Thorax 54: 693-6, 1999
Ishii T, Matsuse T, Teramoto S, Matsui H, Hosoi T, Fukuchi Y, Ouchi Y. Association between alpha-1-antichymotrypsin polymorphism and susceptibility to chronic obstructive pulmonary disease. Eur J Clin Invest. 30:543-8, 2000
Matsui H, Davis CW, Tarran R, Boucher RC. Osmotic water permeabilities of cultured, well-differentiated normal and cystic fibrosis airway epithelia. J Clin Invest. 105:1419-27, 2000
 |
 |
Clinical Contact
|
Research Contact
|