Larry Ostrowski
Associate Professor of Medicine
Degrees
BA:
(1980) Northwestern U.
Evanston IL
PhD:
(1986) Loyola U.
Chicago IL
Office:
242 Thurston-Bowles
Phone: 919-963-7177
Fax: 919-966-7013
email:
ostro@med.unc.edu
Research Interests:
- Gene therapy of cystic fibrosis
- Structure, function, and regulation of cilia in mucociliary clearance
- Pathogenesis and treatment of Primary Ciliary Dyskinesia (PCD)
- Regulation of ciliogenesis in the airways
Selected Publications and Chapters
Ostrowski LE, Andrews KL, Potdar PD, Nettesheim P. Ciliated-cell differentiation and gene expression. Protoplasma 206:245-248, 1999.
Andrews KL, Potdar P, Nettesheim P, Ostrowski LE. KPL1, which encodes a novel PH domain-containing protein, is induced during ciliated cell differentiation of rat tracheal epithelial cells. Exp Lung Res 26(4):257-271, 2000.
Zhang YJ, O'Neal W, Randell SH, Blackburn K, Moyer M, Boucher RC, Ostrowski LE. Identification of dynein heavy chain 7 as an inner arm component of human cilia that is synthesized but not assembled in a case of primary ciliary dyskinesia. J Biol Chem 277(20):17906-15, 2002.
Ostrowski LE, Blackburn K, Radde KM, Moyer MB, Schlatzer DM, Moseley A, Boucher RC. A proteomic analysis of human cilia: identification of novel components. Mol Cell Proteomics 1(6):451-465, 2002.
Kultgen PL, Byrd SK, Ostrowski LE, Milgram SL. Characterization of an A-Kinase anchoring protein in human ciliary axonemes. Mol Biol Cell 13:4156-4166, 2002.
Ostrowski, LE, Hutchins, JR, Zakel, K, O'Neal, W. Targeting expression of a transgene to the airway surface epithelium using a ciliated cell-specific promoter. Mol. Therapy 8: 637-645, 2003.
Zariwala, M, O'Neal, W, Noone, PG, Leigh, MW, Knowles, MR, Ostrowski, LE. Investigation of the possible role of a novel gene, DPCD, in Primary Ciliary Dyskinesia. Am J Respir Cell Mol Biol 30:428-434, 2004.
Ostrowski LE. Molecular strategies for the study of human cilia. In: Salathe M, Satir P, Adler K, Boucher R, editors. Cilia, Mucus, and Mucociliary Interactions. New York: Marcel Dekker, Inc., 2001: 127-132.
Ostrowski LE. Ciliogenesis of the airway epithelium. In: Chernick V, Haddad GG, Abman SH, editors. Basic Mechanisms of Pediatric Respiratory Disease. Hamilton: B. C. Decker Inc., 2002: 452-464.
Ostrowski, LE. Preparation of cilia from human airway epithelial cells. In:Celis, JE, editor. Cell Biology: A Laboratory Handbook. San Diego: Elsevier Science, 2004, in press.
Ostrowski, LE, Bennett, WD. Cilia and mucociliary clearance. In: Laurent, G. Shapiro, S., editors. Encyclopedia of Respiratory Medicine. San Diego: Elsevier Science, 2004, in press.
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