James Yankaskas
Professor of Medicine

Degrees
    BS: 
    (1969) MIT
    Cambridge MA
   MS: 
    (1972) New York U.
    New York NY
   MD: 
    (1978) U. of Connecticut School of Med
    Farmington CT
  Internship and Residency: 
    (1978-81) Internal Medicine
    U. of North Carolina
    Chapel Hill NC
   Clinical Fellowship: 
    (1981-82) Duke U. Medical Center
    Durham NC
  Research Fellowship: 
    (1982-84) U. of North Carolina
    Chapel Hill NC

    

Office:   7007 Thurston-Bowles Bldg.
Phone:  919-966-7054
Fax:      919-966-7524
email:   James_Yankaskas@med.unc.edu

Research Interests:

1. Physiology of human airway epithelia. Fresh tissues and cell culture models are used to evaluate gene expression and physiological functions of surface epithelia and submucosal glands from normal and diseased tissues.
2. Cystic fibrosis in adults. Basic science and clinical studies of disease pathophysiology, treatment and outcomes.
3. Clinical research databases. Development of relational databases that will facilitate the investigation of genetic, environmental and treatment effects of the course of chronic lung diseases.

Recent Publications:
2000 - present

N. Sood, L.J. Paradowski, and J.R. Yankaskas. Outcomes of intensive care unit care in adults with cystic fibrosis. Am. J. Respir. Crit. Care Med. 163:335-338, 2001.

L. Gao, J.R. Yankaskas, C.M. Fuller, E.J. Sorscher, S. Matalon, H.J. Forman, and C.J. Venglarik. Chlorzoxazone or 1-EBIO increases Na + absorption across cystic fibrosis airway epithelial cells. Am. J. Physiol. 281: L1123-L1129, 2001.

S.H. Randell, D.L. Walstad, U.E. Schwab, B.R. Grubb, and J.R. Yankaskas. Isolation and culture of airway epithelial cells from chronically infected human lungs. In Vitro Cell Dev Biol Anim. 2001; 37:480-489.

A. D. Betensley, J. R. Yankaskas. Factor VIIa for alveolar hemorrhage in microscopic polyangiitis. (Letter). Am J Respir Crit Care Med 2002; 166:1291-2.

J. Mungle, E. H. Burker, J. R. Yankaskas. Vocational rehabilitation counseling for adolescents and adults with cystic fibrosis. J. Applied Rehabilitation Counseling. 2002; 33:15-21.

U. Schwab, M. Leigh, C. Ribeiro, J. Yankaskas, K. Burns, P. Gilligan, P. Sokol, R. Boucher. Patterns of epithelial cell invasion by different species of the Burkholderia cepacia complex in well-differentiated human airway epithelia. Infect Immun. 2002; 70:4547-55.

D. Worlitzsch, R. Tarran, M. Ulrich, U. Schwab, A. Cekici, K. C. Meyer, P. Birrer, G. Bellon, J. Berger, T. Weiss, K. Botzenhart, J. R. Yankaskas, S. Randell, R. C. Boucher, G. Doring. Effects of reduced mucus oxygen concentration in airway Pseudomonas infections of cystic fibrosis patients. J Clin Invest. 2002; 109:317-325.

J. C. Lay, M. R. Stang, P. E. Fisher, J. R. Yankaskas, W. D. Bennett. Airway retention of materials of different solubility following local intrabronchial deposition in dogs. J. Aerosol Medicine 2003: 16:153-166.

J. R. Yankaskas*, B. C. Marshall*, B. Sufian, R. H. Simon, and D. Rodman. Cystic Fibrosis Adult Care – Consensus Conference Report. Chest 2004; 125:1S-40S.

M. Mall, S. M. Kreda, A. Mengos, T. J. Jensen, S. Hirtz, H. H. Seydewitz, J. Yankaskas, K. Kunzelmann, J.R. Riordan, R.C. Boucher. The D F508 mutation results in loss of CFTR function and mature protein in native human colon. J. Clin Invest 2004. Gastroenterology. 2004;126:32-41.

M. Nissim-Rafinia, M. Aviram, S.H. Randell, L. Shushi, E. Ozeri, O. Chiba-Falek, O. Eidelman, H.B. Pollard, J.R. Yankaskas, B. Kerem. Restoration of the cystic fibrosis transmembrane conductance regulator function by splicing modulation. EMBO Rep. 2004; 5:1071-1077.

M.L. Fulcher, S. Gabriel, K.A. Burns, J.R. Yankaskas, S.H. Randell. Well-differentiated human airway epithelial cell cultures. Methods Mol Med. 2005;107:183-206.

S.M. Kreda, M. Mall, A. Mengos, L. Rochelle, J. Yankaskas, J.R. Riordan, R.C. Boucher. Characterization of Wild-Type and {Delta}F508 Cystic Fibrosis Transmembrane Regulator in Human Respiratory Epithelia. Mol Biol Cell. 2005 Feb 16; [Epub ahead of print]

Flume PA, Yankaskas JR, Ebeling M, Hulsey T, Clark LL.  Massive hemoptysis in
cystic fibrosis.  Chest 2005; 128: 729-738.

Non-Refereed Journals and Book Chapters

JR Yankaskas and MR Knowles, editors. Cystic Fibrosis in Adults. Lippincott-Raven Publishers, Philadelphia, 1999.

JR Yankaskas. Bronchitis, bronchiectasis and cystic fibrosis. In: Infectious Diseases, Vol. 1, David Armstrong and Jonathan Cohen, editors. Mosby and Company, Section 2: 26.1-26.8, 1999.

RC Boucher, MR Knowles, and JR Yankaskas. Cystic fibrosis. In: Textbook of Respiratory Medicine, 3rd Edition, J Murray and J Nadel, editors. WB Saunders Co., Philadelphia, pp. 1291-1323, 2000.

JR Yankaskas. Cystic fibrosis. In: Respiratory Infections, 3rd Edition, MS Niederman, GA Sarosi, and J Glassroth, editors. Lippincott Williams & Wilkins, Philadelphia, pp. 283-296, 2001.

LH Burch, JM Rommens, JR Yankaskas, LC Tsui and RC Boucher. Alternative initiation and splicing produce tissue-specific mRNAs. Pediatr Pulmonol. Suppl. 19:172, 1999.

L Gao, KJ Kim, JR Yankaskas and HJ Forman. Abnormal glutathione (GSH) release into apical fluid of cystic fibrosis airway epithelium. ICSDT: The First International Conference on Control and Diseases of Sodium Dependent Transport Proteins and Ion Channels (Shizuoka, Japan, August 24-28, 1999) (In Press).

BJ Pearce and JR Yankaskas. Ciliated ducts are abnormal in cystic fibrosis airway submucosal glands. Pediatr Pulmonol. Suppl. 19:257, 1999.

LG Rochelle, JT Gatzy, JR Yankaskas, and RC Boucher. The role of submucosal gland ducts in airway secretions. Pediatr Pulmonol. Suppl. 19:256, 1999.

SW Miller, MN Becker, SH Bernacki, AL Nelson, JR Yankaskas and SH Randell. Clara cell genes and proteins in human bronchiolar epithelial cell cultures. Am J Respir Crit Care Med. 161:A150, 2000.

JR Yankaskas. Pro: Antibiotic resistant infections should prevent lung transplant in CF. Pediatr Pulmonol. Suppl. 20:163, 2000.

L Gao, JR Yankaskas, HJ Forman and CJ Venglarik. 1-EBIO or chlorzoxazone increases amiloride-sensitive Na+ absorption across cystic fibrosis airway epithelial cells. Pediatr Pulmonol. Suppl. 20:203, 2000.

LG Rochelle, JT Gatzy, JR Yankaskas and RC Boucher. Ion flow across excised CF and non-CF human bronchi. Pediatr Pulmonol. Suppl. 20:208, 2000.

U Schwab, P Gilligan, R Boucher, S Randell and J Yankaskas. Localization of Burkholderia cepacia in well-differentiated human tracheobronchial epithelial cultures. Pediatr. Pulmonol. Suppl. 20:277, 2000.

Clinical Contact         Phone: (919)966-2531 Fax: (919)966-7013 130 Mason Farm Rd. CB# 7020 The Univ. of North Carolina Chapel Hill, NC 27599-7020

Research Contact        Phone: (919)966-1077 Fax: (919)966-7524 7011 Thurston-Bowles Bldg. CB# 7248 The Univ. of North Carolina Chapel Hill, NC 27599-7248