| Name |
Keywords |
Research Interests |
| Bhat, Manzoor |
Axon, Node of Ranvier, glia, drosophila, mice, neurexin |
Genetic Dissection of Axon-Glial Interactions in Drosophila and Mice |
| Deshmukh, Mohanish |
apoptosis, cell death, neurodegeneration, development, survival, nerve growth factor, transgenic mice |
Molecular mechanism of apoptosis in neurons. |
| Gilmore , John |
dopamine, schizophrenia, imaging, FMRI, human, virus, development, |
Developmental regulation of dopamine receptor function in humans. Role of maternal viral infections in brain development. |
| Goy, Michael |
second messengers; cyclic GMP; synaptic modulation; neuromuscular physiology |
Regulation of cyclic nucleotide function in neuromuscular, CNS, and gastrointestinal systems |
| Harden, T. Kendall |
G proteins, phospholipase C, RGS proteins, P2Y receptors, ecto-nucleotidase, protein structure/function, molecular pharmacology |
Regulation of phospholipase C and inositol lipid signaling; Structure/function of RGS proteins; Biology of nucleotides and nucleotide sugars as extracellular signaling molecules |
| Hodge, Clyde |
drug addiction, pharmacology, behavior, neural circuits, genetics, receptors |
Behavioral neurobiology and pharmacogenomics of drug abuse: Neural circuits and genes that mediate drug, self-administration and discrimination. |
| Hong, Jau-Shyong |
opioid peptides; neurotransmitters; gene expression; bovine adrenal chromaffin cells; hippocampus; seizures |
Regulation of opioids and tachykinins in the nervous system at the cellular and molecular level |
| Lauder, Jean |
serotonin, neurotransmitters, neuronal and glial cultures, whole embryo culture, rats, mice, in situ hybridization, receptors, immunocytochemistry, antiidiotypic antisera, morphometry |
Serotonin and neuronal/glial differentiation in the rat CNS. |
| Lund, P Kay |
peptides, growth factors |
Regulation of the biosynthesis and expression of neuropeptides; function of growth factors in the CNS |
| Maixner, William |
pain, electrophysiology, pharmacology |
Pharmacological and physiological mechanisms underlying the control of pain; role of hemodynamic factors in nociception |
|
Maness, Patricia |
cell adhesion, development, oncogenes |
Oncogenes and their expression in the developing nervous system |
| Manis, Paul |
synaptic transmission, receptors, ion channels, potassium channels, spike-timing dependent plasticity, patch clamp, brain slice, single cell neural modeling, calcium imaging, quantitative real-time PCR, single cell PCR |
Cellular mechanisms of auditory information processing and plasticity. Studies examine ion channels and synaptic function and plasticity in the brainstem and cortex. |
| McCarthy, Kenneth |
glial cells, calcium signaling |
Regulation of intracellular calcium and glial cell function by neurotransmitter action; regulation of glial cell phenotype |
| Meeker, Rick |
neuroendocrine; supraoptic nucleus; pituitary; HIV; vasopressin; in situ hybridization; cholinergic receptors; AIDS dementia |
Immunocytochemistry and electrophysiology of vasopressin neuroendocrine cells of the hypothalamus |
| Morrow, A Leslie |
GABA-A receptor, mRNA regulation, ethanol, barbiturates, benzodiazepines, neuroactive steroids |
Molecular Neuropharmacology, Mechanisms of Receptor Regulation, Alcohol Research, GABA-A Receptors |
| Nicholas, Robert |
receptors, purinergic receptors, G-proteins |
Regulation and function of G-protein coupled receptors in the CNS |
|
Otey, Carol |
cytoskeleton, growth cone motility, astrocyte activation, glial scar, presynaptic plasticity, vesicle trafficking |
Regulation of actin cytoskeleton organization and its role in axonal outgrowth during development and after injury; changes in astrocyte morphology and motility in response to injury of the CNS. |
| Pedersen, Cort |
Maternal behavior, sexual behavior, oxytocin, neuropeptides. |
Peptide influences on maternal and sexual behavior; neurobiology of parenting behavior |
Perl, Edward
| pain, nocioception, brain slices, spinal cord, sensory processing |
Specificity of sensory systems; cellular and molecular correlates of nociceptive function in mammals |
|
| Philpot, Benjamin |
synaptic plasticity, visual system, ocular dominance, LTP, LTD, NMDA receptors, cortex |
We are studying how visual experience modifies the properties of synaptic plasticity (LTP and LTD) so that the visual world can be properly analyzed. We use brain slice preparations from transgenic mice. These studies will characterize how experience regulates the elementary properties of plasticity and excitatory synaptic transmission. |
|
Picker, Mitchell |
addiction, behavior, opiates |
Behavioral responses to chronic narcotic analgesic treatment |
| Polleux, Franck |
development, ephrins, cortex, signaling pathways |
Identification of the cues and signaling pathways underlying the development of connections in the mammalian cerebral cortex |
| Robinson, Donita |
alcoholism, electrophysiology, electrochemistry, behavior, neuropharmacology, neural circuits, dopamine, alcohol self-administration, drug addiction |
Cellular mechanisms underlying alcohol use in an animal model of alcohol self-administration: electrophysiological recordings at multielectrode arrays; electrochemical measurements of dopamine at microelectrodes; neuroadaptations induced by chronic alcohol exposure; pharmacotherapy for alcoholism. |
| Roth, Bryan |
Phramacology, G-proteins, serotonin, opoid receptors |
Serotonin (5-hydroxytryptamine; 5-HT) and opioid receptors are involved in the actions of drugs used in treating a large number of illnesses including depression, schizophrenia, anxiety, migraine headaches, pain and chemotherapy-induced nausea. Understanding how drugs bind to and regulate serotonin and opioid receptors will yield insights into designing novel medications for treating a large number of CNS diseases. |
| Rosenberg, Robert |
electrophysiology; ion channels; patch clamp; Xenopus oocytes; ionotropic receptors |
Molecular mechanisms of gating and ion permeation of nicotinic acetylcholine receptors |
| Rustioni, Aldo |
structure and cell biology of glutamate receptors and of actin-associated proteins |
Control of sensory input by presynapic glutamate receptors expressed by primary afferents to the spinal cord. The role of palladin, a newly discovered protein, in synaptic transmission and axonal sprouting in response to injury. |
| Sealock, Robert |
cytoskeleton; duchenne muscular dystrophy; dystrophin; membrane-cytoskeleton interaction; actin-binding proteins; protein chemistry; electron microscopy; freeze-etch; postsynaptic structure & cell biology |
Molecular mechanisms underlying acetylcholine receptor localization at neuromuscular junctions; the cytoskeleton of the muscle cell plasma membrane |
| Sockman, Keith |
auditory forebrain, behavior, birdsong, catecholamine, evolution, field biology, monoamine, neuroecology, neuroethology, reproduction |
Using songbirds as a study system, I take field and laboratory approaches to investigate the neural integration of ecological and social cues regulating life-history trade-offs and reproductive decisions such as mate-choice, courtship, reproductive timing, and reproductive effort. |
| Stuart, Ann |
visual system, synaptic transmission, histamine, biophysics |
Processing of visual information in a simple (invertebrate) nervous system; mechanisms of synaptic transmission from photoreceptors |
| Thiele, Todd |
addiction, alcohol, behavior, electrophysiology |
My primary research interests are directed at the neurobiology of alcoholism. To study the central mechanisms involved with neurobiological responses to ethanol, I use both genetic and pharmacological manipulations. |
| Valtschanoff, Juli |
neurotransmitter, spinal cord, somatosensory, nitric oxide, vanilloid, electron microscopy |
Dr. Valtschanoff's research interests are in neurotransmitters in the brain and spinal cord. Past studies have involved amino acid neurotransmitters and nitric oxide in the rat somatosensory system, combining immunocytochemical techniques at LM and EM level with tract tracing methods and models of altered neuronal activity. Recent reasearch has focused on glutamate receptors and their anchoring proteins, and the role of vanilloid receptors in the mediation of nociception in the dorsal horn of mammals. |
| Van Dyke, Terry |
genetics, cancer, glial, glioblastoma, transcription |
Regulatory mechanisms of cell-specific gene transcription and cell growth control |
| Weinberg, Richard |
dendritic spines, calcium, neuroanatomy, electron microscopy, spinal cord, cortex, synaptic transmission, neurotransmitters, glutamate, GABA |
My primary research interest is postsynaptic mechanisms of glutamatergic transmission. I want to understand glutamatergic signaling, especially its short- and longterm modulation. My group is now studying the structural organization of the postsynaptic density and the dendritic spine. |
| Weiss, Ellen |
G-Proteins, retina, signaling |
The research in my laboratory concerns the regulation of G protein signaling pathways. G-proteins are activated by a family of cell surface receptors known as G protein-coupled receptors (GPCRs). These receptors, all having seven transmembrane domains, are regulated by diverse environmental signals, including hormones, neurotransmitters, odorants, light and ions such as Ca2+. The level of G protein activity in cells is ultimately determined by the level of receptor stimulation and by several mechanisms that contribute to inhibition of G protein signaling. |
| Wightman, R Mark |
neurotransmitters; dopamine, norepinephrine, 5-hydroxytryptamine; in vivo measurements |
Real-time electrochemical measurements of neurotransmitter secretion in the rat brain |
| Zylka, Mark |
GPCRs, Neural circuitry, electrophysiology, behavior, molecular neurobiology |
Molecules and Mechanisms for Pain |
