Disproportionately high asthma morbidity and mortality exists among socioeconomically disadvantaged children living in urban areas. Growing evidence shows that exposure to chronic stress predicts future asthma exacerbations in children. However, the influence of neighborhood-level factors on stress and asthma morbidity among urban youth remains poorly understood. This mixed methods study utilized concept mapping methods to engage residents of two underserved communities as well as primary healthcare practitioners to identify and prioritize neighborhood factors that may influence, positively or negatively, childhood asthma. Findings provide key insight to breadth and influence of the impact of diverse social and structural influences upon childhood asthma and asthma disparities. Results will generate testable hypotheses regarding neighborhood influences on childhood asthma care and inform the design of behavioral and public health asthma care and control programs for youth.