Carolina Systems Genetics Seminar- Thursday, February 3 (Mark Heise)

Our research group is working with the Complex Trait Consortium to investigate how viruses interact with genetically complex populations. As part of this collaboration, we are utilizing the Collaborative Cross (CC) as a model system for studying viral interactions with genetically diverse populations and as a tool for identifying/studyiung polymorphic host genes that regulate susceptibility to virus-induced disease. Initial studies with influenza virus (IAV) and SARS coronavirus demonstrated that pre-CC mouse lines exhibit a more diverse range of phenotypes than the parental lines used to generate the CC, including phenotypes that may result in the development of improved models for virus-induced respiratory disease. Our initial study also identified novel QTLs associated with resistance/susceptibility to IAV or SARS-induced disease, thereby validating the CC as a model system for investigating pathogen interactions with genetically complex populations.

When Feb 03, 2011
from 03:00 PM to 04:00 PM
Where Room 0001, Hooker Research Building
Contact Name
Contact Phone 919-843-6367
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“ Bugs in the System: Using Systems Genetics to Study Virus-Host Interactions”

Mark Heise, PhD
Department of Genetics

UNC Chapel Hill

 

 

Thursday, February 3, 2011
3pm
Room 0001, Hooker Research Building

(Please note change in location)

 

 

 

Sponsored by:

The Center for Integrated Systems Genomics at UNC

An NHGRI P50 Center of Excellence in the Genome Sciences

Administered by the Carolina Center for Genome Sciences

 

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