Carolina Systems Genetics Seminar- Thursday, February 3 (Mark Heise)

Our research group is working with the Complex Trait Consortium to investigate how viruses interact with genetically complex populations. As part of this collaboration, we are utilizing the Collaborative Cross (CC) as a model system for studying viral interactions with genetically diverse populations and as a tool for identifying/studyiung polymorphic host genes that regulate susceptibility to virus-induced disease. Initial studies with influenza virus (IAV) and SARS coronavirus demonstrated that pre-CC mouse lines exhibit a more diverse range of phenotypes than the parental lines used to generate the CC, including phenotypes that may result in the development of improved models for virus-induced respiratory disease. Our initial study also identified novel QTLs associated with resistance/susceptibility to IAV or SARS-induced disease, thereby validating the CC as a model system for investigating pathogen interactions with genetically complex populations.

Event details

When

Feb 03, 2011
from 03:00 PM to 04:00 PM

Where

Room 0001, Hooker Research Building

Contact Name

Jennifer Brennan

Contact Phone

919-843-6367

Add event to calendar

vCal

iCal

“ Bugs in the System: Using Systems Genetics to Study Virus-Host Interactions”

Mark Heise, PhD
Department of Genetics

UNC Chapel Hill

Thursday, February 3, 2011
3pm
Room 0001, Hooker Research Building

(Please note change in location)