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VERSION:2.0
METHOD:PUBLISH
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DTSTAMP:20130518T104158Z
CREATED:20130315T201000Z
UID:ATEvent-de58e3b80c0f4c98922104b3c626edfb
LAST-MODIFIED:20130315T201002Z
SUMMARY:Chemical Exchange Sensitive MRI: Amide and Amine Protons
DTSTART:20130311T180000Z
DTEND:20130311T190000Z
DESCRIPTION:Abstract:\nImaging the pH and chemical compositions of the
  brain is important for understanding brain function and may provide u
 seful information in clinical applications of brain diseases.  Chemica
 l exchange of protons between water and biomolecules can be exploited 
 in magnetic resonance imaging (MRI) for measuring pH and metabolite/pr
 otein concentration changes which are detected indirectly through wate
 r signal with enhanced sensitivity by applying saturation or spin-lock
 ing radiofrequency pulses.  Exchangeable amide and amine protons are a
 bundant in the brain and have been shown to be promising chemical exch
 ange sites in preclinical studies of brain cancer and stroke.  In this
  talk\, I will present the physical principles and the quantification 
 and optimization issues of chemical-exchange sensitive MRI and discuss
  the in vivo signal source of MRI techniques sensitive to the amide- a
 nd amine–water proton exchange.
LOCATION:Medical Research Building D Conference Room
CONTACT:Ann Sherman\, 966-4397 \, ann_sherman@med.unc.edu
URL:http://bric.unc.edu/
CLASS:PUBLIC
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