High Resolution Label-Free In Vivo Molecular Imaging

BRIC Seminar Series Presented by Stephen Wong, Ph.D. Systems Medicine and Bioengineering Department, The Methodist Hospital Research Institute Houston, TX

When May 28, 2013
from 02:00 PM to 03:00 PM
Where 1131 Bioinformatics
Contact Name
Contact Phone 966-4397
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The clinical deployment of in vivo molecular imaging faces two major hurdles.  First, most in vivo molecular imaging techniques require the injection of exogenous contrast agents or labels into human body to aid detection, diagnosis, or targeted therapy.  The development of such imaging agents, however, is treated similar to the development of drugs by FDA and thus subjects to the lengthy and expensive process of FDA approval, yet contrast agents have much smaller market as drugs.  Second, the relatively low spatial resolution of current imaging modalities prevents them from detecting and visualizing molecular signatures and physiopathology changes at the cellular level in vivo for more precise and earlier intervention. In this talk, we present an alternate paradigm of in vivo molecular imaging based on the principle of label-free molecular vibrational imaging, in particular, coherent anti-Stokes Raman scattering (CARS) or Stimulated Raman Scattering (SRS), in order to sidestep the two hurdles.  We will discuss certain ongoing applications in our laboratory, such as image-guided intervention of peripheral lung cancer, nerve sparing robotic prostatectomy, tumor margin detection during lumpectomy, and neurovascular micro-ablation to illustrate the potential and practicality of this new class of label-free imaging devices.

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