Welcome to the Erickson Lab!

Cellular Biochemistry
Protein Targeting
Lysosomal Protein Biosynthesis

    We are characterizing the structural signals that are responsible for moving enzymes normally stored intracellularly in lysosomes into the extracellular environment, where they may serve physiological functions not normally ascribed to lysosomal proteases.

    Four proteins that potentially bind a lysosomal protease precursor in multivesicular endosomes, an endosome which can be induced to secrete its contents in specialized cells, are being characterized.

Principal Investigator: Ann Erickson
Department of Biochemistry and Biophysics
The University of North Carolina at Chapel Hill
416 Mary Ellen Jones Building
CB #7260
Chapel Hill, NC 27599-7269
Phone: 919-966-4694