to the Erickson Lab!
Lysosomal Protein Biosynthesis
We are characterizing the structural signals that
are responsible for moving enzymes normally stored intracellularly in
lysosomes into the extracellular environment, where they may serve physiological
functions not normally ascribed to lysosomal proteases.
Four proteins that potentially bind a lysosomal
protease precursor in multivesicular endosomes, an endosome which can
be induced to secrete its contents in specialized cells, are being characterized.
Principal Investigator: Ann Erickson
Department of Biochemistry and Biophysics
The University of North Carolina at Chapel Hill
416 Mary Ellen Jones Building
Chapel Hill, NC 27599-7269