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Postdoctoral positions to study the histone code and gene regulation

The Strahl lab provides a unique opportunity for inquisitive researchers to study the role of histone post-translational modifications (e.g. acetylation, methylation and ubiquitylation) in chromatin structure and function. We are employing a variety of different approaches (biochemical, genetic and proteomic) to address how these post-translational modifications contribute to gene transcription/DNA repair and how they work in combination to regulate a possible histone code (see Strahl and Allis, Nature 403:41-45, 2000 and Garnder, Allis, and Strahl, J of Mol Bio 409:36-46). Recent studies show that multiple and adjacent domains in chromatin-associated proteins work in combination to "readout “specific histone modification signatures to regulate fundamental biological processes such as DNA methylation (e.g., see Rothbart...Strahl, 2013 Genes & Development, 27:1288-98). Yet, the extent to which other histone-associated proteins function in this manner is poorly understood, and as such, is a significant area we are currently exploring.

 

We are continually seeking enthusiastic and highly motivated individuals with a strong publication background to join us in this very exciting field of study. A Ph.D. with molecular biology experience is required for the postdoctoral position. Additional experience in proteomics, microarray and/or yeast manipulation is preferred but not necessary as we seek individuals with high training potential.

 

It is important to mention that UNC offers an outstanding environment to carry out studies in the Strahl lab. There are a wide number of core facilities, expert epigenetic faculty to consult and collaborate with, and an extremely friendly living environment here in Chapel Hill. In addition, UNC harbors two outstanding postdoctoral training programs for which you can gain independent funding. One is the UNC Lineberger Cancer Center Postdoctoral Training Program, and the other the SPIRE training program (which is centered more so on teaching development). I strong encourage all of my trainee's to apply for these incredible training programs when joining the lab, which offer great training and career development opportunities. In all, UNC and my lab offer an outstanding place to train for a scientific career in the biomedical sciences.

 

If you are interested in pursuing research with our lab, please remit your CV, along with the names of 2-3 references, to Dr. Brian Strahl @ brian_strahl@med.unc.edu.