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from Tateishi et al. Nature 2009Jhdm2a-deficient mice exhibit obesity phenotypes
A. Jhdm2a knockout mice exhibit an obesity phenotype. Shown is a representative photograph of 7 month old littermates. B. Abnormal fat accumulation in organs of Jhdma -/- mice. Haematoxylin and eosin (H&E) staining of white adipose, muscle and liver derived from 7 month old littermates. Arrowheads indicate the intramuscle fat deposition. Scale bars, 50 um. C. Jhdm2a deficiency results in hyperlipidemia as indicated by the increased levels of serum free fatty acid (FFA), triglyceride (TG) and total cholestrol (TCHO) in Jhdm2a -/- (n=16) compared to Jhdm2 +/+ (n=10) mice. *P<0.05; **P<0.01. D. Growth curve of littermates fed with a high fat diet (HFD) or normal chow. Solid lines, high-fat diet group; dotted lines, normal chow group. BW, body weight. n=4 per group; *P<0.03. Data are mean and s.e.m.
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