Zhang Lab Home

Links to these Articles are available on the IN THE NEWS page. January 2010 Giving cells a fresh start -HHMI News July 2009 Yi Zhang named as Kenan Distinguished Professor January 2009 The Zhang lab identifies a possible drug target -UNC News September 2008 The Zhang lab turns human skin cells into insulin-producing cells. -Science Daily July 2008 Yi Zhang receives the first Battle Distinguished Cancer Reserach Award. -UNC News April 2008 Work from the Zhang Lab is ranked #7 in terms of impact factor. -Sciencewatch.com March 2008 Demystifying Histone Demethylases -The Scientist October 2007 Sperm gene sparks fertility hope. -BBC News Gene defects could be new cause of male infertility. -UNC news August 2006 Study identifies molecular process underlying leukemia. -UNC News June 2006 Novel enzyme offers new look at male hormone regulation; UNC scientists' findings have implications for prostate cancer -UNC News May 2006 -Yamane et.al. Cell. rated a "Must Read" 6.0 by Faculty of 1000. -Huang et.al. Science. rated a "Must Read" 6.0 by Faculty of 1000. -Wang et.al. Mol.Cell. rated a "Must Read" 6.0 by Faculty of 1000. January 2006 Tsukada et.al. Nature. rated an "Exceptional" 9.7 by Faculty of 1000. December 2005 New Discoveries Speak Volumes about how Genes are Silenced. -HHMI News September 2005 Yi Zhang named Howard Hughes Medical Institute investigator. -unchealthcare.org April 2005 Enzyme activity promotes rare form of leukemia, offers potential target for new drugs. -medicalnewstoday.com April 2005 UNC scientists idenitify potential new cancer drug target. November 2004 How Ubiquitin Silences Genes. -genomebiology.com October 2004 Wang et.al. (2004) Nature. rated a "Must Read" 6.7 by Faculty of 1000 September 2004 New molecular link key to cellular proteins involved in cancer progression, other diseases. -medicalnewstoday.com September 2004 Yi Zhang awarded the UNC Hettleman Prize. -unchealthcare.org November 2003 Wang et.al. (2003) Mol Cell. rated a "Must Read" 6.0 by Faculty of 1000. September 2003 UNC researchers identify protein crucial to gene silencing. -scienceblog.com April 2003 Zhang receives prestigious award for cancer research. -unchealthcare.org December 2002 Cao et.al. (2002) Science. rated a "Must Read" 6.0 by Faculty of 1000. October 2002 Study helps explain gene silencing in the developing embryo. -scienceblog.com September 2002 Histone Tails. -Endeavors Magazine December 2001 Protein Discovery tied to DNA master Switch. -sciencedaily.com

A Scheme of the experimental procedure. B, C Time-lapse imaging of CxxC-EGFP (green; left column) and H3.3-mRFP1 (red; middle column) at various pronucleus stages of zygotic development in the absence (b) or presence (c) of siRNA that targets Elp3. Male and female symbols indicate male pronucleus and female pronucleus respectively. PB, polar body. Scale bars, 25um.

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last updated January 11, 2010

from Okada et al. Nature 2010

Knockdown of Elp3 prevents preferential incorporation of the CxxC-EGFP reporter into the paternal pronucleus