Tag: Vicky LeGrys
Improving sweat testing performance: a multi-center collaborative initiative towards earlier diagnosis of infants with CF and positive CF newborn screening tests
We aim to reduce sweat testing quantity not sufficient (QNS) rates in infants who are referred to Cystic Fibrosis Foundation Accredited Care Centers for follow-up testing after a positive newborn screening (NBS) test. It is important to do this now because there is evidence of both high QNS rates at some centers. Additionally a significant percentage of infants diagnosed with CF … Read more
Variation in Sweat Testing Analysis: PTC VISTA
Sweat chloride determinations are used to confirm the diagnosis of CF and also serve as a biomarker for CFTR gene function in clinical trials using protein modulation therapy. Currently, there is uncertainty surrounding the appropriate degree of change in sweat chloride concentrations which reflects a positive response to an investigational drug. Being able to assess a meaningful … Read more