Charlotte Boettiger, Ph.D.
Bowles Center for Alcohol Studies
Department of Psychology
Lab Biomedical Research Imaging Center
The lab’s research is centered around the general goal of determining the neurobiological mechanisms of executive function irregularities associated with addiction. Our experiments fall into three interconnected domains:
Reinforcement-based association learning
Breaking old habits is the essence of recovery from addiction. To help understand how we form and break habits, we study how the brain enables us to learn and replace stimulus-response associations.
Selection bias for immediate rewards
Addiction is associated with a tendency to choose immediate rewards (“Now”) over larger delayed rewards (“Later”). This work focuses on determining the neurobiological mechanisms underlying the tendency to choose Now over Later.
Abnormal attention to addiction-related information
Addiction is also associated with enhanced attention toward addiction -related information. We are characterizing the nature of attention abnormalities associated with addiction, and determining the underlying neural bases of these abnormalities.
In addition, we are interested in dissociating pre-existing risk factors from cognitive consequences of addiction, and in identifying the brain mechanisms of addiction treatment effects.
- Selected as a 2015 National Academy of Sciences Kavli Fellow. More information about the program can be found here: http://www.nasonline.org/programs/kavli-frontiers-of-science/about.html and here: http://www.kavlifoundation.org/kavli-frontiers-science
- Elected as a member of the UNC Faculty Assembly 2015, and was also appointed to the Society for Neuroscience Government & Public Affairs Committee, each for 3 year terms.
- Boettiger Joins CAS Faculty
Neural Systems Underlying Individual Differences in Intertemporal Decision-making. Elton A, Smith CT, Parrish MH, Boettiger CA. J Cogn Neurosci. 2017 Mar;29(3):467-479. doi: 10.1162/jocn_a_01069. PMID:27779911
Orbitofrontal participation in sign- and goal-tracking conditioned responses: Effects of nicotine. Stringfield SJ, Palmatier MI, Boettiger CA, Robinson DL. Neuropharmacology. 2016 Dec 22;116:208-223. doi: 10.1016/j.neuropharm.2016.12.020. PMID:28012948
Addiction History Associates with the Propensity to Form Habits. McKim TH, Bauer DJ, Boettiger CA. J Cogn Neurosci. 2016 Jul;28(7):1024-38. doi: 10.1162/jocn_a_00953. PMID:26967944
Acute phenylalanine/tyrosine depletion of phasic dopamine in the rat brain. Shnitko TA, Taylor SC, Stringfield SJ, Zandy SL, Cofresí RU, Doherty JM, Lynch WB, Boettiger CA, Gonzales RA, Robinson DL. Psychopharmacology (Berl). 2016 Jun;233(11):2045-54. doi: 10.1007/s00213-016-4259-0. PMID:26944052