Charlotte Boettiger, Ph.D.

Assistant Professor
Bowles Center for Alcohol Studies
Department of Psychology
Lab Biomedical Research Imaging Center

Office | 304B Davie Hall, CB#3270
Email | cab@email.unc.edu
Lab Website | Cognition and Addiction Biopsychology
Current Biographical Sketch | pdf

Research Interests

The lab’s research is centered around the general goal of determining the neurobiological mechanisms of executive function irregularities associated with addiction. Our experiments fall into three interconnected domains:

Reinforcement-based association learning
Breaking old habits is the essence of recovery from addiction. To help understand how we form and break habits, we study how the brain enables us to learn and replace stimulus-response associations.

Selection bias for immediate rewards
Addiction is associated with a tendency to choose immediate rewards (“Now”) over larger delayed rewards (“Later”). This work focuses on determining the neurobiological mechanisms underlying the tendency to choose Now over Later.

Abnormal attention to addiction-related information
Addiction is also associated with enhanced attention toward addiction -related information. We are characterizing the nature of attention abnormalities associated with addiction, and determining the underlying neural bases of these abnormalities.

In addition, we are interested in dissociating pre-existing risk factors from cognitive consequences of addiction, and in identifying the brain mechanisms of addiction treatment effects.

News

Recent Publications

Click here for a full list of publications from PubMed

Nicotine-enhanced Pavlovian conditioned approach is resistant to omission of expected outcome. Stringfield SJ, Boettiger CA, Robinson DL. Behav Brain Res. 2018 May 2;343:16-20. doi: 10.1016/j.bbr.2018.01.023. Epub 2018 Feb 3. PMID: 29407412

COMT Val158Met Polymorphism Exerts Sex-Dependent Effects on fMRI Measures of Brain Function. Elton A, Smith CT, Parrish MH, Boettiger CAFront Hum Neurosci. 2017 Dec 6;11:578. doi: 10.3389/fnhum.2017.00578. eCollection 2017. PMID: 29270116

Sex and Adolescent Ethanol Exposure Influence Pavlovian Conditioned Approach. Madayag AC, Stringfield SJ, Reissner KJ, Boettiger CA, Robinson DL. Alcohol Clin Exp Res. 2017 Apr;41(4):846-856. doi: 10.1111/acer.13354. Epub 2017 Mar 13. PMID: 28196273

Orbitofrontal participation in sign- and goal-tracking conditioned responses: Effects of nicotine. Stringfield SJ, Palmatier MI, Boettiger CA, Robinson DL. Neuropharmacology. 2017 Apr;116:208-223. doi: 10.1016/j.neuropharm.2016.12.020. Epub 2016 Dec 22. PMID: 28012948

Neural Systems Underlying Individual Differences in Intertemporal Decision-making. Elton A, Smith CT, Parrish MH, Boettiger CAJ Cogn Neurosci. 2017 Mar;29(3):467-479. doi: 10.1162/jocn_a_01069. Epub 2016 Oct 25. PMID: 27779911