{"id":121,"date":"2011-12-14T19:20:00","date_gmt":"2011-12-15T00:20:00","guid":{"rendered":"https:\/\/med.sites.unc.edu\/alcohol\/faculty-research\/lab-sites\/molecular-neurophysiology-lab\/"},"modified":"2018-04-20T13:44:38","modified_gmt":"2018-04-20T17:44:38","slug":"molecular-neurophysiology-lab","status":"publish","type":"page","link":"https:\/\/www.med.unc.edu\/alcohol\/faculty-research-2\/molecular-neurophysiology-lab\/","title":{"rendered":"Molecular Neurophysiology Lab"},"content":{"rendered":"<p><!-- portlet_header --><\/p>\n<p><!-- portlet_above --><\/p>\n<p><!-- description --><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-914 alignnone\" src=\"https:\/\/www.med.unc.edu\/alcohol\/wp-content\/uploads\/sites\/515\/2018\/04\/IMG_4924-1024x768.jpg\" alt=\"\" width=\"806\" height=\"605\" srcset=\"https:\/\/www.med.unc.edu\/alcohol\/wp-content\/uploads\/sites\/515\/2018\/04\/IMG_4924-1024x768.jpg 1024w, https:\/\/www.med.unc.edu\/alcohol\/wp-content\/uploads\/sites\/515\/2018\/04\/IMG_4924-150x113.jpg 150w, https:\/\/www.med.unc.edu\/alcohol\/wp-content\/uploads\/sites\/515\/2018\/04\/IMG_4924-300x225.jpg 300w, https:\/\/www.med.unc.edu\/alcohol\/wp-content\/uploads\/sites\/515\/2018\/04\/IMG_4924-768x576.jpg 768w, https:\/\/www.med.unc.edu\/alcohol\/wp-content\/uploads\/sites\/515\/2018\/04\/IMG_4924-683x512.jpg 683w\" sizes=\"auto, (max-width: 806px) 100vw, 806px\" \/><\/p>\n<p align=\"left\">Emotional behavior is regulated by a host of chemicals, including neurotransmitters and neuromodulators, acting on specific circuits within the brain. One of the primary focuses of the Kash lab is to understand how chronic drugs of abuse and stress alter neuronal function, focusing on these stress and anti-stress systems in brain circuitry important for anxiety-like behavior. In particular, we are interested in defining alterations in synaptic function, modulation and plasticity using a combination of whole-cell patch-clamp physiology, biochemistry and mouse models.<\/p>\n<h2><b>Research Contributions<\/b><\/h2>\n<ul>\n<li>Chronic alcohol exposure leads to an upregulation of NR2B subunit containing NMDA receptors in the Bed Nucleus of the Stria Terminalis (BNST), a region critical for regulation of stress and anxiety related behavior.<\/li>\n<li>Chronic alcohol exposure leads to a reduction of the effects of alcohol on glutamatergic transmission in the BNST. This alteration in acute alcohol sensitivity could be related to the behavioral tolerance in alcohol-dependent individuals.<\/li>\n<li>Dopamine regulates synaptic transmission and plasticity in the BNST through activation of Corticotropin-releasing factor (CRF) signaling. The BNST receives a novel dopaminergic input from the periacqueductal grey (PAG), suggesting a role for these particular neurons in regulation of BNST function.<\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"<p>Emotional behavior is regulated by a host of chemicals, including neurotransmitters and neuromodulators, acting on specific circuits within the brain. One of the primary focuses of the Kash lab is to understand how chronic drugs of abuse and stress alter neuronal function, focusing on these stress and anti-stress systems in brain circuitry important for anxiety-like &hellip; <a href=\"https:\/\/www.med.unc.edu\/alcohol\/faculty-research-2\/molecular-neurophysiology-lab\/\" aria-label=\"Read more about Molecular Neurophysiology Lab\">Read more<\/a><\/p>\n","protected":false},"author":1362,"featured_media":0,"parent":10,"menu_order":40,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":"","_links_to":"","_links_to_target":""},"class_list":["post-121","page","type-page","status-publish","hentry","odd"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Molecular Neurophysiology Lab | Bowles Center for Alcohol Studies<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.med.unc.edu\/alcohol\/faculty-research-2\/molecular-neurophysiology-lab\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Molecular Neurophysiology Lab | Bowles Center for Alcohol Studies\" \/>\n<meta property=\"og:description\" content=\"Emotional behavior is regulated by a host of chemicals, including neurotransmitters and neuromodulators, acting on specific circuits within the brain. One of the primary focuses of the Kash lab is to understand how chronic drugs of abuse and stress alter neuronal function, focusing on these stress and anti-stress systems in brain circuitry important for anxiety-like &hellip; Read more\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.med.unc.edu\/alcohol\/faculty-research-2\/molecular-neurophysiology-lab\/\" \/>\n<meta property=\"og:site_name\" content=\"Bowles Center for Alcohol Studies\" \/>\n<meta property=\"article:modified_time\" content=\"2018-04-20T17:44:38+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.med.unc.edu\/alcohol\/wp-content\/uploads\/sites\/515\/2018\/04\/IMG_4924-1024x768.jpg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" 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