{"id":127,"date":"2011-12-15T17:55:00","date_gmt":"2011-12-15T22:55:00","guid":{"rendered":"https:\/\/med.sites.unc.edu\/alcohol\/faculty-research\/lab-sites\/pharmacological-treatment-of-alcoholism\/"},"modified":"2017-12-12T15:14:03","modified_gmt":"2017-12-12T20:14:03","slug":"pharmacological-treatment-of-alcoholism","status":"publish","type":"page","link":"https:\/\/www.med.unc.edu\/alcohol\/faculty-research-2\/lab-sites\/pharmacological-treatment-of-alcoholism\/","title":{"rendered":"Pharmacological Treatment of Alcoholism"},"content":{"rendered":"<p><!-- portlet_header --><\/p>\n<p><!-- portlet_above --><\/p>\n<p><!-- description --><\/p>\n<p class=\"lead\">\n<p><span class=\"imageBorder\"><\/p>\n<dl style=\"width:162px;\" class=\"image-right captioned\">\n<dt><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.med.unc.edu\/alcohol\/wp-content\/uploads\/sites\/515\/2017\/12\/image.jpeg\" alt=\"Garbutt\" title=\"Garbutt\" height=\"207\" width=\"162\"\/><\/dt>\n<dd class=\"image-caption\" style=\"width:162px;\">J.C. Garbutt, M.D.<\/dd>\n<\/dl>\n<p><\/span><\/p>\n<h2><b>Primary Areas of Focus<\/b><\/h2>\n<ul>\n<li>Investigation of medications for the treatment of alcoholism including studies of naltrexone, acamprosate, baclofen and combinations of these medications<\/li>\n<li>Investigation of predictors of response to medication, e.g. the sweet-liking phenotype as a predictor of naltrexone response<\/li>\n<li>Investigation of the sweet-liking phenotype as a predictor of risk of alcohol use disorders<\/li>\n<\/ul>\n<h2><b>Key Contributions<\/b><\/h2>\n<ul>\n<li>Lead author for multi-center trial establishing the safety and efficacy of long-acting naltrexone for the treatment of alcoholism.<\/li>\n<li>Co-Investigator for studies demonstrating that the sweet-liking phenotype is a risk factor for alcohol use disorders. Discovered that when combined with other risk factors, such as novelty seeking, the presence of the sweet-liking phenotype greatly increases risk for alcohol-related problems.<\/li>\n<li>Co-Investigator for first placebo-controlled trial of baclofen for the treatment of alcoholism.<\/li>\n<li>Principal Investigator for first placebo-controlled trial of acamprosate for alcoholism in a Family Medicine setting in the United States.<\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"<p>J.C. Garbutt, M.D. Primary Areas of Focus Investigation of medications for the treatment of alcoholism including studies of naltrexone, acamprosate, baclofen and combinations of these medications Investigation of predictors of response to medication, e.g. the sweet-liking phenotype as a predictor of naltrexone response Investigation of the sweet-liking phenotype as a predictor of risk of alcohol &hellip; <a href=\"https:\/\/www.med.unc.edu\/alcohol\/faculty-research-2\/lab-sites\/pharmacological-treatment-of-alcoholism\/\" aria-label=\"Read more about Pharmacological Treatment of Alcoholism\">Read more<\/a><\/p>\n","protected":false},"author":1362,"featured_media":0,"parent":30,"menu_order":18,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":"","_links_to":"","_links_to_target":""},"class_list":["post-127","page","type-page","status-publish","hentry","odd"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Pharmacological Treatment of Alcoholism | Bowles Center for Alcohol Studies<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.med.unc.edu\/alcohol\/faculty-research-2\/lab-sites\/pharmacological-treatment-of-alcoholism\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Pharmacological Treatment of Alcoholism | Bowles Center for Alcohol Studies\" \/>\n<meta property=\"og:description\" content=\"J.C. Garbutt, M.D. Primary Areas of Focus Investigation of medications for the treatment of alcoholism including studies of naltrexone, acamprosate, baclofen and combinations of these medications Investigation of predictors of response to medication, e.g. the sweet-liking phenotype as a predictor of naltrexone response Investigation of the sweet-liking phenotype as a predictor of risk of alcohol &hellip; Read more\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.med.unc.edu\/alcohol\/faculty-research-2\/lab-sites\/pharmacological-treatment-of-alcoholism\/\" \/>\n<meta property=\"og:site_name\" content=\"Bowles Center for Alcohol Studies\" \/>\n<meta property=\"article:modified_time\" content=\"2017-12-12T20:14:03+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.med.unc.edu\/alcohol\/wp-content\/uploads\/sites\/515\/2017\/12\/image.jpeg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" 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