{"id":1365,"date":"2020-01-09T13:44:38","date_gmt":"2020-01-09T18:44:38","guid":{"rendered":"https:\/\/www.med.unc.edu\/alcohol\/?page_id=1365"},"modified":"2025-04-03T15:40:15","modified_gmt":"2025-04-03T19:40:15","slug":"ryan-vetreno-ph-d","status":"publish","type":"page","link":"https:\/\/www.med.unc.edu\/alcohol\/faculty-research-2\/ryan-vetreno-ph-d\/","title":{"rendered":"Ryan Vetreno, Ph.D."},"content":{"rendered":"

 <\/p>\n

\"\"<\/p>\n

Assistant Professor<\/strong><\/p>\n

Bowles Center for Alcohol Studies<\/p>\n

Departments of Psychiatry and Pharmacology<\/p>\n

Office: <\/b>3009 Thurston-Bowles Bldg CB #7178<\/p>\n

Email<\/strong>: rvetreno@email.unc.edu<\/a><\/p>\n

Biographical Sketch: <\/strong>Vetreno Biosketch<\/a><\/p>\n

Research Interests<\/strong><\/h2>\n

My research interests involve investigation of proinflammatory neuroimmune and epigenetic mechanisms in animal models of developmental neurobiology and neurodegeneration, including (1) alcohol pharmacology, (2) adolescent neurodevelopment, (3) cholinergic system and neurocircuitry, and (4) Alzheimer\u2019s disease. A major focus of the laboratory is elucidation of neuroimmune and epigenetic mechanisms underlying adolescent binge alcohol-induced disruption of basal forebrain cholinergic neurocircuitry in adulthood. A second focus of the laboratory is investigation of lasting adolescent binge drinking-induced neuroimmune priming as a novel etiological factor contributing to the onset and progression of basal forebrain neuropathology in Alzheimer\u2019s disease. Our laboratory combines ex vivo and in vivo rodent models of alcohol abuse and Alzheimer\u2019s disease with innovative molecular techniques.<\/p>\n

 <\/p>\n

Publications<\/strong><\/h2>\n

A full list of publications can be found here: https:\/\/www.ncbi.nlm.nih.gov\/myncbi\/ryan.vetreno.1\/bibliography\/public\/<\/a><\/p>\n

 <\/p>\n

    \n
  1. Macht V, Vetreno RP<\/strong>, Elchert N, Fisher R, Crews FT. Indomethacin restores loss of hippocampal neurogenesis and cholinergic innervation, and reduces innate immune expression and reversal learning deficits in adult male and female rats following adolescent ethanol exposure. ACER. 2023 Feb; doi: 10.1111\/acer.15019, PMID<\/u>: 36799290<\/li>\n
  2. Crews FT, Coleman Jr, LG, Macht VA, Vetreno RP<\/strong>. Targeting persistent changes in neuroimmune and epigenetic signaling in adolescent drinking to treat alcohol use disorder in adulthood. Pharmacol Rev. 2023 Mar; 75:380-396, PMID<\/u>: 36781218.<\/li>\n
  3. Qin L, Vetreno RP<\/strong>, Crews FT. NADPH oxidase and endoplasmic reticulum stress is associated with neuronal degeneration in the orbitofrontal cortex of individuals with alcohol use disorder. Addict Biol. 2023 Jan; 28(1):e13262, PMID<\/u>: 36577732.<\/li>\n
  4. Crews FT, Vetreno RP<\/strong>. Cholinergic REST-G9a gene repression through HMGB1-TLR4 neuroimmune signaling regulates basal forebrain cholinergic neuron phenotype. Front Mol Neurosci. 2022 August; 15:992627, eCollection, PMID<\/u>: 36072299.<\/li>\n<\/ol>\n

     <\/p>\n

     <\/p>\n

     <\/p>\n

     <\/p>\n","protected":false},"excerpt":{"rendered":"

      Assistant Professor Bowles Center for Alcohol Studies Departments of Psychiatry and Pharmacology Office: 3009 Thurston-Bowles Bldg CB #7178 Email: rvetreno@email.unc.edu Biographical Sketch: Vetreno Biosketch Research Interests My research interests involve investigation of proinflammatory neuroimmune and epigenetic mechanisms in animal models of developmental neurobiology and neurodegeneration, including (1) alcohol pharmacology, (2) adolescent neurodevelopment, (3) cholinergic … Read more<\/a><\/p>\n","protected":false},"author":63912,"featured_media":0,"parent":10,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":"","_links_to":"","_links_to_target":""},"class_list":["post-1365","page","type-page","status-publish","hentry","odd"],"acf":[],"yoast_head":"\nRyan Vetreno, Ph.D. | Bowles Center for Alcohol Studies<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.med.unc.edu\/alcohol\/faculty-research-2\/ryan-vetreno-ph-d\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Ryan Vetreno, Ph.D. | Bowles Center for Alcohol Studies\" \/>\n<meta property=\"og:description\" content=\"  Assistant Professor Bowles Center for Alcohol Studies Departments of Psychiatry and Pharmacology Office: 3009 Thurston-Bowles Bldg CB #7178 Email: rvetreno@email.unc.edu Biographical Sketch: Vetreno Biosketch Research Interests My research interests involve investigation of proinflammatory neuroimmune and epigenetic mechanisms in animal models of developmental neurobiology and neurodegeneration, including (1) alcohol pharmacology, (2) adolescent neurodevelopment, (3) cholinergic … Read more\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.med.unc.edu\/alcohol\/faculty-research-2\/ryan-vetreno-ph-d\/\" \/>\n<meta property=\"og:site_name\" content=\"Bowles Center for Alcohol Studies\" \/>\n<meta property=\"article:modified_time\" content=\"2025-04-03T19:40:15+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.med.unc.edu\/alcohol\/wp-content\/uploads\/sites\/515\/2020\/01\/Faculty-Pic.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1500\" \/>\n\t<meta property=\"og:image:height\" content=\"2100\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.med.unc.edu\/alcohol\/faculty-research-2\/ryan-vetreno-ph-d\/\",\"url\":\"https:\/\/www.med.unc.edu\/alcohol\/faculty-research-2\/ryan-vetreno-ph-d\/\",\"name\":\"Ryan Vetreno, Ph.D. | Bowles Center for Alcohol Studies\",\"isPartOf\":{\"@id\":\"https:\/\/www.med.unc.edu\/alcohol\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/www.med.unc.edu\/alcohol\/faculty-research-2\/ryan-vetreno-ph-d\/#primaryimage\"},\"image\":{\"@id\":\"https:\/\/www.med.unc.edu\/alcohol\/faculty-research-2\/ryan-vetreno-ph-d\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/www.med.unc.edu\/alcohol\/wp-content\/uploads\/sites\/515\/2020\/01\/Faculty-Pic-214x300.jpg\",\"datePublished\":\"2020-01-09T18:44:38+00:00\",\"dateModified\":\"2025-04-03T19:40:15+00:00\",\"breadcrumb\":{\"@id\":\"https:\/\/www.med.unc.edu\/alcohol\/faculty-research-2\/ryan-vetreno-ph-d\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.med.unc.edu\/alcohol\/faculty-research-2\/ryan-vetreno-ph-d\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/www.med.unc.edu\/alcohol\/faculty-research-2\/ryan-vetreno-ph-d\/#primaryimage\",\"url\":\"https:\/\/www.med.unc.edu\/alcohol\/wp-content\/uploads\/sites\/515\/2020\/01\/Faculty-Pic.jpg\",\"contentUrl\":\"https:\/\/www.med.unc.edu\/alcohol\/wp-content\/uploads\/sites\/515\/2020\/01\/Faculty-Pic.jpg\",\"width\":1500,\"height\":2100},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/www.med.unc.edu\/alcohol\/faculty-research-2\/ryan-vetreno-ph-d\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/www.med.unc.edu\/alcohol\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Faculty\",\"item\":\"https:\/\/www.med.unc.edu\/alcohol\/faculty-research-2\/\"},{\"@type\":\"ListItem\",\"position\":3,\"name\":\"Ryan Vetreno, Ph.D.\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.med.unc.edu\/alcohol\/#website\",\"url\":\"https:\/\/www.med.unc.edu\/alcohol\/\",\"name\":\"Bowles Center for Alcohol Studies\",\"description\":\"\",\"publisher\":{\"@id\":\"https:\/\/www.med.unc.edu\/alcohol\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.med.unc.edu\/alcohol\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/www.med.unc.edu\/alcohol\/#organization\",\"name\":\"Bowles Center for Alcohol Studies\",\"url\":\"https:\/\/www.med.unc.edu\/alcohol\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/www.med.unc.edu\/alcohol\/#\/schema\/logo\/image\/\",\"url\":\"https:\/\/www.med.unc.edu\/alcohol\/wp-content\/uploads\/sites\/515\/2018\/05\/Bowles-Center-for-Alcohol-Studies_logo_rgb_h.png\",\"contentUrl\":\"https:\/\/www.med.unc.edu\/alcohol\/wp-content\/uploads\/sites\/515\/2018\/05\/Bowles-Center-for-Alcohol-Studies_logo_rgb_h.png\",\"width\":1489,\"height\":151,\"caption\":\"Bowles Center for Alcohol Studies\"},\"image\":{\"@id\":\"https:\/\/www.med.unc.edu\/alcohol\/#\/schema\/logo\/image\/\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Ryan Vetreno, Ph.D. | Bowles Center for Alcohol Studies","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.med.unc.edu\/alcohol\/faculty-research-2\/ryan-vetreno-ph-d\/","og_locale":"en_US","og_type":"article","og_title":"Ryan Vetreno, Ph.D. | Bowles Center for Alcohol Studies","og_description":"  Assistant Professor Bowles Center for Alcohol Studies Departments of Psychiatry and Pharmacology Office: 3009 Thurston-Bowles Bldg CB #7178 Email: rvetreno@email.unc.edu Biographical Sketch: Vetreno Biosketch Research Interests My research interests involve investigation of proinflammatory neuroimmune and epigenetic mechanisms in animal models of developmental neurobiology and neurodegeneration, including (1) alcohol pharmacology, (2) adolescent neurodevelopment, (3) cholinergic … Read more","og_url":"https:\/\/www.med.unc.edu\/alcohol\/faculty-research-2\/ryan-vetreno-ph-d\/","og_site_name":"Bowles Center for Alcohol Studies","article_modified_time":"2025-04-03T19:40:15+00:00","og_image":[{"width":1500,"height":2100,"url":"https:\/\/www.med.unc.edu\/alcohol\/wp-content\/uploads\/sites\/515\/2020\/01\/Faculty-Pic.jpg","type":"image\/jpeg"}],"twitter_card":"summary_large_image","twitter_misc":{"Est. reading time":"2 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/www.med.unc.edu\/alcohol\/faculty-research-2\/ryan-vetreno-ph-d\/","url":"https:\/\/www.med.unc.edu\/alcohol\/faculty-research-2\/ryan-vetreno-ph-d\/","name":"Ryan Vetreno, Ph.D. | Bowles Center for Alcohol Studies","isPartOf":{"@id":"https:\/\/www.med.unc.edu\/alcohol\/#website"},"primaryImageOfPage":{"@id":"https:\/\/www.med.unc.edu\/alcohol\/faculty-research-2\/ryan-vetreno-ph-d\/#primaryimage"},"image":{"@id":"https:\/\/www.med.unc.edu\/alcohol\/faculty-research-2\/ryan-vetreno-ph-d\/#primaryimage"},"thumbnailUrl":"https:\/\/www.med.unc.edu\/alcohol\/wp-content\/uploads\/sites\/515\/2020\/01\/Faculty-Pic-214x300.jpg","datePublished":"2020-01-09T18:44:38+00:00","dateModified":"2025-04-03T19:40:15+00:00","breadcrumb":{"@id":"https:\/\/www.med.unc.edu\/alcohol\/faculty-research-2\/ryan-vetreno-ph-d\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.med.unc.edu\/alcohol\/faculty-research-2\/ryan-vetreno-ph-d\/"]}]},{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.med.unc.edu\/alcohol\/faculty-research-2\/ryan-vetreno-ph-d\/#primaryimage","url":"https:\/\/www.med.unc.edu\/alcohol\/wp-content\/uploads\/sites\/515\/2020\/01\/Faculty-Pic.jpg","contentUrl":"https:\/\/www.med.unc.edu\/alcohol\/wp-content\/uploads\/sites\/515\/2020\/01\/Faculty-Pic.jpg","width":1500,"height":2100},{"@type":"BreadcrumbList","@id":"https:\/\/www.med.unc.edu\/alcohol\/faculty-research-2\/ryan-vetreno-ph-d\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/www.med.unc.edu\/alcohol\/"},{"@type":"ListItem","position":2,"name":"Faculty","item":"https:\/\/www.med.unc.edu\/alcohol\/faculty-research-2\/"},{"@type":"ListItem","position":3,"name":"Ryan Vetreno, Ph.D."}]},{"@type":"WebSite","@id":"https:\/\/www.med.unc.edu\/alcohol\/#website","url":"https:\/\/www.med.unc.edu\/alcohol\/","name":"Bowles Center for Alcohol Studies","description":"","publisher":{"@id":"https:\/\/www.med.unc.edu\/alcohol\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.med.unc.edu\/alcohol\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Organization","@id":"https:\/\/www.med.unc.edu\/alcohol\/#organization","name":"Bowles Center for Alcohol Studies","url":"https:\/\/www.med.unc.edu\/alcohol\/","logo":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.med.unc.edu\/alcohol\/#\/schema\/logo\/image\/","url":"https:\/\/www.med.unc.edu\/alcohol\/wp-content\/uploads\/sites\/515\/2018\/05\/Bowles-Center-for-Alcohol-Studies_logo_rgb_h.png","contentUrl":"https:\/\/www.med.unc.edu\/alcohol\/wp-content\/uploads\/sites\/515\/2018\/05\/Bowles-Center-for-Alcohol-Studies_logo_rgb_h.png","width":1489,"height":151,"caption":"Bowles Center for Alcohol Studies"},"image":{"@id":"https:\/\/www.med.unc.edu\/alcohol\/#\/schema\/logo\/image\/"}}]}},"_links_to":[],"_links_to_target":[],"_links":{"self":[{"href":"https:\/\/www.med.unc.edu\/alcohol\/wp-json\/wp\/v2\/pages\/1365","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.med.unc.edu\/alcohol\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.med.unc.edu\/alcohol\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.med.unc.edu\/alcohol\/wp-json\/wp\/v2\/users\/63912"}],"replies":[{"embeddable":true,"href":"https:\/\/www.med.unc.edu\/alcohol\/wp-json\/wp\/v2\/comments?post=1365"}],"version-history":[{"count":1,"href":"https:\/\/www.med.unc.edu\/alcohol\/wp-json\/wp\/v2\/pages\/1365\/revisions"}],"predecessor-version":[{"id":2598,"href":"https:\/\/www.med.unc.edu\/alcohol\/wp-json\/wp\/v2\/pages\/1365\/revisions\/2598"}],"up":[{"embeddable":true,"href":"https:\/\/www.med.unc.edu\/alcohol\/wp-json\/wp\/v2\/pages\/10"}],"wp:attachment":[{"href":"https:\/\/www.med.unc.edu\/alcohol\/wp-json\/wp\/v2\/media?parent=1365"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}