{"id":75,"date":"2011-08-12T16:05:00","date_gmt":"2011-08-12T20:05:00","guid":{"rendered":"https:\/\/med.sites.unc.edu\/alcohol\/faculty-research\/a-leslie-morrow-ph-d\/"},"modified":"2024-01-26T10:14:05","modified_gmt":"2024-01-26T15:14:05","slug":"a-leslie-morrow-ph-d","status":"publish","type":"page","link":"https:\/\/www.med.unc.edu\/alcohol\/faculty-research-2\/a-leslie-morrow-ph-d\/","title":{"rendered":"A. Leslie Morrow, Ph.D."},"content":{"rendered":"

<\/p>\n

<\/p>\n

<\/p>\n

\"A.<\/b><\/p>\n

John Andrews Distinguished Professor<\/b>
\nDepartments of Psychiatry and Pharmacology<\/p>\n

Member<\/b>
\nUNC Neuroscience Center, Curriculum in Neurobiology, and Curriculum in Toxicology<\/p>\n

Office |<\/b> 3027 Thurston-Bowles Bldg, CB #7178
\nEmail |<\/b> morrow@med.unc.edu
\n<\/a>Lab Website |<\/b> Molecular Neuropharmacology<\/a><\/p>\n

Biosketch <\/strong>| Morrow Biosketch<\/a><\/p>\n

Research Interests<\/h2>\n

Sex Specificity of Corticolimbic Circuit Activity and Anxiety-like Behavior After Alcohol Exposure <\/strong><\/p>\n

We are working with Dr. Melissa Herman at UNC to investigate the role of prelimbic prefrontal cortex (PrL) and central amygdala (CeA) regulation of both anxiety and alcohol dependence. We are examining sex-specific differences in PrL and CeA activity and anxiety-like behavior t baseline and following chronic ethanol exposure. In addition, we are examining the impact of allopregnanolone on ethanol-induced dysregulation. \u00a0Funded by NIAAA.<\/p>\n

Mechanisms of Brexanolone (Allopregnanolone) Therapeutics in Post-Partum Depression<\/strong><\/p>\n

Depression is associated with abnormal activation of inflammatory immune signals in the blood and the brain. \u00a0We recently discovered that the endogenous steroid allopregnanolone inhibits these signals and therefore we\u00a0hypothesize\u00a0that this\u00a0mechanism explains the therapeutic effects of the new drug Brexanolone,\u00a0which\u00a0is a proprietary form of allopregnanolone. \u00a0We are working with Drs. Riah Patterson and Samantha Meltzer-Brody to investigate this idea in women with\u00a0postpartum\u00a0depression in hopes of discovering new ways to treat all forms of\u00a0depression.\u00a0 Funded by the Foundation of Hope.<\/p>\n

Clinical Trial to Assess Allopregnanolone Infusion during Alcohol Detoxification <\/strong>for Recovery from Withdrawal and Prevention of Relapse in Alcohol Use Disorder<\/strong><\/p>\n

We are working with Drs. David Goldman and Nancy Diaz-Granados and their team at NIAAA to investigate whether Brexanolone infusion will be an effective treatment for AUD detoxification by relieving ethanol withdrawal symptoms and preventing relapse through its anti-inflammatory actions in patient blood cells.\u00a0 Funded by NIAAA and Donations to UNC.<\/p>\n

Allopregnanolone and THDOC Enhancement of Anti-Inflammatory Signals<\/strong><\/p>\n

We recently discovered that endogenous neuroactive steroids enhance the production of the ANTI-INFLAMMATORY mediators FRACKTALKINE and IL-10 in monocytes\/macrophages and the brain. We are working to identify the pathways involved, the potency of various endogenous steroids, and the mechanism(s) of action. These studies will define a NOVEL mechanism of endogenous neurosteroid action on neuroimmune signaling with potential to alleviate inflammatory signaling associated with many neuropsychiatric diseases. Funded by Sage Therapeutics.<\/p>\n

Biomarkers of Systemic Inflammation in Alcohol Use Disorder<\/strong><\/p>\n

We are working with Dr. Christian Hendershot at UNC to develop a biomarker assay of innate inflammation in blood cells of non-treatment seeking heavy drinkers who meet AUD criteria compared to light social drinkers and determine if allopregnanolone can inhibit the inflammatory signals or sensitivity to inflammatory activators in blood from these subjects.\u00a0 We will further determine the concentration of allopregnanolone necessary to block these signals in blood studied ex vivo. \u00a0Funded by the Foundation of Hope.<\/p>\n

 <\/p>\n

Recent Publications<\/h2>\n

Click here for a full list of publications from PubMed<\/a><\/span><\/span><\/p>\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

John Andrews Distinguished Professor Departments of Psychiatry and Pharmacology Member UNC Neuroscience Center, Curriculum in Neurobiology, and Curriculum in Toxicology Office | 3027 Thurston-Bowles Bldg, CB #7178 Email | morrow@med.unc.edu Lab Website | Molecular Neuropharmacology Biosketch | Morrow Biosketch Research Interests Sex Specificity of Corticolimbic Circuit Activity and Anxiety-like Behavior After Alcohol Exposure We are … Read more<\/a><\/p>\n","protected":false},"author":1362,"featured_media":0,"parent":10,"menu_order":12,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":"","_links_to":"","_links_to_target":""},"class_list":["post-75","page","type-page","status-publish","hentry","odd"],"acf":[],"yoast_head":"\nA. Leslie Morrow, Ph.D. | Bowles Center for Alcohol Studies<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.med.unc.edu\/alcohol\/faculty-research-2\/a-leslie-morrow-ph-d\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"A. Leslie Morrow, Ph.D. | Bowles Center for Alcohol Studies\" \/>\n<meta property=\"og:description\" content=\"John Andrews Distinguished Professor Departments of Psychiatry and Pharmacology Member UNC Neuroscience Center, Curriculum in Neurobiology, and Curriculum in Toxicology Office | 3027 Thurston-Bowles Bldg, CB #7178 Email | morrow@med.unc.edu Lab Website | Molecular Neuropharmacology Biosketch | Morrow Biosketch Research Interests Sex Specificity of Corticolimbic Circuit Activity and Anxiety-like Behavior After Alcohol Exposure We are … Read more\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.med.unc.edu\/alcohol\/faculty-research-2\/a-leslie-morrow-ph-d\/\" \/>\n<meta property=\"og:site_name\" content=\"Bowles Center for Alcohol Studies\" \/>\n<meta property=\"article:modified_time\" content=\"2024-01-26T15:14:05+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.med.unc.edu\/alcohol\/wp-content\/uploads\/sites\/515\/2017\/12\/ALM_02_002.jpg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"3 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.med.unc.edu\/alcohol\/faculty-research-2\/a-leslie-morrow-ph-d\/\",\"url\":\"https:\/\/www.med.unc.edu\/alcohol\/faculty-research-2\/a-leslie-morrow-ph-d\/\",\"name\":\"A. Leslie Morrow, Ph.D. | Bowles Center for Alcohol Studies\",\"isPartOf\":{\"@id\":\"https:\/\/www.med.unc.edu\/alcohol\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/www.med.unc.edu\/alcohol\/faculty-research-2\/a-leslie-morrow-ph-d\/#primaryimage\"},\"image\":{\"@id\":\"https:\/\/www.med.unc.edu\/alcohol\/faculty-research-2\/a-leslie-morrow-ph-d\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/www.med.unc.edu\/alcohol\/wp-content\/uploads\/sites\/515\/2017\/12\/ALM_02_002.jpg\",\"datePublished\":\"2011-08-12T20:05:00+00:00\",\"dateModified\":\"2024-01-26T15:14:05+00:00\",\"breadcrumb\":{\"@id\":\"https:\/\/www.med.unc.edu\/alcohol\/faculty-research-2\/a-leslie-morrow-ph-d\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.med.unc.edu\/alcohol\/faculty-research-2\/a-leslie-morrow-ph-d\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/www.med.unc.edu\/alcohol\/faculty-research-2\/a-leslie-morrow-ph-d\/#primaryimage\",\"url\":\"https:\/\/www.med.unc.edu\/alcohol\/wp-content\/uploads\/sites\/515\/2017\/12\/ALM_02_002.jpg\",\"contentUrl\":\"https:\/\/www.med.unc.edu\/alcohol\/wp-content\/uploads\/sites\/515\/2017\/12\/ALM_02_002.jpg\",\"width\":175,\"height\":219},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/www.med.unc.edu\/alcohol\/faculty-research-2\/a-leslie-morrow-ph-d\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/www.med.unc.edu\/alcohol\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Faculty\",\"item\":\"https:\/\/www.med.unc.edu\/alcohol\/faculty-research-2\/\"},{\"@type\":\"ListItem\",\"position\":3,\"name\":\"A. Leslie Morrow, Ph.D.\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.med.unc.edu\/alcohol\/#website\",\"url\":\"https:\/\/www.med.unc.edu\/alcohol\/\",\"name\":\"Bowles Center for Alcohol Studies\",\"description\":\"\",\"publisher\":{\"@id\":\"https:\/\/www.med.unc.edu\/alcohol\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.med.unc.edu\/alcohol\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/www.med.unc.edu\/alcohol\/#organization\",\"name\":\"Bowles Center for Alcohol Studies\",\"url\":\"https:\/\/www.med.unc.edu\/alcohol\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/www.med.unc.edu\/alcohol\/#\/schema\/logo\/image\/\",\"url\":\"https:\/\/www.med.unc.edu\/alcohol\/wp-content\/uploads\/sites\/515\/2018\/05\/Bowles-Center-for-Alcohol-Studies_logo_rgb_h.png\",\"contentUrl\":\"https:\/\/www.med.unc.edu\/alcohol\/wp-content\/uploads\/sites\/515\/2018\/05\/Bowles-Center-for-Alcohol-Studies_logo_rgb_h.png\",\"width\":1489,\"height\":151,\"caption\":\"Bowles Center for Alcohol Studies\"},\"image\":{\"@id\":\"https:\/\/www.med.unc.edu\/alcohol\/#\/schema\/logo\/image\/\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"A. Leslie Morrow, Ph.D. | Bowles Center for Alcohol Studies","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.med.unc.edu\/alcohol\/faculty-research-2\/a-leslie-morrow-ph-d\/","og_locale":"en_US","og_type":"article","og_title":"A. Leslie Morrow, Ph.D. | Bowles Center for Alcohol Studies","og_description":"John Andrews Distinguished Professor Departments of Psychiatry and Pharmacology Member UNC Neuroscience Center, Curriculum in Neurobiology, and Curriculum in Toxicology Office | 3027 Thurston-Bowles Bldg, CB #7178 Email | morrow@med.unc.edu Lab Website | Molecular Neuropharmacology Biosketch | Morrow Biosketch Research Interests Sex Specificity of Corticolimbic Circuit Activity and Anxiety-like Behavior After Alcohol Exposure We are … Read more","og_url":"https:\/\/www.med.unc.edu\/alcohol\/faculty-research-2\/a-leslie-morrow-ph-d\/","og_site_name":"Bowles Center for Alcohol Studies","article_modified_time":"2024-01-26T15:14:05+00:00","og_image":[{"url":"https:\/\/www.med.unc.edu\/alcohol\/wp-content\/uploads\/sites\/515\/2017\/12\/ALM_02_002.jpg","type":"","width":"","height":""}],"twitter_card":"summary_large_image","twitter_misc":{"Est. reading time":"3 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/www.med.unc.edu\/alcohol\/faculty-research-2\/a-leslie-morrow-ph-d\/","url":"https:\/\/www.med.unc.edu\/alcohol\/faculty-research-2\/a-leslie-morrow-ph-d\/","name":"A. Leslie Morrow, Ph.D. | Bowles Center for Alcohol Studies","isPartOf":{"@id":"https:\/\/www.med.unc.edu\/alcohol\/#website"},"primaryImageOfPage":{"@id":"https:\/\/www.med.unc.edu\/alcohol\/faculty-research-2\/a-leslie-morrow-ph-d\/#primaryimage"},"image":{"@id":"https:\/\/www.med.unc.edu\/alcohol\/faculty-research-2\/a-leslie-morrow-ph-d\/#primaryimage"},"thumbnailUrl":"https:\/\/www.med.unc.edu\/alcohol\/wp-content\/uploads\/sites\/515\/2017\/12\/ALM_02_002.jpg","datePublished":"2011-08-12T20:05:00+00:00","dateModified":"2024-01-26T15:14:05+00:00","breadcrumb":{"@id":"https:\/\/www.med.unc.edu\/alcohol\/faculty-research-2\/a-leslie-morrow-ph-d\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.med.unc.edu\/alcohol\/faculty-research-2\/a-leslie-morrow-ph-d\/"]}]},{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.med.unc.edu\/alcohol\/faculty-research-2\/a-leslie-morrow-ph-d\/#primaryimage","url":"https:\/\/www.med.unc.edu\/alcohol\/wp-content\/uploads\/sites\/515\/2017\/12\/ALM_02_002.jpg","contentUrl":"https:\/\/www.med.unc.edu\/alcohol\/wp-content\/uploads\/sites\/515\/2017\/12\/ALM_02_002.jpg","width":175,"height":219},{"@type":"BreadcrumbList","@id":"https:\/\/www.med.unc.edu\/alcohol\/faculty-research-2\/a-leslie-morrow-ph-d\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/www.med.unc.edu\/alcohol\/"},{"@type":"ListItem","position":2,"name":"Faculty","item":"https:\/\/www.med.unc.edu\/alcohol\/faculty-research-2\/"},{"@type":"ListItem","position":3,"name":"A. Leslie Morrow, Ph.D."}]},{"@type":"WebSite","@id":"https:\/\/www.med.unc.edu\/alcohol\/#website","url":"https:\/\/www.med.unc.edu\/alcohol\/","name":"Bowles Center for Alcohol Studies","description":"","publisher":{"@id":"https:\/\/www.med.unc.edu\/alcohol\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.med.unc.edu\/alcohol\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Organization","@id":"https:\/\/www.med.unc.edu\/alcohol\/#organization","name":"Bowles Center for Alcohol Studies","url":"https:\/\/www.med.unc.edu\/alcohol\/","logo":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.med.unc.edu\/alcohol\/#\/schema\/logo\/image\/","url":"https:\/\/www.med.unc.edu\/alcohol\/wp-content\/uploads\/sites\/515\/2018\/05\/Bowles-Center-for-Alcohol-Studies_logo_rgb_h.png","contentUrl":"https:\/\/www.med.unc.edu\/alcohol\/wp-content\/uploads\/sites\/515\/2018\/05\/Bowles-Center-for-Alcohol-Studies_logo_rgb_h.png","width":1489,"height":151,"caption":"Bowles Center for Alcohol Studies"},"image":{"@id":"https:\/\/www.med.unc.edu\/alcohol\/#\/schema\/logo\/image\/"}}]}},"_links_to":[],"_links_to_target":[],"_links":{"self":[{"href":"https:\/\/www.med.unc.edu\/alcohol\/wp-json\/wp\/v2\/pages\/75","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.med.unc.edu\/alcohol\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.med.unc.edu\/alcohol\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.med.unc.edu\/alcohol\/wp-json\/wp\/v2\/users\/1362"}],"replies":[{"embeddable":true,"href":"https:\/\/www.med.unc.edu\/alcohol\/wp-json\/wp\/v2\/comments?post=75"}],"version-history":[{"count":0,"href":"https:\/\/www.med.unc.edu\/alcohol\/wp-json\/wp\/v2\/pages\/75\/revisions"}],"up":[{"embeddable":true,"href":"https:\/\/www.med.unc.edu\/alcohol\/wp-json\/wp\/v2\/pages\/10"}],"wp:attachment":[{"href":"https:\/\/www.med.unc.edu\/alcohol\/wp-json\/wp\/v2\/media?parent=75"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}