{"id":79,"date":"2011-08-17T19:40:00","date_gmt":"2011-08-17T23:40:00","guid":{"rendered":"https:\/\/med.sites.unc.edu\/alcohol\/faculty-research\/c-j-malanga-m-d-ph-d\/"},"modified":"2017-12-11T16:40:51","modified_gmt":"2017-12-11T21:40:51","slug":"c-j-malanga-m-d-ph-d","status":"publish","type":"page","link":"https:\/\/www.med.unc.edu\/alcohol\/faculty-research-2\/c-j-malanga-m-d-ph-d\/","title":{"rendered":"C.J. Malanga, M.D., Ph.D."},"content":{"rendered":"<p><!-- portlet_header --><\/p>\n<p><!-- portlet_above --><\/p>\n<p><!-- description --><\/p>\n<p class=\"lead\">\n<p><b>Associate Professor<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.med.unc.edu\/alcohol\/wp-content\/uploads\/sites\/515\/2017\/12\/malanga.jpeg\" title=\"Malanga\" height=\"189\" width=\"140\" alt=\"Malanga\" class=\"image-left\"\/><\/b><br \/>Department of Neurology<br \/>Bowles Center for Alcohol Studies<\/p>\n<p><b>Office |<\/b> Neuroscience Research Bldg (NSRB) 6109-C<br \/><b>Email |<\/b> <a class=\"mail-link\" href=\"mailto:malangacj@neurology.unc.edu\">malangacj@neurology.unc.edu<\/a><br \/><b>Lab Website |<\/b><a class=\"external-link\" href=\"http:\/\/malangalab.web.unc.edu\"> Developmental Neuropharmacology<\/a><\/p>\n<\/p>\n<h2>Research Interests<\/h2>\n<ul>\n<li>Physiology and pharmacology of the basal ganglia<\/li>\n<li>Neurobiology of motivation and reward<\/li>\n<li>Effects of early exposure to drugs of abuse on brain and behavioral development<\/li>\n<li>Cellular electrophysiology<\/li>\n<li>Behavioral and developmental neuroscience<\/li>\n<li>Drug abuse neurobiology<\/li>\n<\/ul>\n<h2>Clinical Interests<\/h2>\n<ul>\n<li>Movement disorders in children<\/li>\n<li>Consequences of prenatal exposure to drugs of abuse<\/li>\n<\/ul>\n<h2>Recent Publications<\/h2>\n<p>Pathway-specific dopaminergic deficits in a mouse model of Angleman syndrome. Riday, TT., Dankoski, E., Krouse, MC., Fish, EW., Walsh, PL., Han, JE., Hodge, CW., Wightman, RM., Philpot, BD. and Malanga, CJ.  Journal of Clinical Investigation 2012 (In Press).<\/p>\n<p> <a class=\"external-link\" href=\"http:\/\/www.ncbi.nlm.nih.gov.libproxy.lib.unc.edu\/pubmed?term=robinson%3B%20comparison%20to%20mice%3B%2076-81\">Mephedrone (4-methylmethcathinone) and intracranial self-stimulation in C57BL\/6J mice: comparison to cocaine.<\/a> Robinson, JE., Agoglia, AE., Fish, EW., Krouse, MC. and Malanga, CJ.  Behavioral Brain Research 2012 234(1):76-81.<\/p>\n<p><a class=\"external-link\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22197517\">The rewarding and locomotor-sensitizing effects of repeated cocaine administration are distinct and separable in mice.<\/a> Riday, TT., Kosofsky, BE., and Malanga, CJ. Neuropharmacology 62(4):1858-66.<\/p>\n<p><a class=\"external-link\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22133306\">Orexin-1 receptor antagonism does not reduce the rewarding potency of cocaine in Swiss-Webster mice.<\/a> Riday, TT., Fish, EW., Robinson, JE., Jarrett, TM., McGuigan MM. and Malanga, CJ. Brain Research 2012 Jan 11;1431:53-61. <\/p>\n<p><a class=\"external-link\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/21983918\" target=\"_blank\">Intracranial self-stimulation in FAST and SLOW mice: effects of alcohol and cocaine.<\/a> Fish, EW., Robinson, JE., Krouse, MC., Hodge, CW., Reed, C., Phillips, TJ. and Malanga, CJ.  Psychopharmacology 2012 220(4):719-30.<\/p>\n<p><a class=\"external-link\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/21909635\">Potentiation of brain stimulation reward by morphine: effects of neurokinin-1 receptor antagonism.<\/a> Robinson, JE., Fish, EW., Krouse, MC., Thorsell, A., Heilig, M. and Malanga, CJ., Psychopharmacology 2012 220(1):215-24<br \/><a class=\"external-link\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/19860803\" target=\"_blank\"\/><\/p>\n<p class=\"style1\">\n<ol\/>\n","protected":false},"excerpt":{"rendered":"<p>Associate ProfessorDepartment of NeurologyBowles Center for Alcohol Studies Office | Neuroscience Research Bldg (NSRB) 6109-CEmail | malangacj@neurology.unc.eduLab Website | Developmental Neuropharmacology Research Interests Physiology and pharmacology of the basal ganglia Neurobiology of motivation and reward Effects of early exposure to drugs of abuse on brain and behavioral development Cellular electrophysiology Behavioral and developmental neuroscience Drug &hellip; <a href=\"https:\/\/www.med.unc.edu\/alcohol\/faculty-research-2\/c-j-malanga-m-d-ph-d\/\" aria-label=\"Read more about C.J. Malanga, M.D., Ph.D.\">Read more<\/a><\/p>\n","protected":false},"author":1362,"featured_media":0,"parent":10,"menu_order":20,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":"","_links_to":"","_links_to_target":""},"class_list":["post-79","page","type-page","status-publish","hentry","odd"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>C.J. Malanga, M.D., Ph.D. | Bowles Center for Alcohol Studies<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.med.unc.edu\/alcohol\/faculty-research-2\/c-j-malanga-m-d-ph-d\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"C.J. 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