{"id":927,"date":"2018-04-20T10:16:41","date_gmt":"2018-04-20T14:16:41","guid":{"rendered":"https:\/\/www.med.unc.edu\/alcohol\/?page_id=927"},"modified":"2025-01-31T14:17:12","modified_gmt":"2025-01-31T19:17:12","slug":"lcoleman","status":"publish","type":"page","link":"https:\/\/www.med.unc.edu\/alcohol\/lcoleman\/","title":{"rendered":"Leon Coleman, M.D., Ph.D."},"content":{"rendered":"

 <\/p>\n\n\n\n
\"\"<\/td>\n\n

Assistant Professor<\/strong><\/p>\n

Bowles Center for Alcohol Studies<\/p>\n

Department of Pharmacology<\/p>\n

Office:<\/strong> 1007C Thurston Bowles Bldg CB#7178<\/p>\n

Email:<\/strong>\u00a0leon_coleman@med.unc.edu<\/a><\/p>\n

Biographical Sketch:<\/strong> Coleman Biosketch<\/a><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

 <\/p>\n

Research Interests<\/p>\n

The overriding goal of Dr. Coleman\u2019s work is to identify novel treatments for immune related conditions such as Alzheimer\u2019s disease, addiction, cancer and trauma.\u00a0 Studies in addiction focus on alcohol use disorder and cocaine use disorder. Further description of these projects include:<\/p>\n

Prevention and treatment of Alzheimer\u2019s disease (AD):<\/u> The majority of AD cases are sporadic (i.e., no clear etiology); however several modifiable risk factors have been identified. The goal of this project is to identify cellular and molecular mechanisms underlying the increased risk for AD caused by modifiable risk factors such as heavy alcohol use and obesity.<\/p>\n

Treatment of symptomatology of alcohol use disorder (AUD) and cocaine use disorder (CUD)<\/u>: Proinflammatory signaling is induced in the pathology of several addictions such as AUD and CUD. This project examines the overall hypothesis that innate immune signaling contributes to key features of AUD and CUD such as stress, neuronal damage, and substance use.\u00a0 Specific immune pathways are investigated in models of addiction.<\/p>\n

Improving efficacy of cancer immunotherapy:<\/u> Response to anti-PD1 immunotherapy is low for most cancers. However, determinants of response of often unknown. This project studies the impact that common exposures have on anti-PD1 efficacy such as alcohol use and stress.<\/p>\n

Identifying novel immune regulators in settings of severe trauma:<\/u> Poor outcomes in settings of severe trauma such as large burn injury and radiation injury are often related to immune dysfunction. However, therapeutic targets to normalize immune dysfunction after trauma are lacking. This project studies the impact of novel immune regulators such as extracellular vesicles in the pathology of trauma.<\/p>\n

Selected Recent Publications<\/p>\n

Click here for a full list of publications from PubMed<\/a><\/p>\n

    \n
  1. Barnett A, David E, Rohlman A, Nikolova VD, Moy SS, Vetreno RP, Coleman LG Jr.\u00a0Adolescent Binge Alcohol Enhances Early Alzheimer’s Disease Pathology in Adulthood Through Proinflammatory Neuroimmune Activation.\u00a0Front Pharmacol.\u00a02022;13:884170.\u00a0doi: 10.3389\/fphar.2022.884170.\u00a0eCollection 2022.\u00a0PubMed PMID: 35559229; PubMed Central PMCID: PMC9086457.<\/li>\n
  2. Zou J, Walter TJ, Barnett A, Rohlman A, Crews FT, Coleman LG Jr. Ethanol Induces Secretion of Proinflammatory Extracellular Vesicles That Inhibit Adult Hippocampal Neurogenesis Through G9a\/GLP-Epigenetic Signaling. Front Immunol. 2022;13:866073. doi: 10.3389\/fimmu.2022.866073. eCollection 2022. PubMed PMID: 35634322; PubMed Central PMCID: PMC9136051.<\/li>\n
  3. Qin L, Zou J, Barnett A, Vetreno RP, Crews FT, Coleman LG Jr.\u00a0TRAIL Mediates Neuronal Death in AUD: A Link between Neuroinflammation and Neurodegeneration.\u00a0<\/a>Int J Mol Sci. 2021 Mar 4;22(5). doi: 10.3390\/ijms22052547. PubMed PMID: 33806288; PubMed Central PMCID: PMC7961445.<\/li>\n
  4. Willis ML, Mahung C, Wallet SM, Barnett A, Cairns BA, Coleman LG Jr, Maile R. Plasma extracellular vesicles released after severe burn injury modulate macrophage phenotype and function. J Leukoc Biol. 2022 Jan;111(1):33-49. doi: 10.1002\/JLB.3MIA0321-150RR. Epub 2021 Aug 3. PubMed PMID: 34342045; PubMed Central PMCID: PMC8716518.<\/li>\n<\/ol>\n

     <\/p>\n","protected":false},"excerpt":{"rendered":"

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