{"id":96,"date":"2011-09-16T19:50:00","date_gmt":"2011-09-16T23:50:00","guid":{"rendered":"https:\/\/med.sites.unc.edu\/alcohol\/faculty-research\/james-c-garbutt-m-d\/"},"modified":"2018-03-22T14:14:13","modified_gmt":"2018-03-22T18:14:13","slug":"james-c-garbutt-m-d","status":"publish","type":"page","link":"https:\/\/www.med.unc.edu\/alcohol\/faculty-research-2\/james-c-garbutt-m-d\/","title":{"rendered":"James C. Garbutt, M.D."},"content":{"rendered":"

<\/p>\n

<\/p>\n

<\/p>\n

Professor \"J.C.<\/b>
\nUNC Department of Psychiatry<\/p>\n

Office |<\/b> CB #7160
\nEmail |<\/b> jc_garbutt@med.unc.edu<\/a>
\nResearch Website | Addiction and Alcohol Clinical Trials <\/a> <\/b><\/p>\n

Research Interests<\/h2>\n

My research interests involve several directions related to the biology of alcoholism and the development of new psychopharmacological strategies to treat alcoholism.<\/p>\n

Relationship between Sweet Preference and Alcoholism
\nIn collaboration with Dr. Alexey Kampov of the Center for Alcohol Studies we have extended an observation made in animals that preference for alcohol and preference for sweets are strongly correlated with one another by studying sweet preference in alcoholic men. Humans can be subdivided into sweet likers and sweet dislikers based on subjective responses to increasing concentrations of sugars. We have shown that 65% of abstinent male alcoholics without significant liver or pancreatic disease can be classified as sweet likers compared to 16% of nonalcoholic, similarly aged males. We are currently investigating the replicability of this finding, associated clinical variables and possible confounders such as altered taste or smell perception.<\/p>\n

Baclofen for the Treatment of Alcohol Dependence
\nWe are currently studying the efficacy and tolerability of baclofen, 30 mg\/d, compared to placebo in men and women with alcohol dependence. Baclofen is a GABA-B agonist that has shown promise in animal models of heavy alcohol use and in one small human placebo-controlled trial where it reduced alcohol consumption and enhanced abstinence. We are also interested in developing a pilot study of combining baclofen with naltrexone for alcoholism.<\/p>\n

Visit the AACT website <\/a> for additional information.<\/p>\n

Recent Publications<\/h2>\n

Click here for a list of publications from PubMed<\/span><\/a><\/span><\/p>\n

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Implementation of a Process for Initiating Naltrexone in Patients Hospitalized for Alcohol Detoxification or Withdrawal.<\/a>\u00a0Stephens JR, Moore C, Stepanek KV, Garbutt JC<\/strong>, Starke B, Liles A, Jonas DE.\u00a0J Hosp Med<\/span>. 2018 Jan 24:E1-E8. doi: 10.12788\/jhm.2900. PMID: 29364992<\/a><\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/form>\n<\/div>\n<\/div>\n

Association of the Sweet-Liking Phenotype and Craving for Alcohol With the Response to Naltrexone Treatment in Alcohol Dependence: A Randomized Clinical Trial.<\/a> Garbutt JC<\/strong>, Kampov-Polevoy AB, Kalka-Juhl LS, Gallop RJ. JAMA Psychiatry<\/span>. 2016 Oct 1;73(10):1056-1063. doi: 10.1001\/jamapsychiatry.2016.2157. PMID:27627782<\/a><\/p>\n

Alcohol Use Disorder Treatment: The Association of Pretreatment Use and the Role of Drinking Goal.<\/a> Berger L, Brondino M, Fisher M, Gwyther R, Garbutt JC.<\/strong> J Am Board Fam Med<\/span>. 2016 Jan-Feb;29(1):37-49. doi: 10.3122\/jabfm.2016.01.150143. PMID:26769876<\/a><\/p>\n

Genetic polymorphisms and response to medications for alcohol use disorders: a systematic review and meta-analysis.<\/a> Jonas DE, Amick HR, Feltner C, Wines R, Shanahan E, Rowe CJ, Garbutt JC<\/strong>. Pharmacogenomics<\/span>. 2014 Sep;15(13):1687-700. doi: 10.2217\/pgs.14.121. Review. PMID:25410894<\/a><\/p>\n

Medications for alcohol use disorders–reply.<\/a> Jonas DE, Feltner C, Garbutt JC<\/strong>. JAMA<\/span>. 2014 Oct 1;312(13):1351. doi: 10.1001\/jama.2014.10170. No abstract available. PMID:25268447<\/a><\/p>\n

 <\/p>\n

<\/div>\n

\u00a0<\/span><\/span><\/p>\n","protected":false},"excerpt":{"rendered":"

Professor UNC Department of Psychiatry Office | CB #7160 Email | jc_garbutt@med.unc.edu Research Website | Addiction and Alcohol Clinical Trials Research Interests My research interests involve several directions related to the biology of alcoholism and the development of new psychopharmacological strategies to treat alcoholism. Relationship between Sweet Preference and Alcoholism In collaboration with Dr. Alexey … Read more<\/a><\/p>\n","protected":false},"author":1362,"featured_media":0,"parent":10,"menu_order":28,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":"","_links_to":"","_links_to_target":""},"class_list":["post-96","page","type-page","status-publish","hentry","odd"],"acf":[],"yoast_head":"\nJames C. 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