{"id":1344,"date":"2019-11-13T13:41:16","date_gmt":"2019-11-13T18:41:16","guid":{"rendered":"https:\/\/www.med.unc.edu\/alcohol\/?p=1344"},"modified":"2019-11-13T13:41:16","modified_gmt":"2019-11-13T18:41:16","slug":"new-evidence-from-the-hodge-lab-shows-that-moderate-alcohol-drinking-exacerbates-brain-and-behavioral-pathologies-associated-with-alzheimers-disease","status":"publish","type":"post","link":"https:\/\/www.med.unc.edu\/alcohol\/new-evidence-from-the-hodge-lab-shows-that-moderate-alcohol-drinking-exacerbates-brain-and-behavioral-pathologies-associated-with-alzheimers-disease\/","title":{"rendered":"New evidence from the Hodge Lab shows that moderate alcohol drinking exacerbates brain and behavioral pathologies associated with Alzheimer\u2019s disease"},"content":{"rendered":"<p><strong>New evidence from the Hodge Lab shows that moderate alcohol drinking exacerbates brain and behavioral pathologies associated with Alzheimer\u2019s disease<\/strong><\/p>\n<p>&nbsp;<\/p>\n<p>The consequences of non-dependent alcohol drinking on health and well-being in older adults is not fully understood. Evidence suggests that alcohol abuse during mid-life exacerbates age-related cognitive decline and may increase the risk of developing dementia after age 65. Alzheimer&#8217;s disease (AD) is a major cause of dementia in older individuals, but it is unclear if alcohol drinking can target the same molecular mechanisms in the brain that underlie AD neural pathology like amyloid plaques and tau tangles. Using the well-validated 3xTg-AD transgenic mice that model Alzheimer\u2019s disease (\u201chumanized\u201d mice express human tau, presenilin, and amyloid precursor transgenes), the Hodge lab has found new evidence that moderate alcohol drinking increases the onset and progression of neural pathology and cognitive decline associated with AD. This study is published in the International Review of Neurobiology and is available at the following link: <a href=\"https:\/\/authors.elsevier.com\/b\/1a38xH06wnw2h\">https:\/\/authors.elsevier.com\/b\/1a38xH06wnw2h<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>New evidence from the Hodge Lab shows that moderate alcohol drinking exacerbates brain and behavioral pathologies associated with Alzheimer\u2019s disease &nbsp; The consequences of non-dependent alcohol drinking on health and well-being in older adults is not fully understood. Evidence suggests that alcohol abuse during mid-life exacerbates age-related cognitive decline and may increase the risk of &hellip; <a href=\"https:\/\/www.med.unc.edu\/alcohol\/new-evidence-from-the-hodge-lab-shows-that-moderate-alcohol-drinking-exacerbates-brain-and-behavioral-pathologies-associated-with-alzheimers-disease\/\" aria-label=\"Read more about New evidence from the Hodge Lab shows that moderate alcohol drinking exacerbates brain and behavioral pathologies associated with Alzheimer\u2019s disease\">Read more<\/a><\/p>\n","protected":false},"author":63912,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":"","_links_to":"","_links_to_target":""},"categories":[1],"tags":[],"class_list":["post-1344","post","type-post","status-publish","format-standard","hentry","category-news","odd"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>New evidence from the Hodge Lab shows that moderate alcohol drinking exacerbates brain and behavioral pathologies associated with Alzheimer\u2019s disease | Bowles Center for Alcohol Studies<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.med.unc.edu\/alcohol\/new-evidence-from-the-hodge-lab-shows-that-moderate-alcohol-drinking-exacerbates-brain-and-behavioral-pathologies-associated-with-alzheimers-disease\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"New evidence from the Hodge Lab shows that moderate alcohol drinking exacerbates brain and behavioral pathologies associated with Alzheimer\u2019s disease | Bowles Center for Alcohol Studies\" \/>\n<meta property=\"og:description\" content=\"New evidence from the Hodge Lab shows that moderate alcohol drinking exacerbates brain and behavioral pathologies associated with Alzheimer\u2019s disease &nbsp; The consequences of non-dependent alcohol drinking on health and well-being in older adults is not fully understood. Evidence suggests that alcohol abuse during mid-life exacerbates age-related cognitive decline and may increase the risk of &hellip; Read more\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.med.unc.edu\/alcohol\/new-evidence-from-the-hodge-lab-shows-that-moderate-alcohol-drinking-exacerbates-brain-and-behavioral-pathologies-associated-with-alzheimers-disease\/\" \/>\n<meta property=\"og:site_name\" content=\"Bowles Center for Alcohol Studies\" \/>\n<meta property=\"article:published_time\" content=\"2019-11-13T18:41:16+00:00\" \/>\n<meta name=\"author\" content=\"Brooke Mansfield\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Brooke Mansfield\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/www.med.unc.edu\/alcohol\/new-evidence-from-the-hodge-lab-shows-that-moderate-alcohol-drinking-exacerbates-brain-and-behavioral-pathologies-associated-with-alzheimers-disease\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/www.med.unc.edu\/alcohol\/new-evidence-from-the-hodge-lab-shows-that-moderate-alcohol-drinking-exacerbates-brain-and-behavioral-pathologies-associated-with-alzheimers-disease\/\"},\"author\":{\"name\":\"Brooke Mansfield\",\"@id\":\"https:\/\/www.med.unc.edu\/alcohol\/#\/schema\/person\/0a870a7f81914934009eea9eda3d7199\"},\"headline\":\"New evidence from the Hodge Lab shows that moderate alcohol drinking exacerbates brain and behavioral pathologies associated with Alzheimer\u2019s disease\",\"datePublished\":\"2019-11-13T18:41:16+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/www.med.unc.edu\/alcohol\/new-evidence-from-the-hodge-lab-shows-that-moderate-alcohol-drinking-exacerbates-brain-and-behavioral-pathologies-associated-with-alzheimers-disease\/\"},\"wordCount\":193,\"publisher\":{\"@id\":\"https:\/\/www.med.unc.edu\/alcohol\/#organization\"},\"articleSection\":[\"News\"],\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.med.unc.edu\/alcohol\/new-evidence-from-the-hodge-lab-shows-that-moderate-alcohol-drinking-exacerbates-brain-and-behavioral-pathologies-associated-with-alzheimers-disease\/\",\"url\":\"https:\/\/www.med.unc.edu\/alcohol\/new-evidence-from-the-hodge-lab-shows-that-moderate-alcohol-drinking-exacerbates-brain-and-behavioral-pathologies-associated-with-alzheimers-disease\/\",\"name\":\"New evidence from the Hodge Lab shows that moderate alcohol drinking exacerbates brain and behavioral pathologies associated with Alzheimer\u2019s disease | Bowles Center for Alcohol Studies\",\"isPartOf\":{\"@id\":\"https:\/\/www.med.unc.edu\/alcohol\/#website\"},\"datePublished\":\"2019-11-13T18:41:16+00:00\",\"breadcrumb\":{\"@id\":\"https:\/\/www.med.unc.edu\/alcohol\/new-evidence-from-the-hodge-lab-shows-that-moderate-alcohol-drinking-exacerbates-brain-and-behavioral-pathologies-associated-with-alzheimers-disease\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.med.unc.edu\/alcohol\/new-evidence-from-the-hodge-lab-shows-that-moderate-alcohol-drinking-exacerbates-brain-and-behavioral-pathologies-associated-with-alzheimers-disease\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/www.med.unc.edu\/alcohol\/new-evidence-from-the-hodge-lab-shows-that-moderate-alcohol-drinking-exacerbates-brain-and-behavioral-pathologies-associated-with-alzheimers-disease\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/www.med.unc.edu\/alcohol\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"New evidence from the Hodge Lab shows that moderate alcohol drinking exacerbates brain and behavioral pathologies associated with Alzheimer\u2019s disease\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.med.unc.edu\/alcohol\/#website\",\"url\":\"https:\/\/www.med.unc.edu\/alcohol\/\",\"name\":\"Bowles Center for Alcohol Studies\",\"description\":\"\",\"publisher\":{\"@id\":\"https:\/\/www.med.unc.edu\/alcohol\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.med.unc.edu\/alcohol\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/www.med.unc.edu\/alcohol\/#organization\",\"name\":\"Bowles Center for Alcohol Studies\",\"url\":\"https:\/\/www.med.unc.edu\/alcohol\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/www.med.unc.edu\/alcohol\/#\/schema\/logo\/image\/\",\"url\":\"https:\/\/www.med.unc.edu\/alcohol\/wp-content\/uploads\/sites\/515\/2018\/05\/Bowles-Center-for-Alcohol-Studies_logo_rgb_h.png\",\"contentUrl\":\"https:\/\/www.med.unc.edu\/alcohol\/wp-content\/uploads\/sites\/515\/2018\/05\/Bowles-Center-for-Alcohol-Studies_logo_rgb_h.png\",\"width\":1489,\"height\":151,\"caption\":\"Bowles Center for Alcohol Studies\"},\"image\":{\"@id\":\"https:\/\/www.med.unc.edu\/alcohol\/#\/schema\/logo\/image\/\"}},{\"@type\":\"Person\",\"@id\":\"https:\/\/www.med.unc.edu\/alcohol\/#\/schema\/person\/0a870a7f81914934009eea9eda3d7199\",\"name\":\"Brooke Mansfield\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/www.med.unc.edu\/alcohol\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/secure.gravatar.com\/avatar\/7148774f0ba3ce6277fe9c6e9bcc358698e3d6909059620ca22586e676c9e532?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/secure.gravatar.com\/avatar\/7148774f0ba3ce6277fe9c6e9bcc358698e3d6909059620ca22586e676c9e532?s=96&d=mm&r=g\",\"caption\":\"Brooke Mansfield\"},\"description\":\"Alcohol Studies Center\",\"url\":\"https:\/\/www.med.unc.edu\/alcohol\/author\/brookek\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"New evidence from the Hodge Lab shows that moderate alcohol drinking exacerbates brain and behavioral pathologies associated with Alzheimer\u2019s disease | Bowles Center for Alcohol Studies","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.med.unc.edu\/alcohol\/new-evidence-from-the-hodge-lab-shows-that-moderate-alcohol-drinking-exacerbates-brain-and-behavioral-pathologies-associated-with-alzheimers-disease\/","og_locale":"en_US","og_type":"article","og_title":"New evidence from the Hodge Lab shows that moderate alcohol drinking exacerbates brain and behavioral pathologies associated with Alzheimer\u2019s disease | Bowles Center for Alcohol Studies","og_description":"New evidence from the Hodge Lab shows that moderate alcohol drinking exacerbates brain and behavioral pathologies associated with Alzheimer\u2019s disease &nbsp; The consequences of non-dependent alcohol drinking on health and well-being in older adults is not fully understood. Evidence suggests that alcohol abuse during mid-life exacerbates age-related cognitive decline and may increase the risk of &hellip; Read more","og_url":"https:\/\/www.med.unc.edu\/alcohol\/new-evidence-from-the-hodge-lab-shows-that-moderate-alcohol-drinking-exacerbates-brain-and-behavioral-pathologies-associated-with-alzheimers-disease\/","og_site_name":"Bowles Center for Alcohol Studies","article_published_time":"2019-11-13T18:41:16+00:00","author":"Brooke Mansfield","twitter_card":"summary_large_image","twitter_misc":{"Written by":"Brooke Mansfield","Est. reading time":"1 minute"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/www.med.unc.edu\/alcohol\/new-evidence-from-the-hodge-lab-shows-that-moderate-alcohol-drinking-exacerbates-brain-and-behavioral-pathologies-associated-with-alzheimers-disease\/#article","isPartOf":{"@id":"https:\/\/www.med.unc.edu\/alcohol\/new-evidence-from-the-hodge-lab-shows-that-moderate-alcohol-drinking-exacerbates-brain-and-behavioral-pathologies-associated-with-alzheimers-disease\/"},"author":{"name":"Brooke Mansfield","@id":"https:\/\/www.med.unc.edu\/alcohol\/#\/schema\/person\/0a870a7f81914934009eea9eda3d7199"},"headline":"New evidence from the Hodge Lab shows that moderate alcohol drinking exacerbates brain and behavioral pathologies associated with Alzheimer\u2019s disease","datePublished":"2019-11-13T18:41:16+00:00","mainEntityOfPage":{"@id":"https:\/\/www.med.unc.edu\/alcohol\/new-evidence-from-the-hodge-lab-shows-that-moderate-alcohol-drinking-exacerbates-brain-and-behavioral-pathologies-associated-with-alzheimers-disease\/"},"wordCount":193,"publisher":{"@id":"https:\/\/www.med.unc.edu\/alcohol\/#organization"},"articleSection":["News"],"inLanguage":"en-US"},{"@type":"WebPage","@id":"https:\/\/www.med.unc.edu\/alcohol\/new-evidence-from-the-hodge-lab-shows-that-moderate-alcohol-drinking-exacerbates-brain-and-behavioral-pathologies-associated-with-alzheimers-disease\/","url":"https:\/\/www.med.unc.edu\/alcohol\/new-evidence-from-the-hodge-lab-shows-that-moderate-alcohol-drinking-exacerbates-brain-and-behavioral-pathologies-associated-with-alzheimers-disease\/","name":"New evidence from the Hodge Lab shows that moderate alcohol drinking exacerbates brain and behavioral pathologies associated with Alzheimer\u2019s disease | Bowles Center for Alcohol Studies","isPartOf":{"@id":"https:\/\/www.med.unc.edu\/alcohol\/#website"},"datePublished":"2019-11-13T18:41:16+00:00","breadcrumb":{"@id":"https:\/\/www.med.unc.edu\/alcohol\/new-evidence-from-the-hodge-lab-shows-that-moderate-alcohol-drinking-exacerbates-brain-and-behavioral-pathologies-associated-with-alzheimers-disease\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.med.unc.edu\/alcohol\/new-evidence-from-the-hodge-lab-shows-that-moderate-alcohol-drinking-exacerbates-brain-and-behavioral-pathologies-associated-with-alzheimers-disease\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/www.med.unc.edu\/alcohol\/new-evidence-from-the-hodge-lab-shows-that-moderate-alcohol-drinking-exacerbates-brain-and-behavioral-pathologies-associated-with-alzheimers-disease\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/www.med.unc.edu\/alcohol\/"},{"@type":"ListItem","position":2,"name":"New evidence from the Hodge Lab shows that moderate alcohol drinking exacerbates brain and behavioral pathologies associated with Alzheimer\u2019s disease"}]},{"@type":"WebSite","@id":"https:\/\/www.med.unc.edu\/alcohol\/#website","url":"https:\/\/www.med.unc.edu\/alcohol\/","name":"Bowles Center for Alcohol Studies","description":"","publisher":{"@id":"https:\/\/www.med.unc.edu\/alcohol\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.med.unc.edu\/alcohol\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Organization","@id":"https:\/\/www.med.unc.edu\/alcohol\/#organization","name":"Bowles Center for Alcohol Studies","url":"https:\/\/www.med.unc.edu\/alcohol\/","logo":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.med.unc.edu\/alcohol\/#\/schema\/logo\/image\/","url":"https:\/\/www.med.unc.edu\/alcohol\/wp-content\/uploads\/sites\/515\/2018\/05\/Bowles-Center-for-Alcohol-Studies_logo_rgb_h.png","contentUrl":"https:\/\/www.med.unc.edu\/alcohol\/wp-content\/uploads\/sites\/515\/2018\/05\/Bowles-Center-for-Alcohol-Studies_logo_rgb_h.png","width":1489,"height":151,"caption":"Bowles Center for Alcohol Studies"},"image":{"@id":"https:\/\/www.med.unc.edu\/alcohol\/#\/schema\/logo\/image\/"}},{"@type":"Person","@id":"https:\/\/www.med.unc.edu\/alcohol\/#\/schema\/person\/0a870a7f81914934009eea9eda3d7199","name":"Brooke Mansfield","image":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.med.unc.edu\/alcohol\/#\/schema\/person\/image\/","url":"https:\/\/secure.gravatar.com\/avatar\/7148774f0ba3ce6277fe9c6e9bcc358698e3d6909059620ca22586e676c9e532?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/7148774f0ba3ce6277fe9c6e9bcc358698e3d6909059620ca22586e676c9e532?s=96&d=mm&r=g","caption":"Brooke Mansfield"},"description":"Alcohol Studies Center","url":"https:\/\/www.med.unc.edu\/alcohol\/author\/brookek\/"}]}},"featured_image":false,"featured_image_medium":false,"featured_image_medium_large":false,"featured_image_large":false,"featured_image_thumbnail":false,"featured_image_alt":false,"category_details":[{"name":"News","link":"https:\/\/www.med.unc.edu\/alcohol\/category\/news\/"}],"tag_details":[],"_links_to":[],"_links_to_target":[],"_links":{"self":[{"href":"https:\/\/www.med.unc.edu\/alcohol\/wp-json\/wp\/v2\/posts\/1344","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.med.unc.edu\/alcohol\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.med.unc.edu\/alcohol\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.med.unc.edu\/alcohol\/wp-json\/wp\/v2\/users\/63912"}],"replies":[{"embeddable":true,"href":"https:\/\/www.med.unc.edu\/alcohol\/wp-json\/wp\/v2\/comments?post=1344"}],"version-history":[{"count":0,"href":"https:\/\/www.med.unc.edu\/alcohol\/wp-json\/wp\/v2\/posts\/1344\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.med.unc.edu\/alcohol\/wp-json\/wp\/v2\/media?parent=1344"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.med.unc.edu\/alcohol\/wp-json\/wp\/v2\/categories?post=1344"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.med.unc.edu\/alcohol\/wp-json\/wp\/v2\/tags?post=1344"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}