{"id":2355,"date":"2023-08-15T13:13:57","date_gmt":"2023-08-15T17:13:57","guid":{"rendered":"https:\/\/www.med.unc.edu\/alcohol\/?p=2355"},"modified":"2023-08-15T13:13:57","modified_gmt":"2023-08-15T17:13:57","slug":"morrow-lab-publishes-research-on-brain-activity-during-stress-in-rats","status":"publish","type":"post","link":"https:\/\/www.med.unc.edu\/alcohol\/morrow-lab-publishes-research-on-brain-activity-during-stress-in-rats\/","title":{"rendered":"Morrow Lab Publishes Research on Brain Activity During Stress in Rats"},"content":{"rendered":"<p>Leslie Morrow, PhD, and her lab recently published their research on the deleterious interaction between the neurosteroid (3\u03b1,5\u03b1)3-hydroxypregnan-20-one (3\u03b1,5\u03b1-THP) and the mu-opioid system activation during forced swim stress in rats in the journal of Biomolecules. In a previous study, Dr. Morrow and her lab observed that 3\u03b1,5\u03b1-THP down-regulation of HPA axis activity during stress is sex-, brain region-, and stressor-dependent. The team observed a deleterious submersion behavior in response to 3\u03b1,5\u03b1-THP (15 mg\/kg) during forced swim stress that led them to investigate how 3\u03b1,5\u03b1-THP might affect behavioral coping strategies engaged in by the animal. Dr. Morrow and her lab investigated the synergic effects of 3\u03b1,5\u03b1-THP\/opiate system activation in this behavior, provided the well-established involvement of the opioid system in HPA axis activation and its interaction with GABAergic neurosteroids. The results suggest that 3\u03b1,5\u03b1-THP has a deleterious effect combined with forced swim stress, which together induced an exacerbation of the opioid system, resulting in submersion behavior. The study is the first to demonstrate a possible deleterious behavior due to interaction between 3\u03b1,5\u03b1-THP and the opioid system in the context of forced swim stress. These findings call for future direct investigation of 3\u03b1,5\u03b1-THP and opiate interactions. The results may be important for enhancing the understanding of limitations of 3\u03b1,5\u03b1-THP in the treatment of neuropsychiatric disease and the development of new treatments for patients with neuropsychiatric disorders that involve HPA axis activation. The study can be accessed at <a href=\"https:\/\/www.mdpi.com\/2218-273X\/13\/8\/1205\">https:\/\/www.mdpi.com\/2218-273X\/13\/8\/1205<\/a>.<\/p>\n<p>Boero G, McFarland MH, Tyler RE, O\u2019Buckley TK, Ch\u00e9ry SL, Robinson DL, Besheer J, Morrow AL. Deleterious Interaction between the Neurosteroid (3\u03b1,5\u03b1)3-Hydroxypregnan-20-One (3\u03b1,5\u03b1-THP) and the Mu-Opioid System Activation during Forced Swim Stress in Rats.\u00a0<em>Biomolecules<\/em>. 2023; 13(8):1205. https:\/\/doi.org\/10.3390\/biom13081205<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Leslie Morrow, PhD, and her lab recently published their research on the deleterious interaction between the neurosteroid (3\u03b1,5\u03b1)3-hydroxypregnan-20-one (3\u03b1,5\u03b1-THP) and the mu-opioid system activation during forced swim stress in rats in the journal of Biomolecules. In a previous study, Dr. Morrow and her lab observed that 3\u03b1,5\u03b1-THP down-regulation of HPA axis activity during stress is &hellip; <a href=\"https:\/\/www.med.unc.edu\/alcohol\/morrow-lab-publishes-research-on-brain-activity-during-stress-in-rats\/\" aria-label=\"Read more about Morrow Lab Publishes Research on Brain Activity During Stress in Rats\">Read more<\/a><\/p>\n","protected":false},"author":15215,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":"","_links_to":"","_links_to_target":""},"categories":[1],"tags":[],"class_list":["post-2355","post","type-post","status-publish","format-standard","hentry","category-news","odd"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Morrow Lab Publishes Research on Brain Activity During Stress in Rats | Bowles Center for Alcohol Studies<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.med.unc.edu\/alcohol\/morrow-lab-publishes-research-on-brain-activity-during-stress-in-rats\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Morrow Lab Publishes Research on Brain Activity During Stress in Rats | Bowles Center for Alcohol Studies\" \/>\n<meta property=\"og:description\" content=\"Leslie Morrow, PhD, and her lab recently published their research on the deleterious interaction between the neurosteroid (3\u03b1,5\u03b1)3-hydroxypregnan-20-one (3\u03b1,5\u03b1-THP) and the mu-opioid system activation during forced swim stress in rats in the journal of Biomolecules. In a previous study, Dr. Morrow and her lab observed that 3\u03b1,5\u03b1-THP down-regulation of HPA axis activity during stress is &hellip; Read more\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.med.unc.edu\/alcohol\/morrow-lab-publishes-research-on-brain-activity-during-stress-in-rats\/\" \/>\n<meta property=\"og:site_name\" content=\"Bowles Center for Alcohol Studies\" \/>\n<meta property=\"article:published_time\" content=\"2023-08-15T17:13:57+00:00\" \/>\n<meta name=\"author\" content=\"Jennie Vaughn\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Jennie Vaughn\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" 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