{"id":2535,"date":"2024-12-02T14:12:31","date_gmt":"2024-12-02T19:12:31","guid":{"rendered":"https:\/\/www.med.unc.edu\/alcohol\/?p=2535"},"modified":"2024-12-02T14:12:31","modified_gmt":"2024-12-02T19:12:31","slug":"lopez-discovers-new-mechanism-for-allopregnanolone-inhibition-of-inflammatory-signaling","status":"publish","type":"post","link":"https:\/\/www.med.unc.edu\/alcohol\/lopez-discovers-new-mechanism-for-allopregnanolone-inhibition-of-inflammatory-signaling\/","title":{"rendered":"Lopez discovers new mechanism for allopregnanolone inhibition of inflammatory signaling"},"content":{"rendered":"

Alejandro Lopez, a graduate research assistant at the Bowles Center for Alcohol Studies, has just discovered a new mechanism for allopregnanolone inhibition of inflammatory signaling.<\/p>\n

Allopregnanolone inhibits binding of lipopolysaccaride (LPS) to it\u2019s binding site in the binding pocket of the toll-like receptor: Myeloid differentiation factor-2 (TLR4:MD2) protein complex with nanomolar affinity. \u00a0Such high affinity suggests that endogenous levels of allopregnanolone are sufficient to inhibit inflammatory TLR signaling in healthy humans.<\/p>\n

Lopez also found that allopregnanolone blocks other components of the TLR4 activation mechanism in the brain of alcohol-preferring P rats, suggesting this might contribute to its ability to reduce excessive drinking in these rats. \u00a0The discovery was published in BIomolecules last month:\u00a0 Lopez_Biomolecules_2024<\/a>.<\/p>\n

Lopez is a member of the A. Leslie Morrow Lab.<\/p>\n","protected":false},"excerpt":{"rendered":"

Alejandro Lopez, a graduate research assistant at the Bowles Center for Alcohol Studies, has just discovered a new mechanism for allopregnanolone inhibition of inflammatory signaling. Allopregnanolone inhibits binding of lipopolysaccaride (LPS) to it\u2019s binding site in the binding pocket of the toll-like receptor: Myeloid differentiation factor-2 (TLR4:MD2) protein complex with nanomolar affinity. \u00a0Such high affinity … Read more<\/a><\/p>\n","protected":false},"author":15215,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":"","_links_to":"","_links_to_target":""},"categories":[1],"tags":[],"class_list":["post-2535","post","type-post","status-publish","format-standard","hentry","category-news","odd"],"acf":[],"yoast_head":"\nLopez discovers new mechanism for allopregnanolone inhibition of inflammatory signaling | Bowles Center for Alcohol Studies<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.med.unc.edu\/alcohol\/lopez-discovers-new-mechanism-for-allopregnanolone-inhibition-of-inflammatory-signaling\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Lopez discovers new mechanism for allopregnanolone inhibition of inflammatory signaling | Bowles Center for Alcohol Studies\" \/>\n<meta property=\"og:description\" content=\"Alejandro Lopez, a graduate research assistant at the Bowles Center for Alcohol Studies, has just discovered a new mechanism for allopregnanolone inhibition of inflammatory signaling. Allopregnanolone inhibits binding of lipopolysaccaride (LPS) to it\u2019s binding site in the binding pocket of the toll-like receptor: Myeloid differentiation factor-2 (TLR4:MD2) protein complex with nanomolar affinity. \u00a0Such high affinity … Read more\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.med.unc.edu\/alcohol\/lopez-discovers-new-mechanism-for-allopregnanolone-inhibition-of-inflammatory-signaling\/\" \/>\n<meta property=\"og:site_name\" content=\"Bowles Center for Alcohol Studies\" \/>\n<meta property=\"article:published_time\" content=\"2024-12-02T19:12:31+00:00\" \/>\n<meta name=\"author\" content=\"Jennie Vaughn\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Jennie Vaughn\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script 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