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The National Institute on Alcohol Abuse and Alcoholism has awarded a 5-year K08 Career Development Award to Leon G. Coleman Jr, MD, PhD of the Bowles Center for Alcohol Studies, to study the central and peripheral immune responses to ethanol.<\/p>\n
Alcohol abuse causes dysfunction of immune responses both in the brain and the periphery. Immune dysfunction in the brain contributes to the pathology of alcoholism, while immune dysfunction in the periphery contributes to systemic disease pathologies and worsened outcomes in the setting of critical illness.<\/p>\n
Coleman will be mentored by both Fulton T. Crews, PhD (Director of the Bowles Center for Alcohol Studies) and Bruce Cairns, MD (Director of the North Carolina Jaycee Burn Center) during the award period. The award supports additional research on Coleman\u2019s discovery that alcohol increases expression of the immune signaling Toll-like Receptor 7 as well as a novel endogenous receptor agonist, e.g. the microRNA (let-7b), that contributes to neuroimmune gene induction and neurodegeneration. \u201cWe will also study these signaling systems in the periphery and how they impact alcoholism\u201d Coleman said.<\/p>\n
\u201cInflammation is a key aspect of many alcohol-related diseases,\u201d Coleman said. \u201cIf we discover how alcohol abuse causes immune dysfunction, leading to inflammation, we could develop new therapies for both alcoholism and the peripheral diseases associated with alcohol abuse.\u201d<\/p>\n
Ultimately, the goal of this project is to better understand how alcohol abuse causes inflammation in the brain and other organs, and to identify novel therapeutic approaches for the treatment of alcoholism and alcohol-related diseases.<\/p>\n","protected":false},"excerpt":{"rendered":"
The National Institute on Alcohol Abuse and Alcoholism has awarded a 5-year K08 Career Development Award to Leon G. Coleman Jr, MD, PhD of the Bowles Center for Alcohol Studies, to study the central and peripheral immune responses to ethanol. Alcohol abuse causes dysfunction of immune responses both in the brain and the periphery. Immune … Read more<\/a><\/p>\n","protected":false},"author":63912,"featured_media":307,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":"","_links_to":"","_links_to_target":""},"categories":[1],"tags":[],"class_list":["post-306","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news","odd"],"acf":[],"yoast_head":"\nLeon Coleman receives NIH Career Development Award to study immune responses to ethanol. | Bowles Center for Alcohol Studies<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.med.unc.edu\/alcohol\/leon-coleman-receives-nih-career-development-award-to-study-immune-responses-to-ethanol\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Leon Coleman receives NIH Career Development Award to study immune responses to ethanol. | Bowles Center for Alcohol Studies\" \/>\n<meta property=\"og:description\" content=\"The National Institute on Alcohol Abuse and Alcoholism has awarded a 5-year K08 Career Development Award to Leon G. 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