Transgenic and Knockout Rat Services

The Animal Models Core offers a full range of rat genetic modification services including pronuclear microinjection for production of transgenic rats using plasmid or BAC transgenes and production of knockout/knockin rats by injection of CRISPR/Cas9 nucleases.

Genetically Engineered Rat Services

The availability of new tools for genetic modification of rats is leading many researchers to reconsider rats as a model of choice. The Animal Models Core offers a full range of rat genetic engineering services including

Production of transgenic rats using plasmid or BAC transgenes
Production of knockout rats by injection of CRISPR/Cas9 nucleases
Production of knockin rats or conditional knockout rats by injection of CRISPR/Cas9 nucleases
Production and validation of CRISPR/Cas9 nucleases for rat genome modification
BAC recombineering, plasmid cloning, etc. to support rat projects
Mutation screening, rat genotyping, and rat breeding services