Burn Help Trial

The BURN HELP Trial is a pilot multi-site randomized control trial investigating the ability of propranolol to improve recovery in burn patients with specific genotypes. Patients with particular genotypes who are admitted to one of four major burn centers in the Burn TRYUMPH Research Network are enrolled. This project is supported by the UNC CTRC, The Jaycee Burn Center, and the Department of Anesthesiology. Dr. McLean is PI of this study.

Status: ended

Study Sites and Network

OSPREY Burn Map

Publications, Abstracts and Presentations

Refereed Publications:

  1. Orrey DC, Bortsov AV, Hoskins JM, Shupp JW, Jones SW, Cicuto BJ, Hwang J, Jordan MH, Holmes JH, Haith LR, Roane BM, Diatchenko L, Cairns BA, McLean SA.  Catechol-O-methyltransferase genotype predicts pain severity in hospitalized burn patients. Accepted Journal of Burn Care and Research.

Refereed Abstracts:

  1. Orrey D, Bortsov A, Shupp J, Jones S, Hwang J, Jordan M, Holmes J, Haith L, Cairns B, Liberzon I, McLean SA. Individuals with Elevated PTSD Symptoms Experience Increased Itch Symptom Morbidity after Major Burn Injury. Presented at the Annual Meeting of the Society of Biological Psychiatry, Philadelphia, PA, May 2012.
  2. Orrey D, Bortsov A, Liberzon I, Shupp JW, Jones S, Hwang J, Jordan MH, Holmes J, Haith L, Cairns B, McLean SA. Failure of propranolol to decrease anxiety and PTSD symptoms in a genotype-based RCT of patients with major thermal burn injury. Presented at the Annual Meeting of the Society of Biological Psychiatry, Philadelphia, PA, May 2012.
  3. Orrey DC, Zhao S, Bair E, Bortsov AV, Shupp JW, Jones SW, Hwang J, Jordan MH, Holmes JH, Haith LR, Cairns BA, McLean, SA. Smokers Experience Increased Pain and Itch After Major Burn Injury.  Presented at the annual meeting of the American Burn Association, Seattle, WA, 2012.
  4. Tomecka M, Orrey D, Bortsov A, Shupp J, Jordan M, Jones S, Holmes J, Haith L, Cairns B, McLean SA.  Itch Symptoms are Strongly Associated with Pain Symptoms in Patients with Major Thermal Burn Injury. Accepted for poster presentation at the Annual Meeting of the American Society of Anesthesiologists, Chicago, IL, 2011.
  5. Orrey DC, Shupp J, Jones SW, Cicuto B, Jordan M, Holmes J, Haith L, Cairns B, McLean SA. Results of a Pilot Multi-centered RCT of Propranolol to Decrease Pain in Admitted Burn Patients.  Accepted for poster presentation at the Annual Meeting of the American Society of Anesthesiologists, Chicago, IL, 2011.
  6. Orrey DC, Bortsov A, Shupp J, Cicuto B, Jordan M, Holmes J, Haith L, Cairns B, McLean SA.  Catechol-O-methyltransferase genotype predicts pain severity in hospitalized burn patients. Presented at the Annual Meeting of the American Society of Anesthesiologists, Chicago, IL, 2011.
  7. Orrey D, Shupp J, Hoskins J, Platts-Mills T, Bortsov A, Bangdiwala S, Haith L, Diatchenko L, Holmes J, Jordan M, Cairns B, McLean SA. Pilot multicenter, genotype-based, randomized, double-blind, placebo-controlled trial of propranolol to reduce initial pain symptoms in patients with major burn injury. Presented at the Annual Meeting of the American Pain Society, Austin, TX, 2011.
  8. Orrey DC, Shupp J, Hoskins JM, Platts-Mills TF, Bortsov AV, Bangdiwala SI, Jones SW, Cicuto BJ, Haith LR, Diatchenko L, Holmes JH, Jordan MH, Cairns BA, McLean SA. Feasibility and Acceptability of a Genotype-Specific Randomized Controlled Trial (RCT) of Pain Treatment in a Research Network Burn Center Population. Presented at the annual meeting of the American Burn Association in Chicago, IL, 2011.
  9. Halawa O, Roane BM, Orrey D, Whittington K, Soward AC, Jones S, Cairns B, McLean SA. Feasibility and acceptability of a genotype-specific RCT of pain treatment in a burn population. Presented at the Annual Meeting of the American Society of Anesthesiologists, San Diego, CA, 2010.
  • Names in bold indicate a member of the TRYUMPH team.

 

Photos

Dani ASA

Danielle Orrey at the Annual Meeting of the American Pain Society 2011, Austin, TX


Omar ASA

Omar Halawa at the Annual Meeting of the American Society of Anesthesiologists 2010, San Diego, CA