MicroRNA are small post-transcriptional regulators of gene expression, which have been shown to play critical roles in a variety of diseases, from cancer to heart disease. However, their role in post-trauma pain development is poorly understood. This study aims to show a) that microRNA are important mediators in the transition from acute to chronic pain following trauma such as motor vehicle collision and sexual assault and b) that microRNA regulate a number of gene-transcripts that are integral to pain pathogenesis. The ultimate goal of this research is to define novel targets for therapeutic intervention. Sarah Linnstaedt, PhD is PI of this study.
Publications, Abstracts and Presentations
- Linnstaedt SD, Walker MG, Parker JS, Sons RL, Velilla MA, Pearson C, O'Neil BJ, Zimny E, Lewandowski C, Damiron K, Hendry PL, Barnes S, Rosenberg M, Hammond SM, McLean SA Circulating microRNA evaluated in the early aftermath of motor vehicle collision predict widespread pain development in African Americans and provide potential pathogenic insights: results of a preliminary analysis Presented at the Annual Meeting of the American Pain Society, Tampa FL, 2014.
- Linnstaedt SD, Walker MG, Bortsov AV, Swor RA, Jones JS, Lee DC, Peak DA, Domeier RM, Rathlev NK, McLean SA The ADRA2A genetic variant rs3750635 influences extent and severity of acute pain after motor vehicle collision and may do so by regulating microRNA function Presented at the Annual Meeting of the American Pain Society, Tampa FL, 2014.
- Linnstaedt SD, McCarthy KR, Riker KD, Kutchko KM, Laederach A, McLean SA A genetic variant in the glucocorticoid receptor co-chaperone FKBP5, associated with chronic pain vulnerability, changes RNA secondary structure and alters binding by miR-320a. To be presented at the 15th World Congress on Pain, Buenos Aires Argentina, 2014.
The current members of the Linnstaedt Lab