{"id":2485,"date":"2020-10-29T11:20:21","date_gmt":"2020-10-29T15:20:21","guid":{"rendered":"https:\/\/www.med.unc.edu\/barc\/?post_type=directory&p=2485"},"modified":"2025-04-21T13:42:03","modified_gmt":"2025-04-21T17:42:03","slug":"austin-hepperla","status":"publish","type":"directory","link":"https:\/\/www.med.unc.edu\/barc\/directory\/austin-hepperla\/","title":{"rendered":"Austin Hepperla, PhD"},"content":{"rendered":"
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    Spt6-Spn1 interaction is required for RNA Polymerase II association and precise nucleosome positioning along transcribed genes<\/a><\/h3>\n

    Abstract Spt6-Spn1 is an essential histone chaperone complex that associates with RNA Polymerase II (RNAPII) and reassembles nucleosomes during gene transcription. While the interaction between Spt6 and Spn1 is important for its histone deposition and transcription functions, a precise mechanistic understanding is still limited. Here, using temperature sensitive alleles of spt6 and spn1 that disrupt … Read more<\/a><\/p>\n<\/p>\n

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    CHD4 and SMYD1 repress common transcriptional programs in the developing heart<\/a><\/h3>\n

    Abstract Regulation of chromatin states is essential for proper temporal and spatial gene expression. Chromatin states are modulated by remodeling complexes composed of components that have enzymatic activities. CHD4 is the catalytic core of the nucleosome remodeling and deacetylase (NuRD) complex, which represses gene transcription. However, it remains to be determined how CHD4, a ubiquitous … Read more<\/a><\/p>\n<\/p>\n

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     <\/p>\n","protected":false},"excerpt":{"rendered":"

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