######################################## #Summary statistics for GWAS analysis of 101 ROI volumes in meta-analysis of five datasets including UK Biobank (UKB), the UK Biobank (UKB) study, the Human Connectome Project (HCP) study, the Pediatric Imaging, Neurocognition, and Genetics (PING) study, the Philadelphia Neurodevelopmental Cohort (PNC) study, and the Alzheimer's Disease Neuroimaging Initiative (ADNI) study. #Bingxin Zhao (bingxin@unc.edu) ######################################## Sample size n=21,821 Number of reported SNPs p=8,938,185 (Chromosomes 1-22) Version: May24, 2019 ######################################## Meta-analysis was performed by METAL:https://genome.sph.umich.edu/wiki/METAL_Quick_Start Each file contains the following columns: # Marker - this is the marker name (rsid) # Allele1 - the first allele for this marker in the first file where it occurs (A1 in UKB GWAS) # Allele2 - the second allele for this marker in the first file where it occurs (A2 in UKB GWAS) # Weight - the sum of the individual study weights (typically, N) for this marker # Z-score - the combined z-statistic for this marker # P-value - meta-analysis p-value # Direction - summary of effect direction for each study, with one '+' or '-' per study (the order of studies are UKB, ADNI, PING, PNC, and HCP, from left to right) ######################################## Reference: Zhao et al (2019) GWAS of 19,629 individuals identifies novel genetic variants for regional brain volumes and refines their genetic co-architecture with cognitive and mental health traits. (https://doi.org/10.1101/586339) ######################################## This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License (https://creativecommons.org/licenses/by-nc-sa/4.0/) Particularly, you agree not to attempt to identify individual participants and not to use these data for projects that may lead to stigmatizing individuals or groups of individuals. When reporting results of research that utilizes these data, we request that you cite the original publication. Commercial use: If you want to use the GWAS sumstats commercially, you must first get our permission to do so. Please send an e-mail to Hongtu Zhu (htzhu@email.unc.edu).