{"id":2894,"date":"2018-09-16T19:54:28","date_gmt":"2018-09-16T23:54:28","guid":{"rendered":"https:\/\/www.med.unc.edu\/bigs2?page_id=2894&preview_id=2894"},"modified":"2019-10-08T18:13:53","modified_gmt":"2019-10-08T22:13:53","slug":"white-matter-integrity","status":"publish","type":"page","link":"https:\/\/www.med.unc.edu\/bigs2\/projects\/white-matter-integrity\/","title":{"rendered":"White Matter Integrity"},"content":{"rendered":"
\n
\n
\n
\n
\n

White Matter Integrity in Neurological and Neuropsychiatric Diseases with Diffusion-weighted MRI<\/b><\/h4>\n

Introduction<\/h4>\n

A variety of neurological and neuropsychiatric diseases, such as Alzheimer\u2019s disease (AD) and autism, are related to white matter degeneration over the entire brain. In previous studies, Previous studies usually only calculated either some summary statistics over regions of interest (ROI analysis) or some statistics along mean skeleton lines (Tract Based Spatial Statistic [TBSS]), so they cannot quantify subtle local white matter alterations along major tracts.<\/p>\n

Methods<\/h4>\n

We propose an automated Multi-Atlas Tract Extraction (autoMATE) algorithm. We can reliably extract 18 major white matter tracts from whole brain tractography in a population with autoMATE. We then extract multiple DWI-derived parameters of WM integrity (e.g. fractional anisotropy [FA]\/mean diffusivity [MD]\/axial diffusivity [AxD]\/radial diffusivity [RD]) along the white matter tracts across all subjects. To conduct a population study, we apply a fiber matching scheme to establish fiber correspondence for each tract across the population. A novel statistical functional analysis method-FADTTS (Functional Analysis for Diffusion Tensor Tract Statistics) was applied to quantify degenerative patterns along WM tracts across different stages of the disease. We performed the algorithm on an AD study of 200 subjects: 49 healthy elderly normal controls (NC), 110 with mild cognitive impairment (MCI), and 41 AD patients.<\/p>\n

Findings<\/h4>\n

Figures 1(a-d) show the 3D local profiles of the 4 parameters of the 18 WM tracts in the group comparisons for MCI versus NC (NC-baseline), AD versus MCI (MCI-baseline), and AD versus NC (NC-baseline), respectively. The \u2013log10 p-values correspond to the color bars. Redder colors indicate greater differences. We corrected for multiple comparisons across all points on each tract by using the false discovery rate (FDR). Group differences were considered statistically significant at points with \u2013log values>1.3 (FDR corrected p=0.05). We marked the significant areas with positive change in the parameter with the \u201c+\u201d sign and negative change with the \u201c\u2013\u201d sign.
\n
\n
\n
\n<\/p>\n

 <\/p>\n

References<\/h4>\n

Y. Jin, Y. Shi, L. Zhan, B.A. Gutman, G.I. de Zubicaray, K.L. McMahon, M.J. Wright, A.W. Toga, and P.M. Thompson, \u201cAutomatic clustering of white matter fibers in brain diffusion MRI with an application to genetics,\u201d NeuroImage 100, 75-90, 2014.<\/p>\n

Y. Jin, C. Huang, M. Daianu, L. Zhan, E.L. Dennis, R.I. Reid, C.R. Jack, Jr, H. Zhu, P.M. Thomposn, and the Alzheimer\u2019s Disease Neuroimaging Initiative, \u201c3D tract-specific local and global analysis of white matter integrity in Alzheimer\u2019s disease,\u201d Human Brain Mapping, in press, 2016.<\/p>\n<\/div>\n<\/div>\n<\/div>\n

\n

<\/p>\n<\/div>\n<\/div>\n

\n

 <\/p>\n<\/div>\n<\/div>\n

<\/p>\n","protected":false},"excerpt":{"rendered":"

White Matter Integrity in Neurological and Neuropsychiatric Diseases with Diffusion-weighted MRI Introduction A variety of neurological and neuropsychiatric diseases, such as Alzheimer\u2019s disease (AD) and autism, are related to white matter degeneration over the entire brain. In previous studies, Previous studies usually only calculated either some summary statistics over regions of interest (ROI analysis) or … Read more<\/a><\/p>\n","protected":false},"author":55348,"featured_media":0,"parent":2857,"menu_order":2,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":"","_links_to":"","_links_to_target":""},"class_list":["post-2894","page","type-page","status-publish","hentry","odd"],"acf":[],"yoast_head":"\nWhite Matter Integrity - BIG-S2<\/title>\n<meta name=\"robots\" content=\"noindex, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"White Matter Integrity - BIG-S2\" \/>\n<meta property=\"og:description\" content=\"White Matter Integrity in Neurological and Neuropsychiatric Diseases with Diffusion-weighted MRI Introduction A variety of neurological and neuropsychiatric diseases, such as Alzheimer\u2019s disease (AD) and autism, are related to white matter degeneration over the entire brain. In previous studies, Previous studies usually only calculated either some summary statistics over regions of interest (ROI analysis) or … Read more\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.med.unc.edu\/bigs2\/projects\/white-matter-integrity\/\" \/>\n<meta property=\"og:site_name\" content=\"BIG-S2\" \/>\n<meta property=\"article:modified_time\" content=\"2019-10-08T22:13:53+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.med.unc.edu\/bigs2\/wp-content\/uploads\/sites\/822\/2018\/09\/project_white_Fig1a.jpg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.med.unc.edu\/bigs2\/projects\/white-matter-integrity\/\",\"url\":\"https:\/\/www.med.unc.edu\/bigs2\/projects\/white-matter-integrity\/\",\"name\":\"White Matter Integrity - BIG-S2\",\"isPartOf\":{\"@id\":\"https:\/\/www.med.unc.edu\/bigs2\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/www.med.unc.edu\/bigs2\/projects\/white-matter-integrity\/#primaryimage\"},\"image\":{\"@id\":\"https:\/\/www.med.unc.edu\/bigs2\/projects\/white-matter-integrity\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/www.med.unc.edu\/bigs2\/wp-content\/uploads\/sites\/822\/2018\/09\/project_white_Fig1a.jpg\",\"datePublished\":\"2018-09-16T23:54:28+00:00\",\"dateModified\":\"2019-10-08T22:13:53+00:00\",\"breadcrumb\":{\"@id\":\"https:\/\/www.med.unc.edu\/bigs2\/projects\/white-matter-integrity\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.med.unc.edu\/bigs2\/projects\/white-matter-integrity\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/www.med.unc.edu\/bigs2\/projects\/white-matter-integrity\/#primaryimage\",\"url\":\"https:\/\/www.med.unc.edu\/bigs2\/wp-content\/uploads\/sites\/822\/2018\/09\/project_white_Fig1a.jpg\",\"contentUrl\":\"https:\/\/www.med.unc.edu\/bigs2\/wp-content\/uploads\/sites\/822\/2018\/09\/project_white_Fig1a.jpg\",\"width\":1274,\"height\":1351},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/www.med.unc.edu\/bigs2\/projects\/white-matter-integrity\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/www.med.unc.edu\/bigs2\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Projects\",\"item\":\"https:\/\/www.med.unc.edu\/bigs2\/projects\/\"},{\"@type\":\"ListItem\",\"position\":3,\"name\":\"White Matter Integrity\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.med.unc.edu\/bigs2\/#website\",\"url\":\"https:\/\/www.med.unc.edu\/bigs2\/\",\"name\":\"BIG-S2\",\"description\":\"Biostatistics and Imaging Genomics analysis lab - Statistics & Signal\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.med.unc.edu\/bigs2\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"White Matter Integrity - BIG-S2","robots":{"index":"noindex","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"og_locale":"en_US","og_type":"article","og_title":"White Matter Integrity - BIG-S2","og_description":"White Matter Integrity in Neurological and Neuropsychiatric Diseases with Diffusion-weighted MRI Introduction A variety of neurological and neuropsychiatric diseases, such as Alzheimer\u2019s disease (AD) and autism, are related to white matter degeneration over the entire brain. In previous studies, Previous studies usually only calculated either some summary statistics over regions of interest (ROI analysis) or … Read more","og_url":"https:\/\/www.med.unc.edu\/bigs2\/projects\/white-matter-integrity\/","og_site_name":"BIG-S2","article_modified_time":"2019-10-08T22:13:53+00:00","og_image":[{"url":"https:\/\/www.med.unc.edu\/bigs2\/wp-content\/uploads\/sites\/822\/2018\/09\/project_white_Fig1a.jpg","type":"","width":"","height":""}],"twitter_card":"summary_large_image","twitter_misc":{"Est. reading time":"2 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/www.med.unc.edu\/bigs2\/projects\/white-matter-integrity\/","url":"https:\/\/www.med.unc.edu\/bigs2\/projects\/white-matter-integrity\/","name":"White Matter Integrity - BIG-S2","isPartOf":{"@id":"https:\/\/www.med.unc.edu\/bigs2\/#website"},"primaryImageOfPage":{"@id":"https:\/\/www.med.unc.edu\/bigs2\/projects\/white-matter-integrity\/#primaryimage"},"image":{"@id":"https:\/\/www.med.unc.edu\/bigs2\/projects\/white-matter-integrity\/#primaryimage"},"thumbnailUrl":"https:\/\/www.med.unc.edu\/bigs2\/wp-content\/uploads\/sites\/822\/2018\/09\/project_white_Fig1a.jpg","datePublished":"2018-09-16T23:54:28+00:00","dateModified":"2019-10-08T22:13:53+00:00","breadcrumb":{"@id":"https:\/\/www.med.unc.edu\/bigs2\/projects\/white-matter-integrity\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.med.unc.edu\/bigs2\/projects\/white-matter-integrity\/"]}]},{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.med.unc.edu\/bigs2\/projects\/white-matter-integrity\/#primaryimage","url":"https:\/\/www.med.unc.edu\/bigs2\/wp-content\/uploads\/sites\/822\/2018\/09\/project_white_Fig1a.jpg","contentUrl":"https:\/\/www.med.unc.edu\/bigs2\/wp-content\/uploads\/sites\/822\/2018\/09\/project_white_Fig1a.jpg","width":1274,"height":1351},{"@type":"BreadcrumbList","@id":"https:\/\/www.med.unc.edu\/bigs2\/projects\/white-matter-integrity\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/www.med.unc.edu\/bigs2\/"},{"@type":"ListItem","position":2,"name":"Projects","item":"https:\/\/www.med.unc.edu\/bigs2\/projects\/"},{"@type":"ListItem","position":3,"name":"White Matter Integrity"}]},{"@type":"WebSite","@id":"https:\/\/www.med.unc.edu\/bigs2\/#website","url":"https:\/\/www.med.unc.edu\/bigs2\/","name":"BIG-S2","description":"Biostatistics and Imaging Genomics analysis lab - Statistics & Signal","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.med.unc.edu\/bigs2\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"}]}},"_links_to":[],"_links_to_target":[],"_links":{"self":[{"href":"https:\/\/www.med.unc.edu\/bigs2\/wp-json\/wp\/v2\/pages\/2894","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.med.unc.edu\/bigs2\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.med.unc.edu\/bigs2\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.med.unc.edu\/bigs2\/wp-json\/wp\/v2\/users\/55348"}],"replies":[{"embeddable":true,"href":"https:\/\/www.med.unc.edu\/bigs2\/wp-json\/wp\/v2\/comments?post=2894"}],"version-history":[{"count":0,"href":"https:\/\/www.med.unc.edu\/bigs2\/wp-json\/wp\/v2\/pages\/2894\/revisions"}],"up":[{"embeddable":true,"href":"https:\/\/www.med.unc.edu\/bigs2\/wp-json\/wp\/v2\/pages\/2857"}],"wp:attachment":[{"href":"https:\/\/www.med.unc.edu\/bigs2\/wp-json\/wp\/v2\/media?parent=2894"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}