Research: Systems cancer biology and immunology, cancer therapeutic response, protein-protein interaction networks (interactomes), post-translational modifications, epigenetic regulation, signal transduction, disease marker discovery.
Effective August 2, 2019
Xian Chen PhD and Aziz Sancar MD PhD were among those who received grants at the School of Medicine during 9/15/2021 – 9/30/2021.
CRL4DCAF1/VprBP E3 ubiquitin ligase controls ribosome biogenesis, cell proliferation, and development. Authors: Xiao-Ran Han, Naoya Sasaki, Sarah Jackson, Pu Wang, Zhijun Li, Matthew Smith, Ling Xie, Xian Chen, Yanping Zhang, Bill Marzluff and Yue Xiong publishes cell proliferation research in Science Advances.
In the journal Cell Chemical Biology, researchers led by Biochemistry and Biophysics Associate Professor and Faculty Director, Quantitative Proteomics Center for Disease Marker Discovery, Xian Chen, PhD, report on potential prognostic tool that could be used to identify high-risk patients within particular subtypes of breast cancer.
Three scientists at the UNC-CH (Marcey Waters, Brian Strahl, Xian Chen) have received a $1 million grant from the W.M. Keck Foundation’s Medical Research Program to study a widespread but largely unexplored phenomenon that may be implicated in many diseases, including cancer.
Life is full of choices, and even cells come to a fork in the road. They have to decide what to do about damage to their DNA: repair the damage, force the damaged cell to die, or allow the damage to transform the cell to a tumor cell. Read more on the work from the Xian Chen lab in the Department of Biochemistry & Biophysics that was published in Cell Death & Disease.
Thursday, October 15, 2009 — Dr. Xian Chen, Associate Professor of Biochemistry and Biophysics, who along with Dr. Morgan Giddings, Associate Professor of Microbiology and Immunology have been awarded a $1.6 million 2-year “Grand Opportunities” (GO) grant from the National Human Genome Research Institute.
Lingjun Li, Ph.D., Professor, Pharmaceutical Sciences and Chemistry, University of Wisconsin-Madison Venue: TBA Talk Title: TBD Host: Xian Chen
Abstract: Protein hydroxylation affects protein stability, activity, and interactome, therefore contributing to various diseases including cancers. However, the transiency of the hydroxylation reaction hinders the identification of hydroxylase substrates.
