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Xian Chen

June 27, 2015

Research: Systems cancer biology and immunology, cancer therapeutic response, protein-protein interaction networks (interactomes), post-translational modifications, epigenetic regulation, signal transduction, disease marker discovery.

Latest Grant Awards to SOM Faculty

October 7, 2021

Xian Chen PhD and Aziz Sancar MD PhD were among those who received grants at the School of Medicine during 9/15/2021 – 9/30/2021.

Our team publishes cell proliferation research in Science Advances

January 4, 2021

CRL4DCAF1/VprBP E3 ubiquitin ligase controls ribosome biogenesis, cell proliferation, and development. Authors: Xiao-Ran Han, Naoya Sasaki, Sarah Jackson, Pu Wang, Zhijun Li, Matthew Smith, Ling Xie, Xian Chen, Yanping Zhang, Bill Marzluff and Yue Xiong publishes cell proliferation research in Science Advances.

Prognostic tool could identify high-risk breast cancer patients

March 1, 2018

In the journal Cell Chemical Biology, researchers led by Biochemistry and Biophysics Associate Professor and Faculty Director, Quantitative Proteomics Center for Disease Marker Discovery, Xian Chen, PhD, report on potential prognostic tool that could be used to identify high-risk patients within particular subtypes of breast cancer.

UNC team reports a novel DNA Damage-Dependent Tumor Suppressor

July 27, 2012

Life is full of choices, and even cells come to a fork in the road. They have to decide what to do about damage to their DNA: repair the damage, force the damaged cell to die, or allow the damage to transform the cell to a tumor cell. Read more on the work from the Xian Chen lab in the Department of Biochemistry & Biophysics that was published in Cell Death & Disease.

2022 BCBP Spring Seminar Series announced

January 18, 2022

— January 25 (Virtual) Elizabeth Kellogg, Ph.D., Assistant Professor, Dept. of Molecular Biology & Genetics Cornell University Host: Brian Kuhlman Title: Mechanistic studies of CRISPR-associated transposons (CAST) using cryo-EM   February 8 (Virtual) Peter Penzes, Ph.D., Director, Center for Autism and Neurodevelopment Northwestern University -Host: Patricia Maness Title: Synaptic biology of ankyrin   February 15 … Continued

BCBP Seminar: Lingjun Li (Univ. of WS-Madison)

December 2, 2021

Lingjun Li, Ph.D., Professor, Pharmaceutical Sciences and Chemistry, University of Wisconsin-Madison Venue: Zoom Talk Title: Advancing Biomedical Research via Innovation in Mass Spectrometry-based Approaches Host: Xian Chen