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Professor; Core Director, Macromolecular Interactions Facility


  • 2014 invited talk, Resources at the Macromolecular Interactions Facility, Structural Biology Symposium at UNC.
  • 2013 invited talk, Resources at the Macromolecular Interactions Facility, Carolina center for Genome Sciences Spring Symposium, “From Genome to Proteome: Proteomic Innovations and Technologies at UNC.
  • 2011, 2009, 2005, 2004 NIH Scientific Review committee member


Dr. Tripathy is the Director of the Macromolecular Interactions Facility, a core facility of the University of North Carolina at Chapel Hill, which provides instrumentation and resources for biophysical characterization of biological macromolecules and their interactions with cognate ligands. Research applications include:

  • Determination of solution molecular weight, oligomeric state and association/dissociation constants of macromolecules
  • Determination of on and off rates (kon and koff), stoichiometry, equilibrium binding constants and other thermodynamic parameters (∆G, ∆H and ∆S) of bimolecular interactions
  • Determination of sedimentation, diffusion and frictional coefficients, hydrodynamic and RMS radius, and second virial coefficient
  • Determinations of secondary structure, melting profile, melting temperature (Tm) and thermal stability

Dr. Tripathy provides training to faculty, post-docs, and students in experimental design, instrument operation, data analysis and interpretation one-on-one basis and through his “Macromolecular Interaction” (BIOC662) course, a critical component of the Biophysics Training Program at UNC and open to all graduate students.

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Dr. Ash Tripathy