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BCBP Seminar: Luciano Di Croce (CRG) Barcelona Spain

September 8 @ 11:00 am - 12:00 pm

Luciano Di Croce PhD of Spain

Luciano Di Croce (Centre for Genomic Regulation (CRG) Barcelona Spain

Seminar title, “Chromatin regulators in cell differentiation and cancer processes”

Host: Greg Wang

Biography

Luciano Di Croce obtained his PhD in “Molecular and Cell Biology” from the University of Rome “La Sapienza”. In 1996 he moved to the University of Marburg (Germany) as a postdoctoral fellow in the laboratory of Miguel Beato where he became interested in understanding the link between transcription and chromatin structure. After a second postdoctoral stage at the European Institute for Oncology (IEO, Milan) in the lab of PierGiuseppe Pelicci, he established his group at the Center for Genomic Regulation (CRG, Barcelona) in 2003, as an ICREA Professor. Di Croce’s group has focused its research efforts on understanding how epigenetic modifications and chromatin changes are established and, once in place, how they affect gene expression, stem cell differentiation and transformation.

Research

Understanding the genetic basis of cancers has been a topic of intense research, and hundreds of gene mutations have been identified that can cause carcinogenesis. However, in the past few years, increasing evidence has suggested that mutations are not the only genetic changes that lead to cancer. Indeed, perturbations of chromatin structure and of other epigenetic mechanisms can cause inappropriate gene expression and genomic instability, resulting in cellular transformation and malignant outgrowth.

Our research investigation is focused on understanding the role of several protein complexes that are involved in chromatin dynamics and metabolism, which when altered could participate in the establishment and maintenance of the aberrant silencing of tumor suppressor genes during transformation. Our results suggested that the Nucleosome Remodelling and Deacetylase complex (NuRD), Polycomb group of proteins (PcG) and the histone variant macroH2A are – with different timing and kinetics – involved in setting up an altered chromatin structure with aberrant gene silencing in acute promyelocytic leukemia (APL). We believe that the results of our research will lead to the identification of new biological tools with a potential impact on cancer therapeutic intervention.

Details

Date:
September 8
Time:
11:00 am - 12:00 pm
Event Categories:
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Organizer

Jamie Desoto
Phone:
919-843-9986
Email:
Jamie_Desoto@unc.edu