BCBP Seminar: Stephen Hughes PhD

Stephen H. Hughes, Ph.D., Chief of the Retroviral Replication Laboratory

National Cancer Institute

Title: Clonal Expansion of Infected Cells in People Living with HIV

Host: Ron Swanstrom

Research: 1) HIV replication, 2) retroviruses, 3) antivirals, 4) reverse transcription, 5) integration

Dr. Hughes has a B.A. in Biology from Washington University and a Ph.D. in Biochemistry from Harvard University. Throughout his career, Dr. Hughes has received numerous awards for his research in HIV. He is internationally renowned for his research on the roles of reverse transcriptase (RT) and integrase (IN).  He is interested in how HIV becomes resistant to RT and IN inhibitors, in developing drugs that are more effective against the known resistance mutations, and in how the clonal expansion of HIV-infected cells contributes to the formation and persistence of the reservoir that has made it impossible to cure HIV infections with the available drugs.  In his role as NIH Scientist Emeritus, Dr. Hughes interacts with scientists inside and outside of the HIV-DRP, providing advice and mentoring. His areas of expertise include HIV replication, retroviruses, antivirals, reverse transcription, and integration.