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Seminar: Gabe Lander PhD (Scripps)

October 8 @ 11:00 am - 12:00 pm

Oct 8 seminar- Gabe Lander

GABE LANDER, PHD, Professor, Department of Integrative Structural and Computational Biology, Scripps Research Institute                                                                     Host: Rob McGinty

“The highs and lows of cryo-EM and its use in studying molecular machines of mass destruction”

Abstract:Technical and methodological advances in single-particle cryo-electron microscopy (cryo-EM) have expanded the technique into a resolution regime that was previously only attainable by X-ray crystallography. We demonstrate that it is possible to obtain cryo-EM reconstructions of macromolecular complexes that are smaller than 100 kDa to better than 3 Å resolution using a 200 keV TEM. We also also use this technique to study AAA+ quality control proteases that regulate diverse aspects of cellular biology through specialized protein degradation. Through structure determination and biochemistry, we have established a structural framework to understand how different members of the AAA+ superfamily achieve specialized, diverse biological functions.

Details

Date:
October 8
Time:
11:00 am - 12:00 pm
Event Categories:
,

Venue

Bioinformatics 1131
130 Mason Farm Road
Chapel Hill, NC 27514 United States

Organizer

Jamie Desoto
Phone:
919-843-9986
Email:
Jamie_Desoto@unc.edu