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Seminar: Prasanna Satpute-Krishan (Uniformed Services Univ.)

January 14 @ 11:00 am - 12:00 pm

dr satpute krishnan seminar speaker

“Selective ER-Export of Misfolded Secretory Pathway Proteins for Lysosomal Degradation”

Host: Sasky Neher

ABSTRACT

We discovered that a subset of misfolded secretory pathway proteins, including variants of prion protein and amyloid precursor protein, are selectively exported out of the ER by a constitutive and stress-enhanced pathway named RESET. After RESET, these misfolded proteins are subsequently degraded in lysosomes. We now present our new unpublished findings on the mechanism by which misfolded proteins are constitutively released for degradation through RESET and how ER stress enhances this pathway. Implications for protein misfolding diseases will be discussed.

Details

Date:
January 14
Time:
11:00 am - 12:00 pm
Event Category:

Venue

Bioinformatics 1131
130 Mason Farm Road
Chapel Hill, NC 27514 United States
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Organizer

Jamie Desoto
Phone:
919-843-9986
Email:
Jamie_Desoto@unc.edu