Sep 24, 2013
from 11:00 AM to 12:00 PM
|Contact Name||Rhonda Scott|
open to the public
|Add event to calendar||
Professor, Physiology and Biophysics
University of Washington
SEMINAR: “A link between tumor suppressors, microtubule dynamics and chromosome instability”
Host: Michael Caplow, PhD
Text of seminar:
Hello, welcome to the science seminar preview from the Department of Biochemistry and Biophysics at the University of North Carolina at Chapel Hill. My name is Hash Meriesh -- student in the Biological and Biomedical Sciences program. And I would like to tell you about an upcoming seminar that you will not want to miss. On Tuesday, September 24th. Dr. Linda Wordeman - professor of physiology and biophysics at the University of Washington will be giving a talk on “A link between tumor suppressors, microtubule dynamics and chromosome instability”.
A distinct feature of mitosis is the alignment of chromosomes right down the middle of the metaphase blade? The control mechanism for this process are not well understood and deficiencies in the alignment process likely contribute to the formation of tumors. The CEK2 protein kinase - a know tumor suppressor - insures chromosomal stability my maintaining the mitotic spindle assembly. While defects in the CEK2 gene are found in nearly half of lung cancer tissues understanding how tumor suppressors such as CEK2 influence microtubule dynamics and overall chromosomal
stability may help us understand how tumor suppressor pathways are transformed leading to tumor progression and oncogene formation.
Dr. Wordeman's groups is seeking a better understanding of the
mechanism that control mitotic centimeter movement. While investigating how the chromosome is maintaining the position at the metaphase blade they found that 3 chromo-kinesins Kif18A, Kif4A and Kid all play a role in confining centimeter movement. Kif18A activity provides the most dominate mechanism for restricting movement by promoting microtubule pausing while polar-ejecting forces spatially confined the chromosome. Interesting, the pushing forces are antagonistically regulated by chromo kinesins depending on Kid for activity and antagonized by Kif4A, which directly suppresses microtubule growth.
Please join us for Dr. Linda Wordeman's seminar, Tuesday, September 24th at 11am in Bioinformatics room 1131 for what is assured to be an exciting conversation.