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Greg Wang receives a grant from Gabrielle’s Angels to study “Novel Approaches to Target PRC2 Enzymatic Complexes for the Treatment of Hematopoietic Malignancies”

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Greg Wang received a grant from Gabrielle’s Angels Foundation for Cancer Research. The purpose of Gabrielle’s Angels which “is to encourage the development of more effective therapies for patients with leukemia, lymphoma and related cancers.” Since 1996, Gabrielle’s Angel Foundation has awarded $25 million to over 130 of the nation’s best and brightest junior investigators. Eighty-nine cents of every dollar we raise funds research.

Greg’s research involves “Enzymes that modify chromatin (the physiological form of DNA) are commonly found hyper-activated among lymphoma and myeloma. Novel therapeutics needs to be developed for treating these currently incurable malignancies. We investigate the mechanisms for their hyperactivities and develop new ways for their inhibition as novel cancer therapeutic inventions.”

Dr. Wang is an Assistant Professor in the Department of Biochemistry and Biophysics and a member of UNC Lineberger Comprehensive Cancer Center. He completed a postdoctoral fellowship with David Allis in the laboratory of Chromatin Biology & Epigenetics at Rockefeller University in New York. Since joining the faculty at UNC, he has been awarded a UNC Jefferson Pilot Fellowship in Academic Medicine (2013) and a Martin D. Abeloff, MD V Scholar Award from the V Foundation for Cancer Research (2011). He is also currently completing a Howard Temin ‘Pathway to Independence’ Award in Cancer Research from the National Cancer Institute (2010–present). Dr. Wang is the first recipient of Dr. Janet D Rowley Medical Research Award, in memory and honor of Dr. Rowley’s pioneering research career in hematological cancers.

Research in his lab emphasizes chromatin biology and epigenetics. His group focuses on mechanistic understandings of how chemical modifications of chromatin define distinct patterns of mammalian genomes, control gene expression, and regulate cell proliferation versus differentiation during development, and how their deregulations lead to human diseases such as cancer, developmental disorders, and aging.

Gabrielle’s Angels Foundation for Cancer Research