{"id":4812,"date":"2015-06-23T20:39:00","date_gmt":"2015-06-24T00:39:00","guid":{"rendered":"https:\/\/www.med.unc.edu\/biochem\/directory\/mcginty\/"},"modified":"2025-08-19T14:08:56","modified_gmt":"2025-08-19T18:08:56","slug":"mcginty","status":"publish","type":"directory","link":"https:\/\/www.med.unc.edu\/biochem\/directory\/mcginty\/","title":{"rendered":"Robert McGinty"},"content":{"rendered":"<p style=\"text-align: center\"><span class=\"blue\"><em><strong>Associate Professor of Chemical Biology and Medicinal Chemistry<\/strong><\/em><\/span><\/p>\n<p style=\"text-align: center\"><span class=\"blue\"><em><strong>UNC Eshelman School of Pharmacy<\/strong><\/em><\/span><br \/>\n<span style=\"color: #333333\">Joint Appointment in Biochemistry and Biophysics<\/span><br \/>\n<span class=\"discreet\" style=\"color: #333333\">(PhD &#8211; Rockefeller University and <\/span><span class=\"discreet\" style=\"color: #333333\">MD &#8211; Cornell)<\/span><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-10603 size-thumbnail aligncenter\" src=\"https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2019\/08\/Faculty-OGE-Trained-mentor-badge-400dpi-for-website-150x150.png\" alt=\"Trained Faculty Mentor endorsed by Office of Graduate Ed UNC Chapel Hill\" width=\"150\" height=\"150\" srcset=\"https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2019\/08\/Faculty-OGE-Trained-mentor-badge-400dpi-for-website-150x150.png 150w, https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2019\/08\/Faculty-OGE-Trained-mentor-badge-400dpi-for-website-64x64.png 64w\" sizes=\"auto, (max-width: 150px) 100vw, 150px\" \/><\/p>\n<div>\n<h3><span class=\"blue\">HONORS &amp; AWARDS<\/span><\/h3>\n<ul>\n<li>2017 Searle Scholar Award<\/li>\n<li>2017 Pew-Stewart Scholar for Cancer Research<\/li>\n<\/ul>\n<h3><span class=\"blue\">RESEARCH<\/span><\/h3>\n<div id=\"pane-0-1\" class=\"tab-pane active\">\n<p>Despite every cell in the human body having a nearly identical genetic sequence, divergent patterns of gene expression lead to the development of diverse cell types and functions. These patterns are established through epigenetic changes to the composition and structure of chromatin, the physiologic state of the genome. The repeating unit of chromatin is the nucleosome, in which segments of genomic DNA are wrapped around molecular spools of histone proteins. By displaying diverse combinations of histone post-translational modifications, the nucleosome serves as an active signaling hub in the regulation of genome-templated processes. These processes, including gene expression, DNA replication and DNA damage repair, play fundamental roles in cell development and maintenance of genomic integrity. As such, inappropriate regulation of the epigenetic enzymes that write, read and erase these modifications is correlated with many human diseases, especially cancer.<\/p>\n<p>Over the past two decades, structural and biochemical studies using peptide fragments of histone proteins have elucidated many mechanisms through which epigenetic enzymes recognize histone sequences and modification patterns. However, these peptide-based approaches preclude a fundamental understanding of how epigenetic signals are integrated within more physiologic states of chromatin.<\/p>\n<p>McGinty Laboratory studies mechanisms governing epigenetic signaling at the nucleosome and chromatin levels. We use protein chemistry to reconstitute \u2018designer\u2019 nucleosomes and chromatin, containing defined patterns of post-translational modifications. When paired with structural biology, including X-ray crystallography and single particle cryo-EM, this allows us to interrogate mechanisms governing specific epigenetic signaling pathways at atomic resolution. Together with the Center for Integrative Chemical Biology and Drug Discovery, my lab will leverage our structural studies toward the design of small molecules to disrupt chromatin signaling pathways for basic research and therapeutic goals.<\/p>\n<\/div>\n<h3><span class=\"blue\">REPRESENTATIVE PUBLICATIONS<\/span><\/h3>\n<p><span class=\"normalSizeFont\" style=\"color: #666666;line-height: 1.43em;margin: 0px;padding: 0px;background-color: #ffffff\"><span class=\"discreet\" style=\"margin: 0px;padding: 0px\"><a class=\"external-link\" title=\"\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/myncbi\/browse\/collection\/50236942\/?sort=date&amp;direction=ascending\" target=\"_self\" rel=\"noopener noreferrer\"><img loading=\"lazy\" decoding=\"async\" class=\"image-inline\" style=\"color: #666666;line-height: 1.43em\" title=\"pubmed.png\" src=\"https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2019\/03\/pubmed.png\" alt=\"PubMed\" width=\"82\" height=\"33\" \/><\/a><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/myncbi\/browse\/collection\/50236942\/?sort=date&amp;direction=ascending\">(click<\/a><\/span><\/span><span class=\"DataField\"> <span class=\"discreet\">for Full Publication List)\u00a0<\/span><\/span><\/p>\n<p><span id=\"page18R_mcid34\" class=\"markedContent\"><span dir=\"ltr\" role=\"presentation\">Budziszewski GR, Zhao Y, Spangler CJ,<\/span> <span dir=\"ltr\" role=\"presentation\">Kedziora KM, Williams MR, Azzam DN,<\/span><br role=\"presentation\" \/><span dir=\"ltr\" role=\"presentation\">Skrajna A, Koyama Y, Cesmat AP, Simmons HC, Strauss JD, Kireev D,<\/span> <span dir=\"ltr\" role=\"presentation\">McGinty<\/span><br role=\"presentation\" \/><span dir=\"ltr\" role=\"presentation\">RK#<\/span><span dir=\"ltr\" role=\"presentation\">. Multivalent DNA and nucleosome acidic patch interactions specify VRK1<\/span><br role=\"presentation\" \/><span dir=\"ltr\" role=\"presentation\">mitotic localization and activity. (in review at Nucleic Acids Res)<\/span><\/span><span id=\"page18R_mcid35\" class=\"markedContent\"><br role=\"presentation\" \/><\/span><\/p>\n<p><span id=\"page18R_mcid35\" class=\"markedContent\"><span dir=\"ltr\" role=\"presentation\">Spa<\/span><span dir=\"ltr\" role=\"presentation\">ngler CJ, Yadav SP, Dongxu L, Geil CN, Smith CB, Wang GG*, Lee T<\/span><span dir=\"ltr\" role=\"presentation\">&#8211;<\/span><span dir=\"ltr\" role=\"presentation\">H*, and<\/span><br role=\"presentation\" \/><span dir=\"ltr\" role=\"presentation\">McGinty RK*. Dot1L activity in leukemia cells requires interaction with ubiquitylated<\/span><br role=\"presentation\" \/><span dir=\"ltr\" role=\"presentation\">H2B that promotes productive nucleosome binding. Cell Reports. 2022 (accepted)<\/span><\/span><span id=\"page18R_mcid36\" class=\"markedContent\"><br role=\"presentation\" \/><\/span><\/p>\n<p><span id=\"page18R_mcid36\" class=\"markedContent\"><span dir=\"ltr\" role=\"presentation\">Spangler CJ and<\/span> <span dir=\"ltr\" role=\"presentation\">Mc<\/span><span dir=\"ltr\" role=\"presentation\">Ginty RK#.<\/span> <span dir=\"ltr\" role=\"presentation\">Determination of histone methyltransferase<\/span><br role=\"presentation\" \/><span dir=\"ltr\" role=\"presentation\">structures in complex with the nucleosome by cryogenic electron microscopy.<\/span><br role=\"presentation\" \/><span dir=\"ltr\" role=\"presentation\">Methods Mol Biol. 2022 (accepted)<\/span><\/span><span id=\"page18R_mcid37\" class=\"markedContent\"><br role=\"presentation\" \/><\/span><\/p>\n<p><span id=\"page18R_mcid37\" class=\"markedContent\"><span dir=\"ltr\" role=\"presentation\">Waybright JM, Clinkscales SE, Barnash KD, Budziszewski GR, Rectenwald JM,<\/span><br role=\"presentation\" \/><span dir=\"ltr\" role=\"presentation\">Chiarella AM, Norr<\/span><span dir=\"ltr\" role=\"presentation\">is<\/span><span dir=\"ltr\" role=\"presentation\">&#8211;<\/span><span dir=\"ltr\" role=\"presentation\">Drouin JL, Cholensky SH, Pearce KH, Herring LE,<\/span> <span dir=\"ltr\" role=\"presentation\">McGinty<\/span><br role=\"presentation\" \/><span dir=\"ltr\" role=\"presentation\">RK<\/span><span dir=\"ltr\" role=\"presentation\">, Hathaway NA, and James LI. A peptidomimetic ligand targeting the<\/span><br role=\"presentation\" \/><span dir=\"ltr\" role=\"presentation\">chromodomain of MPP8 reveals MPP8\u2019s association with the HUSH complex. ACS<\/span><br role=\"presentation\" \/><span dir=\"ltr\" role=\"presentation\">Chem Biol. 2021 Sep 17;16(9):1721<\/span><span dir=\"ltr\" role=\"presentation\">&#8211;<\/span><span dir=\"ltr\" role=\"presentation\">1736.<\/span><\/span><span id=\"page18R_mcid38\" class=\"markedContent\"><br role=\"presentation\" \/><\/span><\/p>\n<p><span id=\"page18R_mcid38\" class=\"markedContent\"><span dir=\"ltr\" role=\"presentation\">McGinty RK*<\/span> <span dir=\"ltr\" role=\"presentation\">a<\/span><span dir=\"ltr\" role=\"presentation\">nd Tan S*. Principles of nucleosome recognition by chromatin<\/span><br role=\"presentation\" \/><span dir=\"ltr\" role=\"presentation\">factors and enzymes. Curr Opin Struct Biol. 2021 Jun 28;71:16<\/span><span dir=\"ltr\" role=\"presentation\">&#8211;<\/span><span dir=\"ltr\" role=\"presentation\">26.<\/span><\/span><span id=\"page18R_mcid39\" class=\"markedContent\"><br role=\"presentation\" \/><\/span><\/p>\n<p><span id=\"page18R_mcid39\" class=\"markedContent\"><span dir=\"ltr\" role=\"presentation\">Boyer<\/span> <span dir=\"ltr\" role=\"presentation\">JA,<\/span> <span dir=\"ltr\" role=\"presentation\">Spangler<\/span> <span dir=\"ltr\" role=\"presentation\">CJ,<\/span> <span dir=\"ltr\" role=\"presentation\">Strauss<\/span> <span dir=\"ltr\" role=\"presentation\">JD,<\/span> <span dir=\"ltr\" role=\"presentation\">Cesmat<\/span> <span dir=\"ltr\" role=\"presentation\">AP,<\/span> <span dir=\"ltr\" role=\"presentation\">Liu<\/span> <span dir=\"ltr\" role=\"presentation\">P,<\/span> <span dir=\"ltr\" role=\"presentation\">McGinty<\/span> <span dir=\"ltr\" role=\"presentation\">RK*<\/span><span dir=\"ltr\" role=\"presentation\">,<\/span> <span dir=\"ltr\" role=\"presentation\">Zhang<\/span> <span dir=\"ltr\" role=\"presentation\">Q*.<\/span><br role=\"presentation\" \/><span dir=\"ltr\" role=\"presentation\">Structural basis of nucleosome<\/span><span dir=\"ltr\" role=\"presentation\">&#8211;<\/span><span dir=\"ltr\" role=\"presentation\">dependent cGAS inhibit<\/span><span dir=\"ltr\" role=\"presentation\">ion. Science. 2020 Oct<\/span><br role=\"presentation\" \/><span dir=\"ltr\" role=\"presentation\">23;370(6515):450<\/span><span dir=\"ltr\" role=\"presentation\">&#8211;<\/span><span dir=\"ltr\" role=\"presentation\">454.<\/span><\/span><\/p>\n<p><span id=\"page22R_mcid0\" class=\"markedContent\"><span dir=\"ltr\" role=\"presentation\">Skrajna<\/span> <span dir=\"ltr\" role=\"presentation\">A,<\/span> <span dir=\"ltr\" role=\"presentation\">Goldfarb<\/span> <span dir=\"ltr\" role=\"presentation\">D,<\/span> <span dir=\"ltr\" role=\"presentation\">Kedziora<\/span> <span dir=\"ltr\" role=\"presentation\">KM,<\/span> <span dir=\"ltr\" role=\"presentation\">Cousins<\/span> <span dir=\"ltr\" role=\"presentation\">EM,<\/span> <span dir=\"ltr\" role=\"presentation\">Grant<\/span> <span dir=\"ltr\" role=\"presentation\">GD,<\/span> <span dir=\"ltr\" role=\"presentation\">Spangler<\/span> <span dir=\"ltr\" role=\"presentation\">CJ,<\/span> <span dir=\"ltr\" role=\"presentation\">Barbour<\/span><br role=\"presentation\" \/><span dir=\"ltr\" role=\"presentation\">EH, Yan X, Hathaway NA, Brown NG, Cook JG, Major MB,<\/span> <span dir=\"ltr\" role=\"presentation\">McGinty RK#<\/span><span dir=\"ltr\" role=\"presentation\">.<\/span><br role=\"presentation\" \/><span dir=\"ltr\" role=\"presentation\">Comprehensive<\/span> <span dir=\"ltr\" role=\"presentation\">nucleosome<\/span> <span dir=\"ltr\" role=\"presentation\">interactome<\/span> <span dir=\"ltr\" role=\"presentation\">screen<\/span> <span dir=\"ltr\" role=\"presentation\">establishes<\/span> <span dir=\"ltr\" role=\"presentation\">fundamental<\/span> <span dir=\"ltr\" role=\"presentation\">principles<\/span><br role=\"presentation\" \/><span dir=\"ltr\" role=\"presentation\">of nucleosome binding. Nucleic Acids Res. 2020 Sep 25;48(17):9415<\/span><span dir=\"ltr\" role=\"presentation\">&#8211;<\/span><span dir=\"ltr\" role=\"presentation\">9432.<\/span><\/span><span id=\"page22R_mcid1\" class=\"markedContent\"><br role=\"presentation\" \/><\/span><\/p>\n<p><span id=\"page22R_mcid1\" class=\"markedContent\"><span dir=\"ltr\" role=\"presentation\">Anderson<\/span> <span dir=\"ltr\" role=\"presentation\">CJ,<\/span> <span dir=\"ltr\" role=\"presentation\">Baird<\/span> <span dir=\"ltr\" role=\"presentation\">MR,<\/span> <span dir=\"ltr\" role=\"presentation\">Hsu<\/span> <span dir=\"ltr\" role=\"presentation\">A,<\/span> <span dir=\"ltr\" role=\"presentation\">Barbour<\/span> <span dir=\"ltr\" role=\"presentation\">EH,<\/span> <span dir=\"ltr\" role=\"presentation\">Koyama<\/span> <span dir=\"ltr\" role=\"presentation\">Y,<\/span> <span dir=\"ltr\" role=\"presentation\">Borgnia<\/span> <span dir=\"ltr\" role=\"presentation\">MJ,<\/span> <span dir=\"ltr\" role=\"presentation\">McGinty<\/span><br role=\"presentation\" \/><span dir=\"ltr\" role=\"presentation\">RK#<\/span><span dir=\"ltr\" role=\"presentation\">. Structural Basis for Recognition of Ubiquitylated Nucleosome by Dot1L<\/span><br role=\"presentation\" \/><span dir=\"ltr\" role=\"presentation\">Me<\/span><span dir=\"ltr\" role=\"presentation\">thyltransferase. Cell Reports. 2019 Feb 12;26(7):1681<\/span><span dir=\"ltr\" role=\"presentation\">&#8211;<\/span><span dir=\"ltr\" role=\"presentation\">1690.<\/span><\/span><span id=\"page22R_mcid2\" class=\"markedContent\"><br role=\"presentation\" \/><\/span><\/p>\n<p><span id=\"page22R_mcid2\" class=\"markedContent\"><span dir=\"ltr\" role=\"presentation\">Jeon J,<\/span> <span dir=\"ltr\" role=\"presentation\">McGinty RK<\/span><span dir=\"ltr\" role=\"presentation\">, Muir TW, Kim JA, Kim J. Crosstalk among Set1 complex<\/span><br role=\"presentation\" \/><span dir=\"ltr\" role=\"presentation\">subunits<\/span> <span dir=\"ltr\" role=\"presentation\">involved<\/span> <span dir=\"ltr\" role=\"presentation\">in<\/span> <span dir=\"ltr\" role=\"presentation\">H2B<\/span> <span dir=\"ltr\" role=\"presentation\">ubiquitylation<\/span><span dir=\"ltr\" role=\"presentation\">&#8211;<\/span><span dir=\"ltr\" role=\"presentation\">dependent<\/span> <span dir=\"ltr\" role=\"presentation\">H3K4<\/span> <span dir=\"ltr\" role=\"presentation\">methylation.<\/span> <span dir=\"ltr\" role=\"presentation\">Nucleic<\/span> <span dir=\"ltr\" role=\"presentation\">Acids<\/span><br role=\"presentation\" \/><span dir=\"ltr\" role=\"presentation\">Res. 2018 Nov<\/span> <span dir=\"ltr\" role=\"presentation\">30;46(21):11129<\/span><span dir=\"ltr\" role=\"presentation\">&#8211;<\/span><span dir=\"ltr\" role=\"presentation\">11143.<\/span><\/span><\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p><!-- description --> <\/p>\n<p class='lead'>Research: Mechanisms of epigenetic signaling<\/p>\n","protected":false},"featured_media":4813,"template":"","meta":{"_acf_changed":false,"layout":"","cellInformation":"","apiCallInformation":"","_links_to":"","_links_to_target":""},"class_list":["post-4812","directory","type-directory","status-publish","has-post-thumbnail","hentry","odd"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Robert McGinty | Biochemistry and Biophysics<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.med.unc.edu\/biochem\/directory\/mcginty\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" 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Robert"],"_upd_last_name":["McGinty"],"_upd_first_name":["Robert"],"_upd_sortorder_override":[],"_upd_sortorder":["1"],"_upd_gallery_summary":["<p class=\" \"><span style=\"color: #333333\"><span class=\"blue\"><em><strong><em>Associate Professor of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy\r\n<\/em><\/strong><\/em><\/span><\/span><span style=\"color: #333333\"><span style=\"color: #333333\"><span style=\"color: #333333;line-height: 1.43em\"><span class=\"blue\"><strong><em>\r\n<\/em>TRAINED MENTOR<\/strong><\/span><\/span><\/span><\/span><span style=\"color: #333333\"><span style=\"color: #333333\"><span style=\"color: #333333;line-height: 1.43em\"><span class=\"blue\"><span style=\"background-color: #4682b4;color: #ffffff\">\r\n<\/span><\/span><\/span><\/span><\/span><span style=\"color: #333333\"><span style=\"color: #333333\"><span style=\"color: #333333;line-height: 1.43em\"><span style=\"line-height: 1.43em;color: #333333\">Research: Mechanisms of epigenetic signaling\r\nCB#7363, 3210 Marsico Hall\r\ntel:(919) 843-4912 I<\/span><a class=\"email-link\" style=\"line-height: 1.43em\" title=\"\" href=\"mailto:rmcginty@email.unc.edu\" target=\"_self\"> Email<\/a>\r\n<a href=\"http:\/\/mcgintylab.web.unc.edu\/\">McGinty Lab website<\/a><\/span><\/span><\/span><\/p>"],"_upd_no_link":[],"_upd_degree1":[],"_upd_degree2":[],"_upd_email":[[{"email_text":"rmcginty@email.unc.edu"}]],"_upd_phone":[[{"phone_text":"919-843-4912","phone_type":"Office Phone"}]],"_upd_address":[[{"address":{"address-1":"125 Mason Farm Road","address-2":"3210 Marsico Hall, McGinty lab","campus-box":"CB# 7363","city":"Chapel Hill","state":"NC","zip":"27599-7363"}}]],"_links":{"self":[{"href":"https:\/\/www.med.unc.edu\/biochem\/wp-json\/wp\/v2\/directory\/4812","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.med.unc.edu\/biochem\/wp-json\/wp\/v2\/directory"}],"about":[{"href":"https:\/\/www.med.unc.edu\/biochem\/wp-json\/wp\/v2\/types\/directory"}],"version-history":[{"count":1,"href":"https:\/\/www.med.unc.edu\/biochem\/wp-json\/wp\/v2\/directory\/4812\/revisions"}],"predecessor-version":[{"id":31966,"href":"https:\/\/www.med.unc.edu\/biochem\/wp-json\/wp\/v2\/directory\/4812\/revisions\/31966"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.med.unc.edu\/biochem\/wp-json\/wp\/v2\/media\/4813"}],"wp:attachment":[{"href":"https:\/\/www.med.unc.edu\/biochem\/wp-json\/wp\/v2\/media?parent=4812"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}